A review on traditional uses, phytochemistry and pharmacological activities of the genus Ballota

Morteza‐Semnani, Katayoun; Ghanbarimasir, Zahra

doi:10.1016/j.jep.2018.12.001

Cited by 16 publications

(16 citation statements)

References 102 publications

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“…Hispanolone is a labdane diterpenoid isolated from Ballota hispanica , a plant species widely distributed in Spain (Savona et al, 1978). Several species of the genus Ballota are used in folk medicine with therapeutic purposes (Morteza-Semnani and Ghanbarimasir, 2019). Thus, effects as antiemetics, expectorants, diuretics, antispasmodics, antibacterials, sedatives, vermifuges, among others have been described for some of these species.…”

Section: Discussionmentioning

confidence: 99%

α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

et al. 2019

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α-Hispanolol (α-H) is a labdane diterpenoid that has been shown to induce apoptosis in several human cancer cells. However, the effect of α-H in human glioblastoma cells has not been described. In the present work, we have investigated the effects of α-H on apoptosis, migration, and invasion of human glioblastoma cells with the aim of identifying the molecular targets underlying its mechanism of action. The results revealed that α-H showed significant cytotoxicity against human glioma cancer cell lines U87 and U373 in a concentration- and time-dependent manner. This effect was higher in U87 cells and linked to apoptosis, as revealed the increased percentage of sub-G1 population by cell cycle analysis and acquisition of typical features of apoptotic cell morphology. Apoptosis was also confirmed by significant presence of annexin V-positive cells and caspase activation. Pretreatment with caspase inhibitors diminishes the activities of caspase 8, 9, and 3 and maintains the percentage of viable glioblastoma cells, indicating that α-H induced cell apoptosis through both the extrinsic and the intrinsic pathways. Moreover, we also found that α-H downregulated the anti-apoptotic Bcl-2 and Bcl-xL proteins and activated the pro-apoptotic Bid and Bax proteins. On the other hand, α-H exhibited inhibitory effects on the migration and invasion of U87 cells in a concentration-dependent manner. Furthermore, additional experiments showed that α-H treatment reduced the enzymatic activities and protein levels of matrix metalloproteinase MMP-2 and MMP-9 and increased the expression of TIMP-1 inhibitor, probably via p38MAPK regulation. Finally, xenograft assays confirmed the anti-glioma efficacy of α-H. Taken together, these findings suggest that α-H may exert anti-tumoral effects in vitro and in vivo through the inhibition of cell proliferation and invasion as well as by the induction of apoptosis in human glioblastoma cells. This research describes α-H as a new drug that may improve the therapeutic efficacy against glioblastoma tumors.

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Section: Discussionmentioning

confidence: 99%

α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

et al. 2019

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“…Apigenin and quercetin are flavonoids that are most commonly found in a variety of fruits, vegetables, and herbs [94,95]. Treatment with apigenin at concentrations of 12.5∼100 μM can inhibit the proliferation of BCPAP cells arrested in the G2/M phase and induce autophagy via ROSmediated DNA damage [39].…”

Section: Flavonoidsmentioning

confidence: 99%

Herbal Active Ingredients: An Emerging Potential for the Prevention and Treatment of Papillary Thyroid Carcinoma

Yang

Chen

et al. 2020

BioMed Research International

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Papillary thyroid carcinoma (PTC) is the most common subtype of differentiated thyroid cancers in Asian coastal cities, where the patients have increased risk of potentially high or excessive iodine intake. Given the high metastasis and recurrence of patients with BRAFV600E mutation, the mortality rate of thyroid cancer has recently shown an upward trend. A variety of therapies, including surgery, radiotherapy, and chemotherapy, have been used to treat thyroid cancer, but these therapies still have limitations, including postoperative complications, drug resistance, poor efficacy, or serious side effects. Recent studies have shown the potential of active ingredients derived from herbal medicine in inhibiting PTC via various cell signaling pathways. Some plant-derived compounds, such as apigenin, genistein, and curcumin, are also known to prevent and treat PTC. This article summarizes the recent advances in the structure-functional impact of anti-PTC active ingredients and their effects on PTC cells and tumor microenvironments with an emphasis on their challenges from basic research to clinical practice.

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“…Despite the lack of scientific information regarding phenylethanoid glycosides in the Galeopsis genus, with the exception of G. pubescens, which contains martynoside and isomartynoside [16], lavandulifolioside, verbascoside, isoverbascoside, leonosides A and B, leucosceptoside A, and martynoside are frequent metabolites of Lamiaceous plants. For the tribe Stachydeae, which includes the Galeopsis genus, the phenylethanoid glycosides are taxonomic markers and have been found in Ballota [61], Lamium [62], Phlomis [63], Stachys [64], and Sideritis species [64]. Therefore, it was to be expected that verbascoside and its relatives would be found in Galeopsis species.…”

Section: Phenylethanoid Glycosidesmentioning

confidence: 99%

“…Phenylethanoid glycosides are widespread in the Lamiaceae family, especially in genera closely related to Galeopsis, such as Ballota [61], Lamium [62], Phlomis [63], and Stachys [64]. A high occurrence of verbascoside and isoverbascoside is characteristic of many species of Lamiaceae [75], especially the species belonging to the subfamily Stachyoideae [76].…”

Section: Acidic Flavone Glycosidesmentioning

confidence: 99%

Synanthropic Plants as an Underestimated Source of Bioactive Phytochemicals: A Case of Galeopsis bifida (Lamiaceae)

Оленников

2020

Plants

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Hemp nettle (Galeopsis bifida Boenn.) is a synanthropic species of the Lamiaceae family that is widely distributed across Europe, Asia, and Siberia. Galeopsis bifida is deeply embedded in the ethnomedical tradition of Asian healers; however, this plant is still poorly characterized, both chemically and pharmacologically. To study Siberian populations of G. bifida, we used high-performance liquid chromatography with photodiode array and electrospray triple quadrupole mass detection for metabolic profiling. Ninety compounds were identified, including iridoid glycosides, phenylethanoid glycosides, hydroxycinnamates, and flavone glycosides, most of which were identified in G. bifida for the first time, while some phenolics were found to have potential chemotaxonomic significance in the Lamiaceae family and Galeopsis genus. An unequal quantitative distribution of the selected metabolites was observed within separate organs of the G. bifida plant, characterized by high accumulation of most compounds within the aerial part of the plant (leaves, flowers). Analysis of the content of specific chosen compounds within the leaves of different populations of G. bifida from Eastern Siberia revealed the existence of two chemical types based on metabolic specifics: the southern type accumulates flavone glucuronides, while the northern type tends to accumulate high levels of phenylpropanoids and acylated flavone glucosides. The first study of the bioactivity of G. bifida extract demonstrated that the herb has low toxicity in acute experiments and expresses antioxidant potential against free radicals in the form of DPPH˙, ABTS˙+, and superoxide radical, as well as high ferric reducing antioxidant power, oxygen radical absorbance capacity, and protective action in the carotene bleaching assay. In general, our results suggest the herb of G. bifida as a new, prospective synanthropic plant for medical application.

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A review on traditional uses, phytochemistry and pharmacological activities of the genus Ballota

Cited by 16 publications

References 102 publications

α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

Herbal Active Ingredients: An Emerging Potential for the Prevention and Treatment of Papillary Thyroid Carcinoma

Synanthropic Plants as an Underestimated Source of Bioactive Phytochemicals: A Case of Galeopsis bifida (Lamiaceae)

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