A Rice Bran Oil Diet Improves Lipid Abnormalities and Suppress Hyperinsulinemic Responses in Rats with Streptozotocin/Nicotinamide-Induced Type 2 Diabetes

Chou, Tsui-Wei; Ma, Chien-Ya; Cheng, Hercy N.H.; Chen, Ya-Yen; Lai, Ming-Hoang

doi:10.3164/jcbn.08-257

Cited by 71 publications

(51 citation statements)

References 48 publications

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“…This finding is in agreement with previous studies that there are no positive reduction of plasma and hepatic cholesterol concentrations [21]- [24]. Chou et al [25] observed that the rice bran oil group (0.9 g γ-tocotrienol and 5.25 g γ-oryzanol/kg diet) did not lower plasma total cholesterol, triglyceride, and LDL cholesterol and hepatic triglyceride levels compared with the control group.…”

Section: Discussionsupporting

confidence: 82%

Effects of Tocols Rich Fraction Isolated from Rice Bran Oil Deodorizer Distillate on Plasma and Hepatic Lipid Concentrations in Rats

Gomes¹,

Gu²,

Brownmiller³

et al. 2015

JBM

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A great deal of attention has been focused on the potential health benefits of using rice bran oil because it is a rich source of bioactive compounds. Rice bran oil deodorizer distillate (RBODD) is a byproduct obtained from distillation of rice bran oil. Elevated plasma cholesterol level is one of the major risk factors for coronary heart disease. The objective of this study was to investigate the effects of tocols (tocopherols + tocotrienols) rich fraction isolated from RBODD on plasma and liver lipid concentrations in rats. Male Sprague Dawley rats (6 weeks of age) were randomly assigned into three groups: normal fat control (NFC), high fat control (HFC) and high fat diet plus tocols rich fraction (RBODD). RBODD was administered daily for 3 weeks by oral gavage using 5% of Tween-80 as a vehicle. The rats in the control groups received 5% of Tween-80 alone in the same manner. Blood samples and livers were collected at the end of the feeding period. RBODD group had significantly lower plasma triglyceride levels compared to the HFC group (p < 0.05). However, no significant changes for plasma total and lipoprotein cholesterol levels were found in RBODD compared with HFC. Compared to the rat fed HFC, hepatic free fatty acids were significantly reduced in the rats with the RBODD treatment (p < 0.05). The results suggest that the tocols rich fraction isolated from RBODD is associated with decreased plasma triglyceride and hepatic free fatty acids concentrations. Further study is needed to investigate the mechanism and optimal dose by which isomers of tocols lower triglyceride concentrations.

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Section: Discussionsupporting

confidence: 82%

Effects of Tocols Rich Fraction Isolated from Rice Bran Oil Deodorizer Distillate on Plasma and Hepatic Lipid Concentrations in Rats

Gomes¹,

Gu²,

Brownmiller³

et al. 2015

JBM

View full text Add to dashboard Cite

show abstract

“…1,2,[4][5][6][7][8][9]28,[44][45][46][47] In this study we found the effects of whole dietary rice bran intake on the mucosal immune system to be the induction of IgA (Fig. 1) and the enhancement of the innate immune response (Table 3).…”

Section: Discussionmentioning

confidence: 73%

“…The removal of the bran results in the loss of many prebiotic components and beneficial nutrients, including various polyphenols, essential fatty acids, and numerous antioxidants. [1][2][3] Dietary rice bran intake has been shown to aid in protection against gastrointestinal cancers, 1,4,5 improve lipid metabolism in diabetic rats, 6 and significantly lower cholesterol levels in humans 7,8 and hamsters. 9 Also, rice branderived prebiotics suppress inflammatory bowel disease 10,11 by decreasing ulceration and inducing beneficial effects on the intestinal mucosa through the production of antiinflammatory cytokines.…”

Section: Introduction Rmentioning

confidence: 99%

Consumption of Rice Bran Increases Mucosal Immunoglobulin A Concentrations and Numbers of IntestinalLactobacillusspp.

Henderson

Kumar

Barnett

et al. 2012

Journal of Medicinal Food

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Gut-associated lymphoid tissue maintains mucosal homeostasis by combating pathogens and inducing a state of hyporesponsiveness to food antigens and commensal bacteria. Dietary modulation of the intestinal immune environment represents a novel approach for enhancing protective responses against pathogens and inflammatory diseases. Dietary rice bran consists of bioactive components with disease-fighting properties. Therefore, we conducted a study to determine the effects of whole dietary rice bran intake on mucosal immune responses and beneficial gut microbes. Mice were fed a 10% rice bran diet for 28 days. Serum and fecal samples were collected throughout the study to assess total immunoglobulin A (IgA) concentrations. Tissue samples were collected for cellular immune phenotype analysis, and concentrations of native gut Lactobacillus spp. were enumerated in the fecal samples. We found that dietary rice bran induced an increase in total IgA locally and systemically. In addition, B lymphocytes in the Peyer's patches of mice fed rice bran displayed increased surface IgA expression compared with lymphocytes from control mice. Antigen-presenting cells were also influenced by rice bran, with a significant increase in myeloid dendritic cells residing in the lamina propria and mesenteric lymph nodes. Increased colonization of native Lactobacillus was observed in rice bran-fed mice compared with control mice. These findings suggest that rice bran-induced microbial changes may contribute to enhanced mucosal IgA responses, and we conclude that increased rice bran consumption represents a promising dietary intervention to modulate mucosal immunity for protection against enteric infections and induction of beneficial gut bacteria.

