A rhodamine-based single-molecular theranostic agent for multiple-functionality tumor therapy

Theranostics with photodynamic therapy for personalized medicine: to see and to treat

“…The compounds showed low systemic toxicity, in combination with a good bioavailability and significant suppression of tumor growth (intra-tumoral: up to 74.6%; intravenous: up to 48.5%). Upon irradiation of the tumor tissue (660 nm, 200 mW/cm², 15 min) this suppression effect on tumor growth could be increased significantly (intra-tumoral: up to 93.9%; intravenous: up to 90.2%) 83 .…”

“… Theranostic agents containing rhodamine, and the photosensitizer protoporphyrin IX for a combined approach of NIR-imaging and PDT 83 - 85 . …”

Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

“…63). 398 They conjugated nitrogen mustard derivatives with rhodamine dyes, which not only red-shifted the absorption and emission wavelengths of RAC to the near-infrared region but also made the entire molecule chemotherapeutically active. The significant decrease in the absorption peak of DPBF at 410 nm after 660 nm light exposure in ethanol solution confirmed the ability of RAC to produce 1 O 2 .…”