A Review on the Drug Delivery Strategies for Parasitic Infections: Scope and Assertion

Abstract

Background: Parasitic infections are prime causes of morbidity and mortality worldwide. Significant progress has been made to cure these infections like discovery of antiparasitic drugs, developing new formulation strategies and site-directed drug delivery and chemotherapy etc. As synthetic drugs are perilous and have various side effects leading to the development of drug resistance and loss of health. Herbal medicines are economical and generally free from potential side effects is acclaiming recognition. However, it is difficult to produce antiparasitic vaccines, major efforts have been made and still there are no licensed vaccines currently available to control human parasitic ailments. Area covered: Here, a systematic review is dispensed assessing various techniques for the treatment of parasitic infections. Moreover, the advancements and challenges involved in establishing novel trends in the development of a more effective drug delivery systems are also investigated. Conclusion: The numbers of impending infectious ailments in humans have enhanced within the novel past or warn to increase in the future. Over thirty new infective agents have been identified globally in the last 30 years; approximately 60 % of these are from zoonotic sources. Efficient drug delivery plays a key role in treating parasitic infections. The main goal of modern antiparasitic drug delivery system is to minimize the potential side effects and bring the drug directly to the target pathogens, therefore, more sophisticated drug formulations than a simple tablet or solution are necessary for the betterment of critical situations of many human parasitic diseases.

Challenges and Prospective of Enhancing Hydatid Cyst Chemotherapy by Nanotechnology and the Future of Nanobiosensors for Diagnosis

“…There is potential for a significant improvement in clinical efficacy and bioavailability due to a revolution in medical technology [122]. Nano-based formulations of albendazole and mebendazole, two widely used anthelmintic drugs, have been found to have promising results in treating hydatid cyst disease [123][124][125].…”