A review on the current progress of layered double hydroxide application in biomedical sectors

Karmakar, Aneek Krishna; Hasan, Md. Saif; Sreemani, Anirban; Jayanta, Anindya Das; Hasan, Md. Mehidi; Tithe, Nasrin Akter; Biswas, Prapti

doi:10.1140/epjp/s13360-022-02993-0

Cited by 5 publications

(2 citation statements)

References 425 publications

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“…[168] In addition, there are some reports on the pharmacokinetics and biocompatibility of LDH-based nanocomposites in mice, which laid the foundation for further clinical transformation. [169] It is worth mentioning that these LDH nanocomposites have been applied to tumor imaging and treatment, and can be used as effective carriers to deliver therapeutic drugs to mammalian cells. [170] These research results provide a solid foundation for the further application of LDH nanomaterials in the field of tumor imaging and treatment, and also pave the way for its future clinical transformation.…”

Section: Steps Towards Clinical Translation and Challengesmentioning

confidence: 99%

“…These evaluations cover animal cell lines and human cell lines, which provide important support for their future clinical application [168] . In addition, there are some reports on the pharmacokinetics and biocompatibility of LDH‐based nanocomposites in mice, which laid the foundation for further clinical transformation [169] . It is worth mentioning that these LDH nanocomposites have been applied to tumor imaging and treatment, and can be used as effective carriers to deliver therapeutic drugs to mammalian cells [170] .…”

Section: Steps Towards Clinical Translation and Challengesmentioning

confidence: 99%

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Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Ma,

Chen,

Qiao

2024

The Chemical Record

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Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist of orthorhombic arrays of metal hydroxides with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced drug bioavailability, LDHs have many potential applications in the medical field. Especially in the fields of bioimaging and tumor therapy. This paper reviews the research progress of LDHs and their nanocomposites in the field of tumor imaging and therapy. First, the structure and advantages of LDH are discussed. Then, several commonly used methods for the preparation of LDH are presented, including co‐precipitation, hydrothermal and ion exchange methods. Subsequently, recent advances in layered hydroxides and their nanocomposites for cancer imaging and therapy are highlighted. Finally, based on current research, we summaries the prospects and challenges of layered hydroxides and nanocomposites for cancer diagnosis and therapy.

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Section: Steps Towards Clinical Translation and Challengesmentioning

confidence: 99%