A Review on the Antioxidative and Prooxidative Properties of Luteolin

Xu, Haixia; Linn, Becky S; Zhang, Yingmei; Ren, Jun

doi:10.20455/ros.2019.833

Cited by 15 publications

(13 citation statements)

References 63 publications

(79 reference statements)

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“…Sangeetha (2019) reported the antioxidant activity of luteolin and demonstrated how this polymethoxyflavone protects the pancreas and promotes insulin secretion. In addition, luteolin suppressed oxidative damage, lipid peroxidation, and increased antioxidant enzymes such as CAT and SOD (Xu et al, 2019). Antioxidant properties of luteolin are also proved in the central nervous system (CNS).…”

Section: Luteolinmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Section: Luteolinmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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“…[26] Instead, the HA metabolite increased the flavonoids in the EVOOs. Luteolin has showed antitumorigenic, antimutagenic, antioxidative, immunomodulatory, and anti-inflammatory properties useful in cancer, cardiovascular diseases, and neurodegenerative pathologies prevention [27,28]. Finally, the 6PP metabolite improved lignans concentration in the EVOOs.…”

Section: Discussionmentioning

confidence: 99%

New Strategies in the Cultivation of Olive Trees and Repercussions on the Nutritional Value of the Extra Virgin Olive Oil

et al. 2020

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The health advantages of extra-virgin olive oil (EVOO) are ascribed mainly to the antioxidant ability of the phenolic compounds. Secoiridoids, hydroxytyrosol, tyrosol, phenolic acid, and flavones, are the main nutraceutical substances of EVOO. Applications of beneficial microbes and/or their metabolites impact the plant metabolome. In this study the effects of application of selected Trichoderma strains or their effectors (secondary metabolites) on the phenolic compounds content and antioxidant potential of the EVOOs have been evaluated. For this purpose, Trichoderma virens (strain GV41) and Trichoderma harzianum (strain T22), well-known biocontrol agents, and two their metabolites harzianic acid (HA) and 6-pentyl-α-pyrone (6PP) were been used to treat plants of Olea europaea var. Leccino and var. Carolea. Then the nutraceutical potential of EVOO was evaluated. Total phenolic content was estimated by Folin–Ciocalteau’s assay, metabolic profile by High-Resolution Mass spectroscopy (HRMS-Orbitrap), and antioxidant activity by DPPH and ABTS assays. Our results showed that in the cultivation of the olive tree, T22 and its metabolites improve the nutraceutical value of the EVOOs modulating the phenolic profile and improving antioxidants activity.

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“…ROS induce injuries to the mitochondrial respiratory chain and slow electron transfer through complex I, thereby causing a reduction in NADH [ 118 ]. Furthermore, mitochondria may potentiate ROS through ROS-induced ROS release, which involves ROS-induced activation of anion channels in the IMM, mPTP, and ATP-sensitive K + -channels [ 20 , 119 ]. Activation of these channels dissipates the ΔΨm and consumes NADH and NADPH, resulting in the emission of H 2 O 2 .…”

Section: Disruption Of Mitochondrial Ca 2+ Homeostmentioning

confidence: 99%

Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications

Cui

Zhang

et al. 2020

Acta Pharmacol Sin

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Heart failure (HF) represents one of the leading causes of cardiovascular diseases with high rates of hospitalization, morbidity and mortality worldwide. Ample evidence has consolidated a crucial role for mitochondrial injury in the progression of HF. It is well established that mitochondrial Ca 2+ participates in the regulation of a wide variety of biological processes, including oxidative phosphorylation, ATP synthesis, reactive oxygen species (ROS) generation, mitochondrial dynamics and mitophagy. Nonetheless, mitochondrial Ca 2+ overload stimulates mitochondrial permeability transition pore (mPTP) opening and mitochondrial swelling, resulting in mitochondrial injury, apoptosis, cardiac remodeling, and ultimately development of HF. Moreover, mitochondria possess a series of Ca 2+ transport influx and efflux channels, to buffer Ca 2+ in the cytoplasm. Interaction at mitochondria-associated endoplasmic reticulum membranes (MAMs) may also participate in the regulation of mitochondrial Ca 2+ homeostasis and plays an essential role in the progression of HF. Here, we provide an overview of regulation of mitochondrial Ca 2+ homeostasis in maintenance of cardiac function, in an effort to identify novel therapeutic strategies for the management of HF.

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A Review on the Antioxidative and Prooxidative Properties of Luteolin

Cited by 15 publications

References 63 publications

Citrus species: Modern functional food and nutraceutical-based product ingredient

Citrus species: Modern functional food and nutraceutical-based product ingredient

New Strategies in the Cultivation of Olive Trees and Repercussions on the Nutritional Value of the Extra Virgin Olive Oil

Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications

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