A new type of Sm2Zr2O7 ceramic material has become a candidate material for thermal barrier coating because of its low thermal conductivity, high thermal expansion coefficient and good high temperature structure stability. In this paper, the effects of different process parameters on the morphology of ceramic powders were investigated. The spray drying technology was used to prepare Sm2Zr2O7 agglomerated powder. The micro morphology of Sm2Zr2O7 powder after granulation was observed by SEM. The effects of inlet temperature, pump creep rate on the characteristics of agglomerated powder were analyzed. At the same time, the effects of slurry properties on the micro characteristics of powder after granulation were discussed. The optimized Sm2Zr2O7 spray granulation process was determined as inlet temperature 175 ℃, pump creep rate 30% .