A review on various plant-derived nanoemulgels and their applications

Abstract

Nanoemulgel is an emergent and promising drug delivery system used nowadays in the pharmaceutical industry. As a novel transdermal drug delivery tool, the applications of nanoemulgel have increasingly been used due to their unique characteristic properties and benefits over other oral and topical drug deliveries to avoid poor drug bioavailability and pharmacokinetic variations. These nanoemulgels are principally oil-in-water nanoemulsions gelled with a certain gelling agent in them. Plant extracts provide remarkable therapeutic options to manage different disease conditions due to their various pharmacological activities such as antioxidant, anti-inflammatory, anti-cancer, antibacterial, etc. However, the poor solubility and low bioavailability of lipophilic phytochemicals in plant extracts are two major issues in developing plant-derived formulations. In the past years, pharmaceutical research has focused more on nano-scale delivery systems to overcome the above problems by improving the delivery of herbal extracts and they have also reported nanoemulgel as a good vehicle for lipophilic and poorly soluble drugs. Therefore, the objective of this review is to discuss recent studies and applications of plant-derived nanoemulgels.

Nanotecnologia: Revisão Integrativa Sobre Uso De Nanoemulgéis Em Cosmecêuticos

“…Os gelificantes são introduzidos na formulação para transformar o estado líquido da nanoemulsão e resolver os problemas de baixa viscosidade e espalhabilidade limitada, facilitando a aplicação, a bioadesão, e administração percutânea de ativos. São exemplos práticos a carboximetilcelulose de sódio, a hidroxipropilmetilcelulose, carbômeros e polissacarídeos derivados de plantas (FERNANDO et al,2022;OJHA et al, 2022;SULTANA et al, 2022;TAHA et al, 2022;DONTHI et al, 2023;LAL et al, 2023). A Figura 1 representa etapas de produção dos nanoemulgéis.…”

“…Outro fato interessante, acerca das nanoemulsões, é que as gotículas da fase dispersam possuem carga elétrica devido a presença dos vários agentes emulsificantes e estabilizantes. A magnitude da repulsão entre as gotículas aumenta com o potencial zeta, essa propriedade aumenta a estabilidade da formulação, ou seja, as gotículas não conseguem se agregar devido elevado potencial zeta, assim, a presença de tensoativos aniônicos ou catiônicos são cruciais para a estabilidade da nanoelumsão (FERNANDO et al,2022;OJHA et al, 2022;SULTANA et al, 2022;TAHA et al, 2022;DONTHI et al, 2023;LAL et al, 2023).…”

“…Quando comparado com emulsões convencionais ou macroemulsões, cujo diâmetro das gotículas é maior que 500nm, as nanoemulsões se mostram mais estáveis não apresentando sinais de floculação, sedimentação e coalescência, por conta da estabilização promovida pela presença de tensoativos e cotensoativos. São usadas como transportadoras de ativos, para aumento da vida útil e textura de produtos (RAI et al, 2018;OJHA et al, 2022;FERNANDO et al, 2022;DONTHI et al, 2023).…”

“…Fernando et al,2022 A review on various plant-derived nanoemulgels and their applicationsWorld Journal of Advanced Research and Review Ojha et al, 2022 Nanoemulgel: a promising novel formulation for treatment of skin ailments Polymer Bulletin Sultana et al, 2022 Nanoemulgel: for promising topical and systemic delivery Drug Development Life Cycle Taha et al, 2022 Nanogels as Potential Delivery Vehicles in Improving the Therapeutic Efficacy of Phytopharmaceuticals Polymers Donthi et al, 2023 Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery Pharmaceutics Lal et al, 2023 An Overview of Nanoemulgels for Bioavailability Enhancement in Inflammatory Conditions via Topical Delivery Pharmaceutics Fonte: Próprios autores.…”