A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals

Li, Zheng; Jiang, Hong; Xu, Changmou; Gu, Liwei

doi:10.1016/j.foodhyd.2014.05.010

Cited by 305 publications

(179 citation statements)

References 185 publications

Supporting

Mentioning

168

Contrasting

Unclassified

Order By: Relevance

“…Interaction of phenolic phytochemicals with hydrophobic sites of nanoparticles through hydrogen bonds and hydrophobic forces is well established. Sufficient surface charges and suitable hydration property keep phenolic phytochemical encapsulated nanoparticles stable in aqueous system, which enhances the water solubility of phenolic phytochemicals (Li et al 2015). Significant decrease in zeta potential value of CS-TPP NPs upon FA encapsulation from approximately ?44 FA ferulic acid, NPs nanoparticles, EE encapsulation efficiency, LC loading capacity, FA/CS-TPP ferulic acid-loaded chitosan-tripolyphosphate pentasodium, Avg average, Dia diameter to ?22 meV was observed.…”

Section: Resultsmentioning

confidence: 99%

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

et al. 2015

View full text Add to dashboard Cite

Ferulic acid (FA) is a widely distributed hydroxycinnamic acid found in various cereals and fruits exhibiting potent antioxidant and anticancer activities. However, due to low solubility and permeability, its availability to biological systems is limited. Non-toxic chitosan-tripolyphosphate pentasodium (CS-TPP) nanoparticles (NPs) are used to load sparingly soluble molecules and drugs, increasing their bioavailability. In the present work, we have encapsulated FA into the CS-TPP NPs to increase its potential as a therapeutic agent. Different concentrations of FA were tested to obtain optimum sized FA-loaded CS-TPP nanoparticles (FA/CS-TPP NPs) by ionic gelation method. Nanoparticles were characterized by scanning electron microscopy, Fourier transformation infrared spectroscopy (FTIR), thermogravimetric analyses and evaluated for their anticancer activity against ME-180 human cervical cancer cell lines. The FTIR spectra confirmed the encapsulation of FA and thermal analysis depicted its degradation profile. A concentration-dependent relationship between FA encapsulation efficiency and FA/ CS-TPP NPs diameter was observed. Smooth and spherical FA-loaded cytocompatible nanoparticles with an average diameter of 125 nm were obtained at 40 lM FA conc. The cytotoxicity of 40 lM FA/CS-TPP NPs against ME-180 cervical cancer cell lines was found to be higher as compared to 40 lM native FA. Apoptotic morphological changes as cytoplasmic remnants and damaged wrinkled cells in ME-180 cells were visualized using scanning electron microscopic and fluorescent microscopic techniques. Data concluded that chitosan enveloped FA nanoparticles could be exploited as an excellent therapeutic drug against cancer cells proliferation.

show abstract

Section: Resultsmentioning

confidence: 99%

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies have also strongly shown that consumption of vegetables positively correlated to prevention of degenerative diseases (Li et al 2015), while studies have established high correlation between antioxidant activity and phytochemicals of vegetables (Olajire and Azeez 2011). However, the composition and concentration of phytochemicals in vegetables are influenced by many factors, such as soil condition (chemical form, bioavailability and mobility), photosynthesis pigment contents and climatic conditions (Chandra et al 2014;Leonov et al 2015;Li et al 2015;Schlich and Hund-Rinke 2015). A novel way to improve the quantity and quality of phytochemicals in vegetables is through the intervention of nanobiotechnology, which was undertaken in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Vegetables are good sources of natural antioxidants, such as carotenoids, vitamins, polyphenols, flavonoids and anthocyanins which are effective in quenching singlet oxygen and scavenging free radical, thereby preventing oxidation of biomolecules. This consequently prevents incidences of degenerative diseases like atherosclerosis, cancer and heart diseases (Olajire and Azeez 2011;Chandra et al 2014;Leonov et al 2015;Li et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Likewise, Medhe et al (2014) reported the enhancement of antioxidant properties of 3,6-dihydroxylflavanone when embedded in gold nanoparticles. A review by Li et al (2015) highlighted that nanoparticles enhanced absorption and bioavailability of phenolic compounds when used as nanocarriers for encapsulation of bioactive compounds. Raliya et al (2015) reported increase in antioxidant activity and lycopene contents of tomatoes grown with zinc and titanium nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Silver nanoparticles (AgNPs) biosynthesized using pod extract of Cola nitida enhances antioxidant activity and phytochemical composition of Amaranthus caudatus Linn

