A review on the efficacy and medicinal applications of metal-based triazole derivatives

Sumrra, Sajjad Hussain; Habiba, Umme; Zafar, Wardha; Imran, Muhammad; Chohan, Zahid H.

doi:10.1080/00958972.2020.1839751

Cited by 45 publications

(13 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3] They have attracted the attention of researchers because of their biological activities such as anti-microbial, antitumor, anticancer, anti-fungicidal. [4][5][6][7][8][9] Numerous azo compounds are used in pharmaceuticals and cosmetics although some of them have been reported to be toxic. 1 Coordination compounds have also been investigated for the treatment of Alzheimer's disease (AD), Parkinson's dis-ease, aging, and those showing inhibitor activity of AChE promise in the use of therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

Ternary Transition Metal Complexes with an Azo-Imine Ligand and 2,2’-Bipyridine: Characterization, Computational Calculations, and Acetylcholinesterase Inhibition Activities

Serbest

Dural

Kızıl

et al. 2022

ACSi

View full text Add to dashboard Cite

New mononuclear ternary transition metal complexes: [M(HL)(bipy)2]ClO4, (M: Mn(II) for 1, Ni(II) for 2), [M(HL) (bipy) (ClO4)], (M: Ni(II) for 3, Cu(II) for 4, Zn(II) for 5) with M(II), 2-[(hydroxyimino)methyl]-4-[-phenyldiazenyl] phenol, H2L, and 2,2’-bipyridine were synthesized, and their structures were investigated by using various analytical, spectroscopic techniques such as elemental analysis, FTIR, UV-Vis, NMR, MALDI-TOF mass spectrometry, thermal analysis. The theoretical studies were performed by DFT techniques by using B3LYP function with 6-311++G (d, p)/ LanLD2Z basis set. The electronic transitions charters of the complexes were further analyzed by TD-DFT/CAM-B3LYP method. IR and thermal analysis data verify the proposed structures. The inhibition activities of the complexes against acetylcholinesterase (AChE) extracted from Ricania simulans adults and nymphs were examined and all the complexes were found to be active. Among the complexes studied, the highest inhibition activity was exhibited by complex 5 with the lowest IC50 value (3.2 ± 0.8 μM) for AChE of adults and complex 3 with the lowest IC50 value (4.6 ± 0.8 μM) for AChE of nymphs.

show abstract

Section: Introductionmentioning

confidence: 99%

Ternary Transition Metal Complexes with an Azo-Imine Ligand and 2,2’-Bipyridine: Characterization, Computational Calculations, and Acetylcholinesterase Inhibition Activities

Serbest

Dural

Kızıl

et al. 2022

ACSi

View full text Add to dashboard Cite

show abstract

“…Presently, several coordination complexes possessing antimicrobial activities are reported . The literature revealed an enhancement of antibacterial activity for metal complexes than their respective ligands . The prosthetic role of metals for metal complexes may be determined during their improved medicinal effects .…”

Section: Introductionmentioning

confidence: 99%

Aminothiazole-Linked Metal Chelates: Synthesis, Density Functional Theory, and Antimicrobial Studies with Antioxidant Correlations

Noreen

Sumrra

2021

ACS Omega

View full text Add to dashboard Cite

During the current study, the new aminothiazole Schiff base ligands (S 1 ) and (S 2 ) were designed by reacting 1,3thiazol-2-amine and 6-ethoxy-1,3-benzothiazole-2-amine separately with 3-methoxy-2-hydroxybenzaldehyde in good yields (68−73%). The ligands were characterized through various analytical, physical, and spectroscopic (FT-IR, UV−Vis, 1 H and 13 C NMR, and MS) methods. The ligands were exploited in lieu of chelation with bivalent metal (cobalt, nickel, copper, and zinc) chlorides in a 1:2 (M:L) ratio. The spectral (UV−Vis, FT-IR, and MS), as well as magnetic, results suggested their octahedral geometry. The theoretically optimized geometrical structures were examined using the M06/6-311G+(d,p) function of density function theory. Their bioactive nature was designated by global reactivity parameters containing a high hardness (η) value of 1.34 eV and a lower softness (σ) value of 0.37 eV. Different microbial species were verified for their potency (in vitro), revealing a strong action. The Gram-positive Micrococcus luteus and Gram-negative Escherichia coli gave the highest activities of 20 and 21 mm for compounds (8) and ( 7), respectively. The antifungal activity against the Aspergillus niger and Aspergillus terreus species gave the highest activities of 20 and 18 mm for compounds ( 7) and ( 6), respectively. The antioxidant activity, evaluated as DPPH and ferric reducing power, gave the highest inhibition (%) as 72.0 ± 0.11% (IC 50 = 144 ± 0.11 μL) and 66.3% (IC 50 = 132 ± 0.11 μL) for compounds (3) and (8), respectively. All metal complexes were found to be more biocompatible than free ligands due to their chelation phenomenon. The energies of LUMOs had a link with their activities. ■ HIGHLIGHTS• A facile synthesis of aminothiazole-containing Schiff bases and their metal chelates. • Combined experimental and theoretical exploration to decide their medicinal role. • Geometry optimization studies at the M06/6-311G +(d,p) level of density function theory. • The relative order of medicinal studies was as follows:reference drugs > metal chelates > ligands.

