A road map for identifying autism spectrum disorder: Recognizing and evaluating characteristics that should raise red or “pink” flags to guide accurate differential diagnosis

Duvall, Susanne W.; Armstrong, Kira; Shahabuddin, Ambreen; Grantz, Caroline J.; Fein, Deborah; Lord, Catherine

doi:10.1080/13854046.2021.1921276

Cited by 17 publications

(4 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deficits in social communication and interaction are the most commonly reported red flags and significant core symptoms of ASD ( 1 ). These core impairments not only disrupt children's ability to develop and maintain social relationships but also impact their long-term outcomes ( 3 , 4 ). Moreover, the difficulties and challenges that accompany the child's social impairment can lead to considerable parenting stress and caregiving burden, which further disrupts parental psychological wellbeing and quality of life ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Online-Delivered Project ImPACT for Children With ASD and Their Parents: A Pilot Study During the COVID-19 Pandemic

Ren

Shen

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

ObjectiveDuring the COVID-19 pandemic, face-to-face intervention services for families of children with autism spectrum disorder (ASD) were limited. This study aimed to evaluate the effectiveness of an 8-week, online-delivered Project ImPACT program for children with ASD and their parents in China during the COVID-19 pandemic.MethodsA pilot non-randomized study with a waitlist control group was conducted in 68 children with ASD and their parents in the Department of Developmental and Behavioral Pediatrics between April 15, 2020 and March 19, 2021. Participants were allocated to either the intervention (IG) or the waitlist group (WLG) according to their order of recruitment. Parents in the IG immediately received 8 weeks of the online-delivered Project ImPACT program, and the WLG received the same program with a delay when the IG had completed all sessions. Participants in both groups received treatment as usual during the research period.ResultsThe online-delivered Project ImPACT program significantly improved the parent-reported social communication skills of children with ASD. Furthermore, parent's involvement in the training program produced a collateral reduction in parenting stress and an increase in perceived competence in the parental role. Parents rated the program acceptable in terms of curriculum schedule, session content, homework assignments, and therapist feedback.ConclusionsThe 8-week, online-delivered Project ImPACT program is a feasible and effective social skill training program for families of children with ASD in China during the COVID-19 pandemic. Due to the methodological limitations, randomized controlled studies with larger sample sizes are suggested to provide more solid evidence.

show abstract

Section: Introductionmentioning

confidence: 99%

Effectiveness of Online-Delivered Project ImPACT for Children With ASD and Their Parents: A Pilot Study During the COVID-19 Pandemic

Ren

Shen

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…For earlier diagnosis developmental regression may be used or by observation of clinical "red flags". 70 Earlier the detection earlier can be the preventive interventions.…”

Section: Intervention In First Three Years Of Lifementioning

confidence: 99%

Autism Spectrum Disorders-A Review on The Preventive Aspects

Barik

Patnaik

Pattanaik

2023

Natl J Community Med

View full text Add to dashboard Cite

Autism Spectrum disorder (ASD) is a neurodevelopmental disorder presenting with defects in social communication skills and repetitive sensory motor behaviour. There has been increasing concern regarding this disorder due to its increase in incidence and prevalence in recent years. Since it stays for lifelong and has no specific pharmacological treatment, many studies are being conducted to find ways of preventing this disorder. Better understanding of the causative factors will lead to better development of prevention strategies. This review aims at highlighting the methods of prevention of ASD which are mostly focussed on the environmental factors causing ASD as well as the ongoing researches on development of drugs and genetic modification using animal models. Some studies have shown preventive effects of factors such as nutrition supplements such as Vitamin D and folate, breastfeeding and avoiding exposure to harmful chemicals and drugs. The aim is to prevent the occurrence of the disorder and preventing the severity of symptoms wherever possible. Still more studies are needed to establish the exact association between the possible causative factors and ASD so that clinical trials can be done to establish the preventive effects in future.

show abstract

“…Their rs-fMRI images were acquired on a clinically conventional 3.0 Tesla GE Signa scanner. The imaging sequence parameters were as follows: scanning time = 10 min, TR/TE = 2000/30 ms, 40 slices, time point T = 300, flip angle = 90°, and voxel size = 3.438 × 3.438 × 3.0 mm 3 .…”

Section: Data Acquisition and Preprocessingmentioning

confidence: 99%

“…The prevalence of ASD was reported to be 0.72% in the two decades between 2000 and 2020 [2]. Although there is a growing concern about ASD, the current diagnosis of ASD is mainly based on patient behavior and simple observation of symptoms, which easily leads to a high misdiagnosis rate and, thus, delayed treatment [3]. Therefore, it is important to explore a reliable and automatic strategy to assist in the diagnosis of ASD at an early stage [4].…”

Section: Introductionmentioning

confidence: 99%

Learning to Fuse Multiple Brain Functional Networks for Automated Autism Identification

Zhang

Qiao

et al. 2023

Biology

View full text Add to dashboard Cite

Functional connectivity network (FCN) has become a popular tool to identify potential biomarkers for brain dysfunction, such as autism spectrum disorder (ASD). Due to its importance, researchers have proposed many methods to estimate FCNs from resting-state functional MRI (rs-fMRI) data. However, the existing FCN estimation methods usually only capture a single relationship between brain regions of interest (ROIs), e.g., linear correlation, nonlinear correlation, or higher-order correlation, thus failing to model the complex interaction among ROIs in the brain. Additionally, such traditional methods estimate FCNs in an unsupervised way, and the estimation process is independent of the downstream tasks, which makes it difficult to guarantee the optimal performance for ASD identification. To address these issues, in this paper, we propose a multi-FCN fusion framework for rs-fMRI-based ASD classification. Specifically, for each subject, we first estimate multiple FCNs using different methods to encode rich interactions among ROIs from different perspectives. Then, we use the label information (ASD vs. healthy control (HC)) to learn a set of fusion weights for measuring the importance/discrimination of those estimated FCNs. Finally, we apply the adaptively weighted fused FCN on the ABIDE dataset to identify subjects with ASD from HCs. The proposed FCN fusion framework is straightforward to implement and can significantly improve diagnostic accuracy compared to traditional and state-of-the-art methods.

show abstract

A road map for identifying autism spectrum disorder: Recognizing and evaluating characteristics that should raise red or “pink” flags to guide accurate differential diagnosis

Cited by 17 publications

References 123 publications

Effectiveness of Online-Delivered Project ImPACT for Children With ASD and Their Parents: A Pilot Study During the COVID-19 Pandemic

Effectiveness of Online-Delivered Project ImPACT for Children With ASD and Their Parents: A Pilot Study During the COVID-19 Pandemic

Autism Spectrum Disorders-A Review on The Preventive Aspects

Learning to Fuse Multiple Brain Functional Networks for Automated Autism Identification

Contact Info

Product

Resources

About