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“…In humans, many studies have been reported on its potential implications as a UV-A filter in sunscreen cosmetics [14] and as a treatment for type 2 diabetes mellitus [12] and allergic reactions [37]. These data suggest that gamma-oryzanol, especially because of its antioxidant and scavenging activities, can be useful as an antioxidant and lipid peroxidation inhibitor (i.e., membrane stabilizing) during cryopreservation.…”

mentioning

confidence: 87%

Effect of Gamma-Oryzanol-Enriched Rice Bran Oil on Quality of Cryopreserved Boar Semen

Kaeoket

Donto

Nualnoy

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. The aim of this study was to determine the effect of gamma-oryzanol-enriched -rice bran oil on the quality of cryopreserved boar semen. Ten boars provided semen of proven motility and morphology for this study. The semen was divided into three portions in which lactose-egg yolk (LEY) extender used to resuspend the centrifuged sperm pellet was supplemented with 2 types of rice bran oils, at a gamma-oryzanol concentration of 0 mg/ml of lactose egg yolk (LEY) freezing extender (group A, control), 0.1 mg/ml(0.16 mMol) of freezing extender (group B) and 0.1 mg/ml of freezing extender (group C). Semen suspensions were loaded in medium straws (0.5 ml) and placed in a controlled-rate freezer. After cryopreservation, frozen semen samples were thawed and investigated for progressive motility, viability and acrosomal integrity. There was a significantly higher percentage of progressive motility (34 versus 47.0 and 48.5, P<0.001), viability (35.5 versus 48.1 and 50.1, P<0.001) and acrosomal integrity (39.8 versus 50.8 and 54.9, P<0.001) in the gamma-oryzanolenriched rice bran oil-supplemented groups (groups B, C) than in the control group (group C), respectively. In conclusion, addition of gamma-oryzanol-enriched rice bran oil to LEY freezing extender is appropriated for improving the quality of frozen-thawed boar semen. Cryopreservation of boar spermatozoa offers an effective way to maintain their valuable genetic material and transport it between countries, thereby minimizing boar transportation. It has been demonstrated that certain processes in cryopreservation including elimination of seminal plasma by centrifugation and reduction in the temperature result in cold shock, owing to a decrease in quantity of antioxidants and an increase in reactive oxygen species (ROS) contents in the semen [6,8,43]. The ROS can lead to oxidative stress and lipid peroxidation of the sperm plasma membrane, which have detrimental effects on spermatozoa during cryopreservation, for instance, reduction in progressive motility, acrosomal integrity, sperm-oocyte fusion and fertilizing potential [1-3, 17, 41, 53].During the past decade, several studies have focused on supplementation of freezing extender for frozen boar semen with a variety of antioxidants (e.g., vitamin E, vitamin C, L-cysteine, glutathione, taurine, pyruvate, SOD, catalase) in an attempt to minimize the detrimental effects of ROS, which occur during the freezing process [7,10,16,23,26,38,39].Gamma-oryzanol, a phytosteryl ferulate mixture extracted from rice bran oil, has received a great deal of attention, because of its various significant health-promoting functions such as antioxidant activity, inhibition of lipoperoxidation by its scavenging activity [4], reduction in LDL cholesterol and induction of HDL cholesterol [40,41,48] and inhibition of platelet aggregation [13]. In humans, many studies have been reported on its potential implications as a UV-A filter in sunscreen cosmetics [14] and as a treatment for type 2 diabetes mellitus [12] and allergic reactions [3...

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A Rice Bran Oil Diet Improves Lipid Abnormalities and Suppress Hyperinsulinemic Responses in Rats with Streptozotocin/Nicotinamide-Induced Type 2 Diabetes

Cited by 71 publications

References 48 publications

Effects of Tocols Rich Fraction Isolated from Rice Bran Oil Deodorizer Distillate on Plasma and Hepatic Lipid Concentrations in Rats

Effects of Tocols Rich Fraction Isolated from Rice Bran Oil Deodorizer Distillate on Plasma and Hepatic Lipid Concentrations in Rats

Consumption of Rice Bran Increases Mucosal Immunoglobulin A Concentrations and Numbers of IntestinalLactobacillusspp.

Effect of Gamma-Oryzanol-Enriched Rice Bran Oil on Quality of Cryopreserved Boar Semen

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