A Review on the Mechanism of Tuina Promoting the Recovery of Peripheral Nerve Injury

Liu, Zhifeng; Wang, Hourong; Yu, Tianyuan; Yi, Jae-Seon; Zhang, Yingqi; Liu, Di; Xu, Yajing; Guan, Qian; Lu, Mengqian

doi:10.1155/2021/6652099

Cited by 8 publications

(14 citation statements)

References 37 publications

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“…Reports have suggested that Tuina would improve functional outcomes following peripheral nerve injury repair (Z. Liu et al, 2021;. However, it is not well understood whether the long-lasting cortical plasticity is involved in the improvement of function after Tuina therapy.…”

Section: Discussionmentioning

confidence: 99%

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Tuina therapy promotes behavioral improvement and brain plasticity in rats with peripheral nerve injury and repair

Zhang

Hua

et al. 2023

Brain and Behavior

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IntroductionTuina is currently one of the popular complementary and alternative methods of rehabilitation therapy. Tuina can improve patients' pain and mobility function. However, the underlying physiological mechanism remains largely unknown, which might limit its further popularization in clinical practice. The aim of this study is to explore the short‐term and long‐term changes in brain functional activity following Tuina intervention for peripheral nerve injury repair.MethodsA total of 16 rats were equally divided into the intervention group and the control group. Rats in the intervention group received Tuina therapy applying on the gastrocnemius muscle of the right side for 4 months following sciatic nerve transection and immediate repair, while the control group received nerve transection and repair only. The block‐design functional magnetic resonance imaging scan was applied in both groups at 1 and 4 months after the surgery. During the scan, both the injured and intact hindpaw was electrically stimulated according to a “boxcar” paradigm.ResultsWhen stimulating the intact hindpaw, the intervention group exhibited significantly lower activation in the somatosensory area, limbic/paralimbic areas, pain‐regulation areas, and basal ganglia compared to the control group, with only the prefrontal area showing higher activation. After 4 months of sciatic nerve injury, the control group exhibited decreased motor cortex activity compared to the activity observed at 1 month, and the intervention group demonstrated stronger bilateral motor cortex activity compared to the control group.ConclusionTuina therapy on the gastrocnemius muscle of rats with sciatic nerve injury can effectively alleviate pain and maintain the motor function of the affected limb. In addition, Tuina therapy reduced the activation level of pain‐related brain regions and inhibited the decreased activity of the motor cortex caused by nerve injury, reflecting the impact of peripheral stimulation on brain plasticity.

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Section: Discussionmentioning

confidence: 99%

“…As more studies regarding to Tuina therapy in the treatment of peripheral nerve injury have been reported, investigations on brain plasticity have become essential for a better understanding of its effects and appropriate application in clinical practice (Z. Liu et al, 2021;.…”

Section: Introductionmentioning

confidence: 99%

Tuina therapy promotes behavioral improvement and brain plasticity in rats with peripheral nerve injury and repair

Zhang

Hua

et al. 2023

Brain and Behavior

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“…Phospholipids are the lipids containing phosphorus, mainly including phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), and phosphatidic acid (PA) . Phospholipids are the basic components of cell membranes, nuclear membranes, and lipid membranes in animal or plant cells, as well as one of the components of nerve cells. , They can protect nerve cells, accelerate the transmission of biomedical information, and repair the damaged brain. , Due to the presence of both hydrophilic and lipophilic groups, phospholipids can be used to encapsulate, transport and sustainably release water-soluble, oil-soluble, and amphiphilic substances . For example, by combining polyphenols with phospholipids under certain conditions, a polyphenol–phospholipid complex can be obtained, which not only changes the physicochemical properties of polyphenols but also masks their unpleasant flavor and enhances their stability. , In recent years, such phospholipid complexes have been widely applied in many fields such as food, medicine, and cosmetics …”

