1996
DOI: 10.2165/00002018-199615040-00005
|View full text |Cite
|
Sign up to set email alerts
|

A Risk-Benefit Assessment of Naltrexone in the Treatment of Alcohol Dependence

Abstract: There is a great deal of interest in the use of naltrexone as a treatment for alcohol (ethanol) dependence since there is a rapidly expanding body of evidence to support its efficacy and tolerability in this indication. Naltrexone, a long-acting, nonselective opioid receptor antagonist has been shown to reduce alcohol intake when combined with behavioural treatment. Naltrexone may prevent the return to clinically significant drinking by blocking the pleasurable effects or "high' associated with alcohol drinkin… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
31
0

Year Published

1997
1997
2022
2022

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 48 publications
(31 citation statements)
references
References 27 publications
0
31
0
Order By: Relevance
“…Opiate antagonists can reduce human ethanol consumption ) and may be efficacious in the treatment of alcoholism (Berg et al 1996;Kranzler et al 1997Kranzler et al , 1998bMason et al 1999). The mechanisms for these effects are uncertain, however.…”
Section: Introductionmentioning
confidence: 99%
“…Opiate antagonists can reduce human ethanol consumption ) and may be efficacious in the treatment of alcoholism (Berg et al 1996;Kranzler et al 1997Kranzler et al , 1998bMason et al 1999). The mechanisms for these effects are uncertain, however.…”
Section: Introductionmentioning
confidence: 99%
“…One possible candidate is naltrexone, a pharmacotherapy that has demonstrated safety and efficacy as an adjunct in the treatment of alcohol dependence (O'Malley et al 1992;Volpicelli et al 1992;Berg et al 1996). Although the mechanisms by which naltrexone works are not well understood, naltrexone's effectiveness has been attributed to its ability to reduce activation of the mesolimbic dopamine system through the antagonism of mu-opiate receptors.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, naltrexone has been reported to cause reversible, mild-to-moderate liver toxicity in some patients when administered at doses of 150 mg/d or higher. 17,18 Although liver enzyme elevation does not appear to be an issue at the dose approved for treatment of alcohol dependence, naltrexone, nevertheless, has received a black box warning from the FDA due to the risk of hepatic toxicity (Physicians Desk Reference 19 ).…”
mentioning
confidence: 99%