2017

View full text Add to dashboard Cite

This study investigates the influence of different concentrations of AgNPs biologically synthesized using pod extract of Cola nitida on antioxidant activity, phenolic contents, flavonoid contents and compositions of Amaranthus caudatus L. AgNPs of 25, 50, 75, 100 and 150 ppm were utilized in growing A. caudatus while water was used as control. Delayed germination for two days was observed for A. caudatus grown with 150 ppm of AgNPs, while others showed no difference. There were 43.3, 38.7, 26.7 and 6.48% improvements in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant activity of A. caudatus grown with 25, 50, 75 and 100 ppm of AgNPs, respectively, compared to control. Antioxidant activity of A. caudatus grown with AgNPs reduced with increase in the concentrations of AgNPs. A. caudatus grown with 50 ppm of AgNPs was the most potent with the least IC 50 of 0.67 mg/ml. Significant improvements obtained for phenolic and flavonoid contents grown with AgNPs were concentration dependent. Enhancements of 21.9, 68.19, and 1.98% in phenolic contents were achieved in treatments with 25, 50 and 75 ppm AgNPs, respectively, while 32.58, 35.80, and 7.20% improvement in flavonoids were obtained for 25, 50 and 100 ppm treatments, respectively. Kaempferol and quercetin were the most abundant flavonoids in A. caudatus treated with 50 ppm of AgNPs, showing the highest flavonoid composition. This further confirms A. caudatus grown with 50 ppm of AgNPs as the most potent. This study has shown that concentration-dependent AgNPs can be used to boost antioxidant activity and phytochemical contents of vegetables.

show abstract

“…Some authors [330,332] have revealed that a combination of other wall materials and other modifiers (as oxygen scavengers, antioxidants, chelating agents, and surfactants) increases the encapsulation efficiencies. [131,[328][329][330][331][332][333][334][335][336][337][338][339][340][341][342] summarizes some selected reviews on anthocyanin, polyphenol and bioactive compounds encapsulation. In last years, the use of biodegradable polymeric nanoparticles has attracted the interest of researches [337] due to their good biocompatibility, easy design and preparation, structure variations and interesting biomimetic characters.…”

Section: Encapsulation Of Anthocyaninsmentioning

confidence: 99%

Antioxidant Capacity of Anthocyanin Pigments

Martín¹,

Kuskoski²,

Navas³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

View full text Add to dashboard Cite

Anthocyanins are a family of natural pigments classified into the group of flavonoids, considered to be responsible for the color and taste of many fruits and vegetables, i.e. berries. Anthocyanins are common components of the human diet. Besides their interest as colorant because of their coloring properties, the study of anthocyanin compounds stems from their wide applicability in the prevention and even in the treatment of various human diseases. However, various aspects of the pharmacological roles of anthocyanins remain in the dark, having still several obstacles to the development of robust diets or prescribing lines on consumption of anthocyanins. The chemical structure of anthocyanins determines in large measure its capacity and efficacy as an antioxidant agent. In this study, the following aspects are reviewed: the antioxidant effect of anthocyanin pigments; the oxidative stress, the bioavailability after intake and biological aspects of anthocyanins, the method for measuring the antioxidant activity of anthocyanins, the relationship between structure and activity; and the influence of the anthocyanins in the antioxidant activity of wines. Finally an overview of some potential uses in food industry is attempted mainly focusing in the anthocyanin encapsulation topic. Attention has been paid to the more recent publications in the field.

show abstract

A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals

Cited by 305 publications

References 185 publications

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

Silver nanoparticles (AgNPs) biosynthesized using pod extract of Cola nitida enhances antioxidant activity and phytochemical composition of Amaranthus caudatus Linn

Antioxidant Capacity of Anthocyanin Pigments

Contact Info

Product

Resources

About