A Review On Zno-Based Electrical Biosensors for Cardiac Biomarker Detection

Shanmugam, Nandhinee Radha; Muthukumar, Sriram; Prasad, Shalini

doi:10.4155/fsoa-2017-0006

Cited by 69 publications

(44 citation statements)

References 92 publications

(127 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Such nanotools indeed could be intrinsically toxic (Bisht and Rayamajhi, 2016), e.g., through the release of metal ions, or could be remotely activated to achieve cell death, as in the photothermal and photodynamic therapies (Lim et al, 2015). Zinc Oxide (ZnO) in particular has raised researchers' interest thanks to its biocompatibility and peculiar piezoelectric and semiconductive properties (Jiang et al, 2018;Racca et al, 2018) useful for its exploitation for imaging (Jiang et al, 2011), biosensing (Sanginario et al, 2016;Shanmugam et al, 2017;Stassi et al, 2017), tissue engineering (Laurenti and Cauda, 2017) and drug delivery (Laurenti and Cauda, 2018;Martínez-Carmona et al, 2018) purposes. Remarkably, ZnO nanoparticles are also studied for their intrinsic anticancer properties thanks to their selective toxicity toward cancer cells (Bisht and Rayamajhi, 2016).…”

Section: Introductionmentioning

confidence: 99%

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Racca

Limongi

Vighetto

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

In the last years, different nanotools have been developed to fight cancer cells. They could be administered alone, exploiting their intrinsic toxicity, or remotely activated to achieve cell death. In the latter case, ultrasound (US) has been recently proposed to stimulate some nanomaterials because of the US outstanding property of deep tissue penetration and the possibility of focusing. In this study, for the first time, we report on the highly efficient killing capability of amino-propyl functionalized ZnO nanocrystals (ZnO NCs) in synergy with high-energy ultrasound shock waves (SW) for the treatment of cancer cells. The cytotoxicity and internalization of ZnO NCs were evaluated in cervical adenocarcinoma KB cells, as well as the safety of the SW treatment alone. Then, the remarkably high cytotoxic combination of ZnO NCs and SW was demonstrated, comparing the effect of multiple (3 times/day) SW treatments toward a single one, highlighting that multiple treatments are necessary to achieve efficient cell death. At last, preliminary tests to understand the mechanism of the observed synergistic effect were carried out, correlating the nanomaterial surface chemistry to the specific type of stimulus used. The obtained results can thus pave the way for a novel nanomedicine treatment, based on the synergistic effect of nanocrystals combined with highly intense mechanical pressure waves, offering high efficiency, deep and focused tissue penetration, and a reduction of side effects on healthy cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Racca

Limongi

Vighetto

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Several reports have demonstrated the application of ZnO as biosensors, i.e. in DNA immobilization [180], in glucose level detection [176,177,181], for cardiac biomarker detection [179,182,183] and also for cancer diagnostic [178,184,185].…”

Section: Zinc Oxidementioning

confidence: 99%

Metal oxide nanostructures for sensor applications

Nunes

Pimentel

Gonçalves

et al. 2019

Semicond. Sci. Technol.

242

119

View full text Add to dashboard Cite

Human health, environmental protection and safety are just a few examples of current humankind main concerns, that drive the scientific community to develop sensors able to precisely monitor and alert to possible harms in real time. Over the years, semiconductor metal oxide-based materials have been largely employed as sensors dedicated to several applications, being particularly interesting at the nanometer scale, since it is largely known that smaller crystallite size enhances sensor's performance. Moreover, these materials are highly appealing as they can be produced by low-cost wet-chemical synthesis routes and are in general nontoxic, earth abundant and low-cost. This manuscript extensively reviews the recent developments of nanostructured semiconductor metal oxide sensors ranging from gas to humidity sensors, including ultraviolet (UV) sensors and biosensors. Zinc oxide (ZnO), titanium dioxide (TiO2), tungsten trioxide (WO3), copper oxide (CuO and Cu2O), tin oxide (SnO and SnO2), and vanadium oxide (VO2, V2O5)-based sensors either as nanoparticles or as continuous films/layers are described. Their sensing properties are correlated to size, shape, presence of defects, doping elements, amongst other relevant parameters. Different techniques and methods of fabricating these materials are addressed. The review is concluded with novel approaches for functionalization and future perspectives for sensor developments.

show abstract

“…The underlying reasons behind their popularity are attributed to the synergistic effects on physical and, particularly, optical properties of the PSi/ZnO, which are derived from the combination of individual features of both semiconductors [17][18][19][20][21][22]. The improved catalytic activity, high charge carrier mobility and relatively high biocompatibility make the PSi/ZnO nanocomposite a perfect material for a reliable long-term multipurpose (bio)sensor [23][24][25][26]. Moreover, the outstanding properties of PSi/ZnO nanocomposites related to electroluminescence (EL) [27,28] and photoluminescence (PL) [29][30][31][32] can be tuned through morphology control, such as crystal size, porosity of PSi, and Si to ZnO ratio.…”

Section: Introductionmentioning

confidence: 99%

Porous Silicon-Zinc Oxide Nanocomposites Prepared by Atomic Layer Deposition for Biophotonic Applications

et al. 2020

View full text Add to dashboard Cite

In the current research, a porous silicon/zinc oxide (PSi/ZnO) nanocomposite produced by a combination of metal-assisted chemical etching (MACE) and atomic layer deposition (ALD) methods is presented. The applicability of the composite for biophotonics (optical biosensing) was investigated. To characterize the structural and optical properties of the produced PSi/ZnO nanocomposites, several studies were performed: scanning and transmission electron microscopy (SEM/TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), diffuse reflectance, and photoluminescence (PL). It was found that the ALD ZnO layer fully covers the PSi, and it possesses a polycrystalline wurtzite structure. The effect of the number of ALD cycles and the type of Si doping on the optical properties of nanocomposites was determined. PL measurements showed a “shoulder-shape” emission in the visible range. The mechanisms of the observed PL were discussed. It was demonstrated that the improved PL performance of the PSi/ZnO nanocomposites could be used for implementation in optical biosensor applications. Furthermore, the produced PSi/ZnO nanocomposite was tested for optical/PL biosensing towards mycotoxins (Aflatoxin B1) detection, confirming the applicability of the nanocomposites.

show abstract

A Review On Zno-Based Electrical Biosensors for Cardiac Biomarker Detection

Cited by 69 publications

References 92 publications

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Metal oxide nanostructures for sensor applications

Porous Silicon-Zinc Oxide Nanocomposites Prepared by Atomic Layer Deposition for Biophotonic Applications

Contact Info

Product

Resources

About