A review on the role of oncogenic lncRNA OIP5-AS1 in human malignancies

Ghafouri‐Fard, Soudeh; Dashti, Sepideh; Farsi, Molood; Hussen, Bashdar Mahmud; Taheri, Mohammad

doi:10.1016/j.biopha.2021.111366

Cited by 22 publications

(17 citation statements)

References 45 publications

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“…lncRNA CCAT1 expression has been reported to be upregulated in ESCC tissues, to promote cell proliferation and migration by mediating the SPRY4/HOXB13 axis via sponging miR-7, and to be associated with a poor survival in patients with ESCC ( 22 ). OIP5-AS1 has been reported to regulate carcinogenesis in various types of cancer ( 23 ). In cervical cancer, silencing of OIP5-AS1 markedly decreases cell proliferation, colony formation and invasion by increasing the expression of integrin subunit a6 through sponging miR-143-3 ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA OIP5‑AS1 promotes the progression of esophageal cancer by regulating miR‑30a/VOPP1 expression

Chen

Fang

et al. 2021

Oncol Lett

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Long non-coding RNAs (lncRNAs) serve an important role in the development of esophageal cancer (EC), which is the eighth most common type of cancer worldwide. lncRNA opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is associated with human malignancy. However, the biological roles of OIP5-AS1 in the development of EC remain unclear. In the present study, transfection was conducted, and reverse transcription-quantitative PCR and western blot analysis were used for the detection of mRNA and protein expression, respectively. Furthermore, dual-luciferase reporter and RNA immunoprecipitation assays were used to study the interaction between miRNA and lncRNA or genes. The results revealed that OIP5-AS1 expression in EC tissues and cultured EC cells was upregulated, microRNA-30a (miR-30a) expression was downregulated. OIP5-AS1-knockdown suppressed the proliferation, migration and invasion of EC9706 and EC109 cells. miR-30a was confirmed to interact with OIP5-AS1, and miR-30a-mimics transfection ameliorated the effects of OIP5-AS1 in EC cells. Vesicular overexpressed in cancer prosurvival protein 1 (VOPP1) was verified as the direct target of miR-30a. VOPP1 expression was positively correlated with OIP5-AS1 expression in EC cells. Overexpression of VOPP1 ameliorated the negative effects of OIP5-AS1-knockdown on EC9706 and EC109 cells. In conclusion, OIP5-AS1 promoted the proliferation, migration and invasion of EC cells by increasing VOPP1 expression by sponging miR-30a.

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Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA OIP5‑AS1 promotes the progression of esophageal cancer by regulating miR‑30a/VOPP1 expression

Chen

Fang

et al. 2021

Oncol Lett

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“…One of the neighboring genes to OIP5 is OIP5-AS1 (OIP5 antisense RNA 1). According to GRCh38.p13 (Genome Reference Consortium Human Build 38 patch release 13) released in Feb 28, 2019 [61]. OIP5-AS1 encodes a long non-coding RNA (lnRNA) and possesses oncogenic activities via regulating a set of microRNAs [61].…”

Section: Discussionmentioning

confidence: 99%

“…According to GRCh38.p13 (Genome Reference Consortium Human Build 38 patch release 13) released in Feb 28, 2019 [61]. OIP5-AS1 encodes a long non-coding RNA (lnRNA) and possesses oncogenic activities via regulating a set of microRNAs [61]. For instance, OIP5-AS1 was reported to sponge miR-143-3P to enhance cervical cancer [62] and miR-186a-5p to facilitate hepatoblastoma [63].…”

Section: Discussionmentioning

confidence: 99%

Prognostic and Therapeutic Potential of the OIP5 Network in Papillary Renal Cell Carcinoma

Chow

et al. 2021

Cancers

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Papillary renal cell carcinoma (pRCC) is an aggressive but minor type of RCC. The current understanding and management of pRCC remain poor. We report here OIP5 being a novel oncogenic factor and possessing robust prognostic values and therapeutic potential. OIP5 upregulation is observed in pRCC. The upregulation is associated with pRCC adverse features (T1P < T2P < CIMP, Stage1 + 2 < Stage 3 < Stage 4, and N0 < N1) and effectively stratifies the fatality risk. OIP5 promotes ACHN pRCC cell proliferation and xenograft formation; the latter is correlated with network alterations related to immune regulation, metabolism, and hypoxia. A set of differentially expressed genes (DEFs) was derived from ACHN OIP5 xenografts and primary pRCCs (n = 282) contingent to OIP5 upregulation; both DEG sets share 66 overlap genes. Overlap66 effectively predicts overall survival (p < 2 × 10−16) and relapse (p < 2 × 10−16) possibilities. High-risk tumors stratified by Overlap66 risk score possess an immune suppressive environment, evident by elevations in Treg cells and PD1 in CD8 T cells. Upregulation of PLK1 occurs in both xenografts and primary pRCC tumors with OIP5 elevations. PLK1 displays a synthetic lethality relationship with OIP5. PLK1 inhibitor BI2356 inhibits the growth of xenografts formed by ACHN OIP5 cells. Collectively, the OIP5 network can be explored for personalized therapies in management of pRCC patients.

