A review on the structure and pharmacological activity of phenylethanoid glycosides

Tian, Xiuyu; Li, Maoxing; Lin, Tong; Qiu, Yan; Zhu, Yuting; Li, Xiaolin; Tao, Wendi; Wang, Peng; Ren, Xiao-Xia; Chen, Liping

doi:10.1016/j.ejmech.2020.112563

Cited by 67 publications

(30 citation statements)

References 205 publications

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“…The monoterpene glycosides betulalbuside A ( 91) and 1-hydroxylinaloyl 6-O-β-D-glucopyranoside (92) were isolated from few Phlomis species. Diterpenoids belong to pimarane-type and labdane-type (94)(95). Amanicadol ( 93), a pimarane-type diterpene, was first reported from P. amanica [51].…”

Section: Terpenoids (91-100)mentioning

confidence: 99%

“…The potential inhibitory effect of verbascoside (= acteoside) (23) on neurotoxicity has been studied, and the compound has been suggested to be useful in the treatment of neurological diseases such as parkinsonism [92]. The recent studies have focused on the chemistry, pharmacological activity, and pharmacokinetics of PhEts [93][94][95]. Verbascoside (= acteoside) (23), as a widely distributed PhEt in the plant kingdom, has been discussed in many perspectives, including biosynthesis, production using biotechnological methods and pharmacological activities, molecular features, and principal photoprotective activities in human keratinocytes [93].…”

Section: Phenylethanoid Glycosides (Groupsmentioning

confidence: 99%

“…In 2016, Xue and Yang reviewed the biological activities such as neuroprotective, anti-inflamma- tory, antioxidant, antibacterial and antiviral, cytotoxic, immunomodulatory properties, and enzyme inhibitory effects, as well as pharmacokinetic properties of the new PhEts isolated between 2005 and 2015 [94]. A recent review reported the structures of 375 PhEts including 57 mono-, 143 di-, 161 tri-, and 14 tetraglycosidic structures, their plant sources, biosynthesis, and chemical synthesis together with their pharmacological activities in a wider perspective [95]. Finally, some Phlomis oils have been tested for various biological activities.…”

Section: Phenylethanoid Glycosides (Groupsmentioning

confidence: 99%

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Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils

Çalış

Başer

2021

Planta Med

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As the sixth-largest Angiosperm family, Lamiaceae contains more than 245 genera and 7886 species that are distributed worldwide. It is also the third-largest family based on the number of taxa in Turkey where it is represented by 46 genera and 782 taxa with a high endemism ratio (44%). Besides, Lamiaceae are rich in plants with economic and medicinal value containing volatile and nonvolatile compounds. Many aromatic plants of Lamiaceae such as Salvia, Sideritis, Stachys, Phlomis, and Teucrium species are used in traditional herbal medicine throughout Turkey as well as in other Mediterranean countries. Salvia (Sage tea “Adaçayı”), Sideritis (Mountain tea “Dağçayı”), Stachys (Hairy Tea “Tüylü Çay”), and Phlomis (Turkish sage “Çalba or Şalba”) are the largest genera that are used as herbal teas. This review focuses on the volatile and nonvolatile compounds of Lamiaceae from the genera Phlomis and Eremostachys of the subfamily Lamioideae with emphasis on iridoids, phenylethanoid glycosides, and essential oils.

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Section: Terpenoids (91-100)mentioning

confidence: 99%

Section: Phenylethanoid Glycosides (Groupsmentioning

confidence: 99%

Section: Phenylethanoid Glycosides (Groupsmentioning

confidence: 99%

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Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils

Çalış

Başer

2021

Planta Med

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“…Currently, a great amount of reports have demonstrated the neuroprotection, bone metabolism regulation, hepatoprotection, anti‐inflammation, anticancer, antiaging, and antifatigue effects of CH as well as its primary components such as ECH and VB. Two recent reviews have summarized the pharmacological study progresses concerning PhGs 100,101 . Therefore, we herein principally emphasize the research on CH extract as well as its primary active compounds.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Cistanches Herba, from an endangered species to a big brand of Chinese medicine

Song

Zeng

Jiang

et al. 2021

Medicinal Research Reviews

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Cistanches Herba (CH, Chinese name: Roucongrong), is a very precious, tonic Chinese medicine. Cistanche deserticola and Cistanche tubulosa are the two commonly used species and authenticated in Chinese Pharmacopoeia. Due to the parasitic nature of Cistanche plants, the wild source was once endangered and listed in the Appendix II of Convention on International Trade in Endangered Species of Wild Fauna and Flora. However, after continuously struggling in the past decades, CH has grown up to a big brand of Chinese medicine featured with the cultivation area as 1.26 million mu, the annual output as 6000 tons, and the related industrial output value as more than 20 billion China Yuan, attributing to large‐scale cultivation and in‐depth phytochemical and pharmacological investigations. Noteworthily, great achievements have reached concerning the research and development of relevant products, such as modern drugs, traditional Chinese medicine prescriptions, and dietary supplements. The current review summarizes the research progresses concerning the distribution and cultivation, phytochemistry, pharmacology, metabolism and product development of CH in the past decades, and the emerging challenges and developing prospects are discussed as well.

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“…Phenylethanoid glycosides are phenolic derivatives which characterize genus Sideritis. Numerous pharmacolog-ical activities have been reported such as antioxidant, antiinflammatory, and anti-hypertensive effects 16 . Regarding their antioxidant properties, major mechanisms of action are through the direct scavenging of free radicals, metal chelation, and inhibition of ROS producing enzymes 17 .…”

Section: Phenylethanoid Glycosidesmentioning

confidence: 99%

Mountain tea (Sideritis plants): A potential anti-atherogenic agent?

Tomou¹,

Perrea²,

Skaltsa³

2021

JAPT

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Atherosclerosis consists the leading cause of cardiovascular diseases. Over the last years, medicinal plants are considered as efficient agents in the prevention and adjuvant therapy of atherosclerosis. Mountain tea (Sideritis plants) is used as traditional remedy against common cold and gastrointestinal disorders. Its beneficial properties are attributed to its rich bioactive constituents. Polyphenols exhibit a broad range of pharmacological activities such as antioxidant, anti-inflammatory and anti-atherosclerotic effects. The present review summarizes and discusses the potential of mountain tea as an anti-atherogenic agent based on its bioactive chemical compounds and their reported pharmacological activities.

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A review on the structure and pharmacological activity of phenylethanoid glycosides

Cited by 67 publications

References 205 publications

Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils

Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils

Cistanches Herba, from an endangered species to a big brand of Chinese medicine

Mountain tea (Sideritis plants): A potential anti-atherogenic agent?

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