A Review: Thiazines Derivatives Treated as Potential Antimicrobial Agents

Abstract

In recent days, heterocycles and their derivatives have become strong reflection in medicinal research and pharmaceutical fields because of theirpractical pharmacological and biological activities. Organic compounds; mainly heterocyclic compounds are wealthy in natural world and containextra value because their structural subunits are established in many natural products such as enzymes, vitamins, antibiotics, acids, and hormones.Thiazine nucleuses found in compounds have variety of pharmacological activities such as antitumor, antimicrobial, antibacterial, antifungal, antiviral,and anti-inflammatory. This review spotlight on the substituted thiazines with possible antimicrobial activities that are at the present in development.Keywords: Antibacterial, Substituted thiazines, Antimicrobial agents.

Evaluation of the Physicochemical, Antioxidant, and Antibacterial Properties of Tunichrome Released from Phallusia nigra Persian Gulf Marine Tunicate

“…In addition, other pharmaceutical properties such as sedative, analgesic, antipyretic, anticonvulsant, antitubercular, antitumor, and antimalarial properties of 4-phenyltetrahydro-1,3-oxazine-2-thione [41], antitumor and anti-inflammatory properties of (+)-trans-3,4-dimethyl-2-phenyltetrahydro-1,4-thiazine [54], antitrypanosomal properties of hydrazinecarbothioamide, 2-[1-(4-nitrophenyl)ethylidene]- [55], and anticancer, antiproliferative, and anti-inflammatory properties of spirost-8-en-11-one,3-hydroxy-,(3β, 5α, 14β.20β, 22β, 25R)- [56,57] were reported previously.…”

Nematicidal Characterization of Newly Synthesized Thiazine Derivatives Using Caenorhabditis elegans as the Model Organism

“…Thio analogue of morpholine which is called thiomorpholine is the reduced form of thiazine. Some of the thiazine analogues like benzothiazine, phenothiazine, and benz fused analogues of thiazine are of much potential interest owing to their dynamic therapeutic properties. , The diverse pharmaceutical profile of thiazine is due to N–C–S linkage present in its structure, and owing to this consideration, N–C and C–S linkage relationships are employed for different dyes, tranquilizers, and antitumor, antitubercular, and antimicrobial activities . Moreover, nitrogen affords basic character to thiazine; due to this, it acts as a backbone of cephalosporin, and the thiazine structural unit is also part of various alkaloids like hormones, vitamins, and antibiotics .…”

“…5,6 The diverse pharmaceutical profile of thiazine is due to N−C−S linkage present in its structure, and owing to this consideration, N−C and C−S linkage relationships are employed for different dyes, tranquilizers, and antitumor, antitubercular, and antimicrobial activities. 7 Moreover, nitrogen affords basic character to thiazine; due to this, it acts as a backbone of cephalosporin, and the thiazine structural unit is also part of various alkaloids like hormones, vitamins, and antibiotics. 8 Benz fused thiazine has displayed better therapeutic potential against multifactorial diseases like diabetic complications, alzheimers, inflammatory conditions, cardiovascular diseases, and tuberculosis.…”

“…9 Detailed literature survey about thiazine indicates that it is a versatile motif owing to its potential for antifungal, antitubercular, antibacterial, antiviral, anticonvulsant, antimalarial, antipsychotic, and anti-inflammatory activities. 4,7,10 Until now, no one has published thiazine analogues as antinematodal agents; in the present work, all analogues were evaluated against nematode in order to check out the nematicidal potential and cytotoxic profile of thiazine.…”

Recent Advances in Synthesis and Medicinal Evaluation of 1,2‐Benzothiazine Analogues

“…Here in this review, therapeutic applications of 1,2‐benzothiazines in the arena of anti‐inflammatory, [23–37] anticancer, [38–56] antimicrobial, [57–62] antioxidant, [56,58,63–66] antidiabetic, [67–74] nor‐A efflux pump inhibitor, [75] antiepileptic, [76] anti‐arthritis, [77] anti‐HIV‐1, [78–81] alkaline phosphate inhibitors, [82] anti‐monoamine oxidase, [83] anti‐11β‐hydroxysteroid dehydrogenase, [84–85] calpain‐1 inhibitors, [86–87] and hepatitis virus‐C [88–89] along with their corresponding synthesis have been visualized. The prominence attained by derivatives of thiazole [90–91] and thiazine [15,92] lead researchers to construct medications like alpelisib and prochlorperazine maleate and a lot more (Figure 1).…”