A review on the diagnosis of feline infectious peritonitis

Yousuf, Jehanzeb; Bhat, Riyaz Ahmed; Dar, Sajad Hussain; Shafi, Alisa; Irshad, Snober; Yatoo, Mohd Iqbal; Parrah, Jalal Udin; Muhee, Amatul; Mir, Abdul Qayoom

doi:10.31893/avr.2022005

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…J. Yousuf et al [15] found that changes in indicators during biochemical blood tests in cats with FIP are variable and often non-specific, but there are several key abnormalities that doctors recommend considering before confirming the diagnosis. Thus, the above-mentioned authors indicate hyperglobulinaemia and hyperbilirubinemia.…”

Section: Literature Reviewmentioning

confidence: 99%

Morphological and biochemical changes in blood parameters in cats with infectious peritonitis

Melnyk¹,

Mickiewicz²,

MARTYNIUK³

et al. 2022

Ukrainian journal of veterinary sciences

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Feline infectious peritonitis is a feline disease, the causative agent of which is a mutant coronavirus, which leads to the death of young animals. Presently, this pathology is considered incurable, and therefore it requires a detailed study. The purpose of this study was to establish the features of clinical manifestation and haematological parameters in cats with infectious peritonitis. This paper presents the results of a clinical and laboratory study of 12 cats aged from 6 months to 3 years who were diagnosed with effusive and dry infectious peritonitis. Clinical, laboratory, and visual research methods were used. Laboratory analysis included a study of morphological and biochemical parameters of blood, cytological examination of effusion from the abdominal and pleural cavities, and a Rivalta test. As a result of cytological examination of effusion from these cavities, a high concentration of cells, macrophage accumulation, neutrophil phagocytosis, and red blood cells were detected in the entire field of view. It was found that the predictive value of the Rivalta test for feline infectious peritonitis is 62.5%. According to haematological examination, all sick animals were diagnosed with anaemia, lymphopenia, hypoalbuminemia, hyperglobulinemia, hyperbilirubinemia, increased activity of relative liver- specific enzymes (aspartate aminotransferase, alkaline phosphatase). Trobmocytopenia was observed in two animals, and an increase in blood markers of the functional state of the kidneys (creatinine, urea) was found in one cat. The serum albumin/globulin ratio should also be considered an important diagnostic indicator. Thus, with feline infectious peritonitis, this indicator should be < 0.4. In 11 sick cats, this ratio was characterized by values below 0.4, and in one animal this indicator was 0.46. In general, the obtained data of morphological and biochemical blood tests are not specific for feline infectious peritonitis, and therefore the authors of this paper recommend their comprehensive investigation for diagnostic purposes. An objective assessment of the available methods of laboratory diagnostics will contribute to the creation of a diagnostic protocol for feline infectious peritonitis

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Section: Literature Reviewmentioning

confidence: 99%

Morphological and biochemical changes in blood parameters in cats with infectious peritonitis

Melnyk¹,

Mickiewicz²,

MARTYNIUK³

et al. 2022

Ukrainian journal of veterinary sciences

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“…Hyperglobulinemia is observed in 89% of patients, and hypoalbuminemia or low-normal serum albumin level is observed in 64.5% of patients. A low albumin/globulin ratio (A/G) can be used to evaluate the diagnosis of FIP in patients with hyperglobulinemia and hypoalbuminemia [8]. FIP is difficult to diagnose because of non-specific clinical signs, non-pathognomonic hematological and biochemical abnormalities, and low sensitivity and specificity of tests used in the practical routine [9].…”

Section: Introductionmentioning

confidence: 99%

"An Initial Investigation into the Interrelation of Systemic Inflammatory Response Syndrome (SIRS), Feline Coronavirus (FCoV), and Neutrophil-Lymphocyte Ratio (NLR) in Cats"

Dokuzeylül,

İzmirli,

Telci

et al. 2023

Preprint

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Systemic inflammatory response syndrome (SIRS) is a clinical diagnosis based on abnormalities in patients' vital signs and white blood cell count. Neutrophil-lymphocyte ratio (NLR) is used as an easily accessible parameter to assess the patient's inflammatory status and stress. There are some studies showing that NLR affected by the inflammatory response is a criterion to support the diagnosis of SIRS. In this study, it was aimed to compare the interrelation between SIRS (+) and SIRS (-) groups in patients with high positive feline coronavirus (FCoV) in the light of NLR. Based on the anamneses, physical examination findings, laboratory findings, enzyme immunoassay antibody test kit titer were included in the sick groups. These patients were further categorized based on the presence of SIRS symptoms, vital signs and laboratory findings. The NLR as diagnostic marker demonstrated to differ between high antibody titer FCoV positive and healthy cats. However the diagnostic significance of NLR remains questionable between the high antibody titer FCoV positive cats with SIRS (+) and SIRS (-). As a result of our study NLR can be used as a blood parameter like albumin/globulin ratio and elevated total bilirubin in cats with high FCoV antibody titer and high probability of developing FIP.

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State of feline infectious peritonitis research in Ukraine during 2012-2022: systematic review

Murashko

2023

Nauk. vìsn. vet. med.

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The article analyzes scientific publications of Ukrainian researchers from 2012 to 2022. Thirtytwo scientific publications from open resources and available printed publications were included in the list of analyzed articles. The search for articles was carried out by specifying the keywords “infectious peritonitis” and “feline infectious peritonitis” in search engines and scientific databases Google Scholar, Directory of Open Access Journals (DOAJ), Web of Science (WoS), Scopus, as well as the search service of the National Library of Ukraine named after V.I. Vernadskyi. The main criteria for the selection of the articles were their thematic focus on the study of infectious peritonitis of cats and the availability of the text of publications in the Internet in open access. At the beginning, the article analyzes the disease, theoretical and practical interventions in the world practice of diagnosis and treatment of feline infectious peritonitis (FIP). The article contains description of the biological basis of the disease and complications development of cats with feline infectious peritonitis. The results of the analysis indicate that the majority of publications in Ukraine were devoted to the postmortem study of changes in the internal organs of cats that died from feline infectious peritonitis. The obtained results indicate the development of multiple organ failure in cats. Practical treatment results described the experience of 13 cats, 12 of which received injectable forms of GS-441524. According to the correlation analysis, the use of laboratory research methods was not polymodal in the diagnosis of infectious peritonitis in cats, as indicated by prevalence of low and medium correlation between the use of laboratory research methods. In general, the results of the study indicate that the state of research of FIP in Ukraine during 2012 - 2022 was ascertaining but not experimental. Key words: feline infectious peritonitis, effusive fluid, pathomorphological changes, Rivalta test, FIP diagnosis, FIP treatment, GS-441524.

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A review on the diagnosis of feline infectious peritonitis

Cited by 3 publications

References 26 publications

Morphological and biochemical changes in blood parameters in cats with infectious peritonitis

Morphological and biochemical changes in blood parameters in cats with infectious peritonitis

"An Initial Investigation into the Interrelation of Systemic Inflammatory Response Syndrome (SIRS), Feline Coronavirus (FCoV), and Neutrophil-Lymphocyte Ratio (NLR) in Cats"

State of feline infectious peritonitis research in Ukraine during 2012-2022: systematic review

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