“…The effectiveness of the quantity of extracted bioactive components depends on the culturing systems and productivity of dinoflagellate strains. For the optimization of growth conditions and toxin production of benthic dinoflagellate, various kinds of research have been conducted in different parts of the world (Dixon and Syrett, 1988;Kitaya et al, 2008;Morton et al, 1992;Nascimento et al, 2012;Pistocchi et al, 2011;Rhodes and Thomas, 1997;Tanimoto et al, 2013;Tosteson et al, 1989;Vidyarathna and Granéli, 2012;Yamaguchi et al, 2012;Zimmermann, 2006). However, most studies were only done for small-scale cultures.…”