A Review on Type 2 Diabetes Mellitus Associated With Cognitive Disfunction and Dementia and Future Perspective

Abstract

Type 2 diabetes has previously been established as an independent risk for the development of both cognitive impairment and dementia. In their study, published in Neurology, the researchers wanted to investigate how inflammation, blood flow regulation in the brain and cognitive decline were related in people with the metabolic disorder.Diabetes mellitus affects millions of people, causing many complications. Recent studies have shown a link between diabetes and mild cognitive impairment (CI) in persons with earlier onset and greater severity of diabetes. Although the pathophysiology of CI is multifactorial, there is stronger evidence that lack of glycemic control resulting in hypo or hyperglycemia leads to CI among diabetic patients. With a growing geriatric population and increasing obesity trends in India, the prevalence of diabetes and the related CI, caregiving could be a challenge. Understanding the predisposing factors and the link between diabetes and CI or dementia can help improve the quality of life of diabetic individuals.