A risk model of prenatal screening markers in first trimester for predicting hypertensive disorders of pregnancy

Chen, Yiming; Xie, Zhen; Wang, Xue; Xiao, Qingxin; Xiao, Lü; Lu, Sha; Shi, Yezhen; Lv, Shaolei

doi:10.1007/s13167-020-00212-3

Cited by 16 publications

(17 citation statements)

References 42 publications

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“…Moreover, all MoM values used in this study were corrected by gestational age and maternal weight. Consequently, maternal weight had little effect on predictive ability when using AFP and free-β hCG [ 24 ]. The further studies should seek to weight-match control and hypertensive subjects.…”

Section: Discussionmentioning

confidence: 99%

“…In unaffected pregnancies, aneuploidy screening markers change with gestational age [ 24 ]. Therefore, levels of DD, AFP and free β-hCG were expressed using MoM values.…”

Section: Methodsmentioning

confidence: 99%

“…MoM values are calculated by dividing the original concentrations of DD, AFP and free β-hCG by the population median at the gestational age at which the marker was tested. MoM adjustments for covariables such as gestational age and maternal weight were also performed according to published data [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…Let χ be the vector of three-dimension normal distribution: χ = ( χ 1 , χ 2 , χ 3 ) T where, |Σ| is the determinant of the covariance matrix of χ , Σ −1 represents the inverse matrix of the covariance matrix of χ , and is the average. χ denotes the logarithm of the DD MoM, AFP MoM, and free β-hCG MoM value [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

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Second trimester maternal serum D-dimer combined with alpha-fetoprotein and free β-subunit of human chorionic gonadotropin predict hypertensive disorders of pregnancy: a systematic review and retrospective case–control study

Chen

Chu

et al. 2021

J Transl Med

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Background This study investigated whether maternal serum D-dimer (DD) alone or DD combined with alpha-fetoprotein (AFP) and free β-subunit of human chorionic gonadotropin (free β-hCG) in the second trimester could be used to predict hypertensive disorders of pregnancy (HDP). Materials and methods In this retrospective case–control study, the data of gravidas patients who delivered at hospital were divided into the following groups: control (n = 136), gestational hypertension (GH, n = 126), preeclampsia (PE, n = 53), and severe preeclampsia (SPE, n = 41). Receiver operator characteristic (ROC) curves were used to evaluate the diagnostic value of maternal serum DD, AFP, and free β-hCG levels for HDP. Results DD levels of the GH, PE, and SPE groups were significantly higher than that of the control group (P < 0.001). The order of effectiveness for models predicting HDP was as follows: DD + AFP + free β-hCG > DD > DD + AFP > DD + free β-hCG > AFP + free β-hCG > AFP > free β-hCG. For predicting different types of HDP, DD alone had the best diagnostic value for SPE, followed by PE and GH. DD alone had a sensitivity of 100% with a 0% false negative rate and had the highest positive likelihood ratio (+ LR) for SPE. DD alone in combination with AFP alone, free β-hCG alone and AFP + free β-hCG could reduce false positive rate and improve + LR. Conclusion DD is possible the best individual predictive marker for predicting HDP. Levels of DD alone in the second trimester were positively correlated with the progression of elevated blood pressure in the third trimester, demonstrating the predicting the occurrence of HDP. The risk calculation model constructed with DD + free β-hCG + AFP had the greatest diagnostic value for SPE.

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Section: Discussionmentioning

confidence: 99%

“…In unaffected pregnancies, aneuploidy screening markers change with gestational age [ 24 ]. Therefore, levels of DD, AFP and free β-hCG were expressed using MoM values.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Second trimester maternal serum D-dimer combined with alpha-fetoprotein and free β-subunit of human chorionic gonadotropin predict hypertensive disorders of pregnancy: a systematic review and retrospective case–control study

Chen

Chu

et al. 2021

J Transl Med

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“…risk maternal age = 0.0000697 + exp −18.4367+0.286×(maternal age−0.5) The likelihood ratio was calculated as follows [16,18]:…”

Section: Methods For Establishing Different Risk Prediction Modelsmentioning

confidence: 99%

A Risk Model for Predicting Fetuses with Trisomy 21 Using Alpha-Fetoprotein Variants L2 Combined with Maternal Serum Biomarkers in Early Pregnancy

Chen

Ning

et al. 2021

Reprod. Sci.

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To establish a risk prediction model and the clinical value of trisomy 21 using alpha-fetoprotein variants L2 (AFP-L2) combined with maternal serum biomarkers and nuchal translucency (NT) thickness in early pregnancy. A retrospective case–control study was conducted. The subjects were divided into the case group (n = 40) or the control group (n = 40). An enzyme-linked immunosorbent assay was used to measure the maternal serum AFP-L2 level in both groups. The AFP-L2 single-index or multi-index combined risk model was used to predict the efficiency of trisomy 21. The best cut-off value and area under the curve (AUC) were determined to evaluate the predictive efficacy of different risk models constructed by AFP-L2. The maternal serum AFP-L2 level in the case group was 1.59 (0.61–3.61) Multiple of medium (MoM), which was higher than 1.00 (0.39–2.12) MoM in the control group (P < 0.001). The free beta-human chorionic gonadotropin (free β-hCG) level and NT in the case group were significantly higher than those in the control group (P < 0.001). The pregnancy-associated plasma protein A (PAPP-A) level in the case group was lower than that in the control group (P < 0.001). The AUC of AFP-L2 in predicting trisomy 21 was 0.797. After considering the maternal serum AFP-L2 level, the AUC, detection rate (DR), positive predictive value (PPV), negative predictive value (NPV), falsepositive rate (FPR), false negative rate (FNR), positive likelihood ratio (+LR), and negative likelihood ratio (-LR) were significantly improved. In this study, PAPP-A + free β-hCG + NT + AFP-L2 and PAPP-A + free β-hCG + AFP-L2 increased the integrated discrimination improvement (IDI) and net classification improvement (NRI) of predicting fetuses with trisomy 21 (1.10% and 5.27%; 11.07% and 2.78%) (1.10% and 5.27%; 11.07% and 2.78%), respectively, after considering the maternal serum AFP-L2 level. The maternal serum AFP-L2 level in early pregnancy had high sensitivity and specificity, and it was a good biomarker to predict fetuses with trisomy 21.

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Physiology of Pregnancy‐Related Acute Kidney Injury

Moronge

Sullivan

Faulkner

2023

Comprehensive Physiology

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A risk model of prenatal screening markers in first trimester for predicting hypertensive disorders of pregnancy

Cited by 16 publications

References 42 publications

Second trimester maternal serum D-dimer combined with alpha-fetoprotein and free β-subunit of human chorionic gonadotropin predict hypertensive disorders of pregnancy: a systematic review and retrospective case–control study

Second trimester maternal serum D-dimer combined with alpha-fetoprotein and free β-subunit of human chorionic gonadotropin predict hypertensive disorders of pregnancy: a systematic review and retrospective case–control study

A Risk Model for Predicting Fetuses with Trisomy 21 Using Alpha-Fetoprotein Variants L2 Combined with Maternal Serum Biomarkers in Early Pregnancy

Physiology of Pregnancy‐Related Acute Kidney Injury

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