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“…The mechanism of action by which OIP5-AS1 represses p15, p16, p18 and p19 is yet to be determined. However, it is known that OIP5-AS1 acts as a sponge for a few dozen miRNAs and competes against them (9). miRNAs participate in the posttranscriptional regulation of gene expression.…”

Section: Discussionmentioning

confidence: 99%

OIP5-AS1Promotes Proliferation of Non-small-cell Lung Cancer and Head and Neck Squamous Cell Carcinoma Cells

Kotake

Matsunaga

Wakasaki

et al. 2021

Cancer Genomics Proteomics

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Background/Aim: The long noncoding RNA OIP5 antisense RNA 1 (OIP5-AS1) is overexpressed in various cancer types, such as lung cancer, hepatoblastoma and cervical cancer, and functions to accelerate cell proliferation, invasion and migration. Here, we investigated the roIe of OIP5-AS1 in cell-cycle progression of H1299 and A549 non-small cell lung cancer cells, and FaDu and CAL27 head and neck squamous cell carcinoma cells. Materials and Methods: The cells were transfected with small interfering RNA and subjected to cell-cycle analysis and reverse-transcription quantitative polymerase chain reaction (RT-qPCR). Results: Silencing of OIP5-AS1 suppressed the proliferation of H1299, A549, FaDu and CAL27 cells. RT-qPCR and cell-cycle analysis revealed that silencing OIP5-AS1 increased the expression of CDK inhibitors, such as p15, p16, p18 and p19, resulting in G1phase arrest. Conclusion: OIP5-AS1 regulates G1-phase progression by repressing CDK inhibitors and, thus, promotes the proliferation of H1299, A549, FaDu and CAL27 cells.OPA-interacting protein 5 antisense transcript 1 (OIP5-AS1) is a long noncoding RNA (lncRNA) identified as the mammalian homolog of cyrano in zebrafish. In zebrafish, cyrano is essential for embryonic development (1). We previously showed that silencing human OIP5-AS1 inhibited the proliferation of HeLa cells by causing cell-cycle arrest at the G 2 /M phase, implying that human OIP5-AS1 functions to promote cell proliferation (2). Recent studies with clinical cancer specimens clarified that OIP5-AS1 is overexpressed in various cancer types such as of the breast, lung, cervix and bladder, as well as glioma, osteosarcoma and hepatoblastoma (3). OIP5-AS1 also participates in both positive and negative regulation of cell proliferation in cervical cancer (2, 4). Moreover, in many different human cancer cell types, including those of lung cancer (5), osteosarcoma (6), glioma (7) and hepatoblastoma (8), OIP5-AS1 functions to accelerate cell proliferation, invasion, migration and prevent apoptosis, so it is thought to function as an oncogene in these kinds of cancer. OIP5-AS1 acts as a sponge for many microRNAs (miRNAs) thereby inhibiting them, resulting in the regulation of WNT/β-catenin, PI3K/AKT serine/threonine kinase 1 and NOTCH signalling pathways (9).Cell proliferation is strictly regulated by the cell cycle. The progression of the cell cycle is accelerated by a series of complexes consisting of cyclins and cyclin-dependent kinases (CDKs) and is repressed by CDK inhibitors (CKIs) (10). CKIs comprise two groups, the INK4 family including p15, p16, p18 and p19 and the Cip/Kip family including p21, p27 and p57 (11). Forced expression of these CKIs results in G 1 phase arrest in the cell cycle. Regulation of the G 1 phase by cyclin/CDK complexes and CKIs is thought to be important for the regulation of cell proliferation. Recently, we revealed that a lncRNA, antisense non-coding RNA in the INK4 locus (ANRIL), functions as a positive regulator of G 1 -phase progression in head and neck squamous cell...

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A review on the role of oncogenic lncRNA OIP5-AS1 in human malignancies

Cited by 22 publications

References 45 publications

Long non‑coding RNA OIP5‑AS1 promotes the progression of esophageal cancer by regulating miR‑30a/VOPP1 expression

Long non‑coding RNA OIP5‑AS1 promotes the progression of esophageal cancer by regulating miR‑30a/VOPP1 expression

Prognostic and Therapeutic Potential of the OIP5 Network in Papillary Renal Cell Carcinoma

OIP5-AS1Promotes Proliferation of Non-small-cell Lung Cancer and Head and Neck Squamous Cell Carcinoma Cells

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