A review on the synthesis and biological relevance of benzo[b]thiophene derivatives

Total Synthesis of Racemic Thieno[3,2-f]thiochromene Tricarboxylate, a Luciferin from Marine Polychaeta Odontosyllis undecimdonta

“…For further research of Odontosyllis luminescence mechanisms, the synthetic pathway to the molecule required an investigation due to the low stability and low amount of the product in its natural source. Although synthetic attempts at various benzothiophene and thiochromene derivatives have been described, there are no reports toward the synthesis of thieno­[3,2- f ]­thiochromenes. In this paper, we disclose a convergent approach in which the thiocarbon skeleton is accessed via formation of a thiochromene ring with the use of tandem condensation between bifunctional thiol-phosphonate and benzothiophene-quinone.…”