Section: Introductionmentioning

confidence: 99%

Hydrolysis and Transport Characteristics of Phospholipid Complex of Alkyl Gallates: Potential Sustained Release of Alkyl Gallate and Gallic Acid

Wang,

Cai

et al. 2024

J. Agric. Food Chem.

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Phospholipid complexes of alkyl gallates (A-GAs) including ethyl gallate (EG), propyl gallate (PG), and butyl gallate (BG) were successfully prepared by the thin film dispersion method. HPLC-UV analysis in an everted rat gut sac model indicated that A-GAs can be liberated from phospholipid complexes, which were further hydrolyzed by intestinal lipase to generate free gallic acid (GA). Both A-GAs and GA are able to cross the membrane, and the hydrolysis rate of A-GAs and the transport rate of GA are positively correlated with the alkyl chain length. Especially, compared with the corresponding physical mixtures, the phospholipid complexes exhibit slower sustained-release of A-GAs and GA. Therefore, the formation of phospholipid complexes is an effective approach to prolong the residence time in vivo and additionally enhance the bioactivities of A-GAs and GA. More importantly, through regulating the carbon skeleton lengths, controlled-release of alkyl gallates and gallic acid from phospholipid complexes will be achieved.

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“…The goal of these maneuvers is to reduce pain while also having a direct impact on the underlying disease process. Tuina has been shown to be effective for many clinical conditions, such as cervical vertigo, [7] hypertension, [8] chronic fatigue syndrome, [9] chronic neck pain, [10] peripheral nerve injury, [11,12] headache, [13] and various musculoskeletal conditions. [14] It has also become an important treatment method for LBP.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of Tuina for chronic nonspecific low back pain: A PRISMA-compliant systematic review and meta-analysis

Yang

Woods

et al. 2023

Medicine

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Objective: Chronic nonspecific low back pain (CNLBP) is a serious medical and social problem resulting in functional decline and decreased work ability. Tuina, a form of manual therapy, has been sparsely used to treat patients with CNLBP. To systematically assess the efficacy and safety of Tuina for patients with CNLBP.Methods: Multiple English and Chinese literature databases were searched until September 2022 for randomized controlled trials (RCTs) of Tuina in the treatment of CNLBP. The methodological quality was assessed using the Cochrane Collaboration's tool, and certainty of the evidence was determined with the online Grading of Recommendations, Assessment, Development and Evaluation tool.Results: Fifteen RCTs with 1390 patients were included. Tuina demonstrated a significant effect on pain (SMD: −0.82; 95% CI −1.12 to −0.53; P < .001; I 2 = 81%) and physical function (SMD: −0.91; 95% CI −1.55 to −0.27; P = .005; I 2 = 90%) when compared to control. However, Tuina resulted in no significant improvement for quality of life (QoL) (SMD: 0.58; 95% CI −0.04 to 1.21; P = .07; I 2 = 73%;) compared to control. The Grading of Recommendations, Assessment, Development and Evaluation evidence quality was determined to be low level for pain relief, physical function, and QoL measurements. Only six studies reported adverse events; none were serious. Conclusion:Tuina might be an effective and safe strategy for treating CNLBP in terms of pain and physical function, but not for QoL. The study results should be interpreted with caution for their low-level evidence. More multicenter, large-scale RCTs with a rigorous design are required to further confirm our findings.

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A Review on the Mechanism of Tuina Promoting the Recovery of Peripheral Nerve Injury

Cited by 8 publications

References 37 publications

Tuina therapy promotes behavioral improvement and brain plasticity in rats with peripheral nerve injury and repair

Tuina therapy promotes behavioral improvement and brain plasticity in rats with peripheral nerve injury and repair

Hydrolysis and Transport Characteristics of Phospholipid Complex of Alkyl Gallates: Potential Sustained Release of Alkyl Gallate and Gallic Acid

Efficacy and safety of Tuina for chronic nonspecific low back pain: A PRISMA-compliant systematic review and meta-analysis

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