show abstract

“…In this aspect, nitrogen-containing systems are very promising class of compounds [4][5][6][7]. Triazole derivatives have long been included in world medical practice as highly active antibacterial, neuroleptic, antihypertensive and antispasmodic drugs [8,9]. Derivatives of 1,2,4triazole deserve special attention in this issue [10,11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antimicrobial and Antifungal Activity of Ylidenhydrazides of 2-((4-R-5-R1-4h-1,2,4-Triazol-3-Yl)thio)acetaldehydes

Shcherbyna¹,

Панасенко²,

Polonets³

et al. 2021

Ankara Universitesi Eczacilik Fakultesi Dergisi

View full text Add to dashboard Cite

Objective:The aim of this work is the synthesis and studying of antimicrobial and antifungal properties of the ylidenhydrazides of 2- ((4-R-5-R1-4H-1,2,4-triazol-3-yl)thio)acetaldehydes with the establishment of structure-activity relationships of the synthesized compounds.Material and Method: Determination of antimicrobial and antifungal activity was performed by discdiffusion method (DDM) on series of gram positive and gram negative bacteria such as Corynebacterium pseudodiphtheriticum, Pseudomonas aeruginosa, Enterococcus faecalis, Proteus vulgaris, Escherichia coli, Salmonella spp., Staphylococcus saprophyticus, Staphylococcus aureus, Streptococcus pyogenes, Candida.Result and Discussion: A new series of ylidenhydrazides of 2-((4-R-5-R1-4H-1,2,4-triazol-3yl)thio)acetaldehydes were synthesized and their structures were confirmed by modern methods of instrumental analysis: IR and 1 H-spectroscopy, elemental analysis and GS\MS method. For 13 compounds, the antimicrobial and antifungal activities were studied on 10 strains of microorganisms in 3 different concentrations (0.1; 0.2; 0.5%). According to the results of the study, some regularities of the structureactivity relationship have been established. The obtained results can serve as a basis for the targeted search compounds with pronounced antibacterial action. An increasing the concentration of tested compounds predictably lead to increase on antimicrobial activity in almost all cases. The most active compound in our study is N'-(2-((5-methyl-4H-1,2,4-triazol-3-yl)thio)ethylidene)-4-nitrobenzohydrazide 3i (ZOI for Sta.s. and Sp in 0.5% concentration is 25 and 26 mm, respectively).

show abstract

A review on the efficacy and medicinal applications of metal-based triazole derivatives

Cited by 45 publications

References 103 publications

Ternary Transition Metal Complexes with an Azo-Imine Ligand and 2,2’-Bipyridine: Characterization, Computational Calculations, and Acetylcholinesterase Inhibition Activities

Ternary Transition Metal Complexes with an Azo-Imine Ligand and 2,2’-Bipyridine: Characterization, Computational Calculations, and Acetylcholinesterase Inhibition Activities

Aminothiazole-Linked Metal Chelates: Synthesis, Density Functional Theory, and Antimicrobial Studies with Antioxidant Correlations

Synthesis, Antimicrobial and Antifungal Activity of Ylidenhydrazides of 2-((4-R-5-R1-4h-1,2,4-Triazol-3-Yl)thio)acetaldehydes

Contact Info

Product

Resources

About