A rheumatoid arthritis patient with chronic recurrent annular neutrophilic dermatosis: Are we dealing with a new type of rheumatoid arthritis-associated dermatosis?

Değirmentepe, Ece Nur; Kocatürk, Emek; Yüksel, Tülin; Akbaş, Pırıl Etikan; Topal, İlteriş Oğuz; Büyükbabanı, Nesimi

doi:10.1016/j.dsi.2016.06.002

Cited by 2 publications

(3 citation statements)

References 7 publications

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“… 6 , 16 The dermatological lesion in RND can be either palpable purpura or plaque or nodule in the extensor surfaces of extremities, and joints are favored locations as in our presenting patient who showed nodulopapular lesions in the thighs and the lower part of the abdomen. 16 , 17 The RND skin biopsy under the microscope will show a neutrophilic infiltrate, 18 and this is the same histopathological feature of the skin biopsy revealed in our patient, as it showed mixed inflammatory infiltrate with no evidence of vasculitis.…”

Section: Discussionsupporting

confidence: 82%

Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report

Rodwan

Mohammed

Essa

et al. 2022

Clinical Case Reports

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Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by symmetric and destructive polyarthritis with a broad‐spectrum clinical manifestation of various organs. RND is an unusual distinctive manifestation of RA and typically develops in severe RA. This report aims to present an unusual and a rare neutrophilic skin condition, in a seronegative RA Sudanese patient. A 51‐year‐old woman was diagnosed with RA three years ago and a history of bilateral polyarthritis, presented with a skin rash involving her extremities and abdomen. Clinical examination of her skin revealed the presence of maculopapular lesions affecting the extensor surfaces of the lower extremities and the lower part of the abdomen with hyperpigmentation. Hand X‐ray demonstrated periarticular osteopenia, and laboratory and immunological studies that include C‐reactive protein, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anticitrullinated peptide antibodies (ACPAs), and antinuclear factor in addition to skin biopsy were all suggested a diagnosis of neutrophilic dermatosis. The patient received steroids for the skin lesion still no significant improvement was seen, and then, cyclosporin 100 mg was administrated twice/ day with close monitoring, and two weeks later marked improvement was shown.

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Section: Discussionsupporting

confidence: 82%

Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report

Rodwan

Mohammed

Essa

et al. 2022

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…Review of clinical data revealed that this patient had DM triggered by adalimumab which was administered for rheumatoid arthritis, a clinical setting previously reported 16,17 . A diagnosis of rheumatoid neutrophilic dermatitis was excluded based on the absence of annular lesions and leukocytoclasia on biopsy 18 . While the presence of neutrophils is not classically described in DM, further studies are required to determine whether a neutrophilic infiltrate correlates with drug‐induced DM.…”

Section: Discussionmentioning

confidence: 81%

“…16,17 A diagnosis of rheumatoid neutrophilic dermatitis was excluded based on the absence of annular lesions and leukocytoclasia on biopsy. 18 While the presence of neutrophils is not classically described in DM, further studies are required to determine whether a neutrophilic infiltrate correlates with drug-induced DM.…”

Section: Discussionmentioning

confidence: 99%

Do histopathological features correlate with systemic manifestations in dermatomyositis? Analysis of 42 skin biopsy specimens from 22 patients

et al. 2022

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Background Understanding whether specific histopathologic features on skin biopsy are predictive of systemic associations in dermatomyositis (DM) would be useful to guide clinical screening. Methods Through retrospective medical record search, clinical and laboratory findings of patients with DM were documented. Existing skin biopsy slides were re‐reviewed blindly. Results Of all biopsy specimens (n = 42), the most frequent histopathological finding was vacuolar interface dermatitis (95%). Other features included perivascular lymphocytic infiltrate (71%), increased dermal mucin (40%), vessel wall thickening (12%), follicular plugging (9.5%), and dermal sclerosis (7%). Neutrophilic infiltrate was observed in three biopsies from a patient with adalimumab‐associated DM. Vasculitis was not observed. There was no statistically significant difference in the presence of any histopathological feature and that of various systemic manifestations (i.e., myopathy, interstitial lung disease [ILD] and malignancy). However, we observed that dense lichenoid infiltrate rather than pauci‐inflammatory changes correlated with severe itching (p < 0.001). Patients with MDA‐5 antibodies were significantly more likely to have vasculopathy than those without (p = 0.029*). Conclusions No dermatopathologic feature was reliably predictive of myopathy, ILD, or malignancy. This finding implies that, regardless of histopathologic findings, patients should be screened for associated conditions as clinically indicated.

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A rheumatoid arthritis patient with chronic recurrent annular neutrophilic dermatosis: Are we dealing with a new type of rheumatoid arthritis-associated dermatosis?

Cited by 2 publications

References 7 publications

Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report

Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report

Do histopathological features correlate with systemic manifestations in dermatomyositis? Analysis of 42 skin biopsy specimens from 22 patients

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