A review on the role of miRNA-324 in various diseases

Kadkhoda, Sepideh; Hussen, Bashdar Mahmud; Eslami, Solat; Ghafouri‐Fard, Soudeh

doi:10.3389/fgene.2022.950162

Cited by 6 publications

(2 citation statements)

References 80 publications

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“…Dysregulation of miR-324 has been described in a variety of tumor types and cancer cell lines (32). Most of studies have stated downregulation of miR-324 in these samples.…”

Section: Discussionmentioning

confidence: 99%

miRNAs in umbilical cord tissue in neonates with different birth weights: a pilot study

García-Muro,

Toledo-Gotor,

Pasamón-García

et al. 2024

Preprint

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Background: Birth weight has been defined as an indicator of perinatal health. miRNAs are small non-coding RNA molecules between 18 and 25 nucleotides that regulate gene expression. Specific miRNAs have been implicated in metabolic pathways that influence fetal growth, so their dysregulation may contribute to birth weight alterations. Our objective was to recover amplifiable miRNAs from umbilical cord tissue and to compare their expression among three groups of patients. Methods: The study was conducted in a sample 23 patients: 8 small for gestational age (SGA), 10 large for gestational age (LGA) and 5 appropriate for gestational age (AGA) subjects. Umbilical cord tissue samples were obtained immediately after childbirth, stored and then processed. miRNAs expression profile was analyzed in these samples through high-throughput sequencing. The results were assessed through bioinformatic analysis. Results: We identified significant differences in levels of 6 miRNAs. Compared with AGA and LGA, miR-324-3p was downregulated in SGA, miR-337-3p was upregulated in LGA in comparison to both SGA and AGA, miR-760 was downregulated in LGA compared to SGA and AGA, and miR-4707-3p, miR-548a-3p and miR-6733-5p were upregulated in both SGA and LGA in comparison to AGA. Most of these molecules could be associated with the transforming growth factor-beta signaling pathway. Conclusions: This exploratory study suggests that the expression of miRNAs in umbilical cord tissue is associated with birth weight. Our findings highlight the downregulation of miRNA-324-3p in SGA newborns, leading us to conclude that its decrease could serve as a marker for low birth weight.

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“…Dysregulation of miR-324 has been described in a variety of tumor types and cancer cell lines (32). Most of studies have stated downregulation of miR-324 in these samples.…”

Section: Discussionmentioning

confidence: 99%

miRNAs in umbilical cord tissue in neonates with different birth weights: a pilot study

García-Muro,

Toledo-Gotor,

Pasamón-García

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…miRNAs are involved in the response of cells to environmental stressors; thus, representing ideal markers to reflect on etiology fingerprint of the disease. Development of several diseases, including cancer, have been attributed to altered miRNA expression pattern (Kadkhoda et al, 2022a;Kadkhoda et al, 2022b). The altered miRNA expression patterns were reported to be observed before the obvious clinical symptoms or clear biopsy and image examination became evidenced (Zhang et al, 2020).…”

Section: Small Rna Deep Sequencing Of Circulating Rnas Discovers a Un...mentioning

confidence: 99%

Small RNA Deep Sequencing of Circulating Small RNAs Discovers a Unique Panel of microRNAs as Feasible and Reliable Biomarkers of Non-Small Cell Lung Cancers in Northern Thailand

Han,

Pornprasert,

Saeteng

et al. 2023

Asian Pac J Cancer Prev

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Objective: This study aimed to assess the practicality and reliability of utilizing microRNAs (miRNAs) as a potential screening and diagnosing tool for non-small cell lung cancers (NSCLCs) in Northern Thailand. Methods: Small RNA sequencing and a literature review was performed to obtain a list of serum miRNA candidates. Serum levels of these selected miRNA candidates were measured in patients with NSCLC and healthy volunteers by real-time RT-PCR and receiver operating characteristic curve (ROC) were used to assess diagnostic performance. Results: Sequencing data revealed 148 known miRNAs and 230 novel putative miRNAs in serum samples; 19 serum miRNAs were significantly downregulated and 242 were upregulated. Seven miRNAs selected according to sequencing data and 11 miRNAs according to previous reports were evaluated in training cohort (45 lung cancer patients, 26 controls) and 6 miRNAs were found differentially expressed (p < 0.05, Mann Whitney U test) and associated (p < 0.05, Chi-square test) with NSCLC development. Further analysis and verification identified an optimal combination of 4 miRNAs composed of hsa-miR23a, hsa-miR26b, hsa-miR4488 and novel-130 to provide the optimal AUC of 0.901±0.034. Detection of serum miRNA by real-time RT-PCR showed good reproducibility with the coefficient of variation (CV) ≤ 4%. The optimal screening miRNAs panel was primarily identified through sequencing data of local patient population, thus indicating that the etiology of NSCLCs may differ from one population to other and thus require a unique panel of miRNAs for their identification. Conclusion: Circulating miRNA is a feasible screening tool for NSCLCs. Nevertheless, populations with different lung cancer etiology may need to identify their own most suitable miRNA panel.

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Urinary miRNAs Predict Metastasis in Patients With Clinically Localized Clear Cell Renal Cell Carcinoma Treated With Nephrectomy

Borges dos Reis,

Shu,

et al. 2024

Clinical Genitourinary Cancer

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A review on the role of miRNA-324 in various diseases

Cited by 6 publications

References 80 publications

miRNAs in umbilical cord tissue in neonates with different birth weights: a pilot study

miRNAs in umbilical cord tissue in neonates with different birth weights: a pilot study

Small RNA Deep Sequencing of Circulating Small RNAs Discovers a Unique Panel of microRNAs as Feasible and Reliable Biomarkers of Non-Small Cell Lung Cancers in Northern Thailand

Urinary miRNAs Predict Metastasis in Patients With Clinically Localized Clear Cell Renal Cell Carcinoma Treated With Nephrectomy

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