A review on target drug delivery: magnetic microspheres

Chandna, Amit; Batra, Deepa; Kakar, Satinder; Singh, Ramandeep

doi:10.1016/s2221-6189(13)60125-0

Cited by 36 publications

(25 citation statements)

References 22 publications

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“…[14] Magnetic carriers receive their magnetic responsiveness to a magnetic field from incorporated materials such as magnetite, iron, nickel, cobalt, neodymium-iron-boron or samarium cobalt. [15] Consequently, principle of magnetic drug targeting is shown in Figure 1. Therefore, the factors of magnetic field strength and geometry, which relate to magnet system are extremely important for designing the MTDDS.…”

Section: Drug Delivery and Targeting Systemsmentioning

confidence: 99%

Chitosan magnetic nanoparticles for drug delivery systems

Assa

Jafarizadeh‐Malmiri

Ajamein

et al. 2016

Critical Reviews in Biotechnology

150

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The potential of magnetic nanoparticles (MNPs) in drug delivery systems (DDSs) is mainly related to its magnetic core and surface coating. These coatings can eliminate or minimize their aggregation under physiological conditions. Also, they can provide functional groups for bioconjugation to anticancer drugs and/or targeted ligands. Chitosan, as a derivative of chitin, is an attractive natural biopolymer from renewable resources with the presence of reactive amino and hydroxyl functional groups in its structure. Chitosan nanoparticles (NPs), due to their huge surface to volume ratio as compared to the chitosan in its bulk form, have outstanding physico-chemical, antimicrobial and biological properties. These unique properties make chitosan NPs a promising biopolymer for the application of DDSs. In this review, the current state and challenges for the application magnetic chitosan NPs in drug delivery systems were investigated. The present review also revisits the limitations and commercial impediments to provide insight for future works.

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Section: Drug Delivery and Targeting Systemsmentioning

confidence: 99%

Chitosan magnetic nanoparticles for drug delivery systems

Assa

Jafarizadeh‐Malmiri

Ajamein

et al. 2016

Critical Reviews in Biotechnology

150

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“…In a novel drug delivery system, various route of administration may be used to achieve the controlled and targeted drug delivery [1]. A nasal cavity, as a site of drug delivery, have many advantages such as avoid first-pass metabolism, applicability for long-term treatment and because of the large surface area for absorption it may provide ease of administration.…”

Section: Introductionmentioning

confidence: 99%

Rizatriptan Benzoate Loaded Natural Polysaccharide Based Microspheres for Nasal Drug Delivery System

Sharma

2018

Int J App Pharm

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Objective: The objective of this research was to formulate and evaluate the different grades of rizatriptan benzoate loaded polysaccharide based microspheres for the nasal drug delivery system.Methods: The polysaccharide was extracted from the seed of Trigonella foenum-graecum and microspheres were prepared by emulsification, followed by crosslinking using epichlorohydrin. A 32 full factorial design was employed in formulating the microspheres with polymer concentration (X1), and stirring rate (X2) as independent variables and particle size (Y1) and entrapment efficiency (Y2) were dependent variables.Results: The microspheres were discrete and free-flowing. The mean particle size (Y1) of microspheres ranged from 40.82+12 µm to 62.48+0.41 µm and the encapsulation efficiency (Y2) was found to be increased from 60.7+0.2% to 79.22+0.2% as the drug polysaccharide ratio increased. A 32 full factorial design confirmed that the X1 and X2 both effect on particle size whereas X1 alone effect on entrapment efficiency. SEM revealed the smooth spherical surface of microspheres whereas kinetic model revealed that drug release followed the case II transport. FTIR indicated good compatibility of the excipients with rizatriptan benzoate. Stability studies were carried out for formulation F7 at 4°C ambient, 25+2°C/60+5%, 40+2°C/75+5% relative humidity revealed that the physical drug appearance, entrapment efficiency were within the permissible limits.Conclusion: The result obtained in this research work indicate a promising potential of control release rizatriptan benzoate loaded microspheres whereas the Trigonella foenum-graecum polysaccharide used as rate controlling polymer for the effective treatment of migraine patients.

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“…In addition, the soft lipophilic silicone matrix introduces new possibilities for encapsulation and delivery of poorly-soluble non-polar drug species. There have been many reports of microsphere formulations of hydrophilic matrices for drug delivery applications [39–41], yet relatively few reports of hydrophobic matrices and even fewer which include magnetic nanoparticles in hydrophobic matrices for stimulated release or targeting [42–46]. …”

Section: Introductionmentioning

confidence: 99%

High-permeability functionalized silicone magnetic microspheres with low autofluorescence for biomedical applications

Evans

Ronecker

Han

et al. 2016

Materials Science and Engineering: C

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Functionalized magnetic microspheres are widely used for cell separations, isolation of proteins and other biomolecules, in vitro diagnostics, tissue engineering, and microscale force spectroscopy. We present here the synthesis and characterization of a silicone magnetic microsphere which can be produced in diameters ranging from 0.5 to 50 μm via emulsion polymerization of a silicone ferrofluid precursor. This bottom-up approach to synthesis ensures a uniform magnetic concentration across all sizes, leading to significant advances in magnetic force generation. We demonstrate that in a size range of 5–20 μm, these spheres supply a full order of magnitude greater magnetic force than leading commercial products. In addition, the unique silicone matrix exhibits autofluorescence two orders of magnitude lower than polystyrene microspheres. Finally, we demonstrate the ability to chemically functionalize our silicone microspheres using a standard EDC reaction, and show that our folate-functionalized silicone microspheres specifically bind to targeted HeLa and Jurkat cells. These spheres show tremendous potential for replacing magnetic polystyrene spheres in applications which require either large magnetic forces or minimal autofluorescence, since they represent order-of-magnitude improvements in each. In addition, the unique silicone matrix and proven biocompatibility suggest that they may be useful for encapsulation and targeted delivery of lipophilic pharmaceuticals.

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A review on target drug delivery: magnetic microspheres

Cited by 36 publications

References 22 publications

Chitosan magnetic nanoparticles for drug delivery systems

Chitosan magnetic nanoparticles for drug delivery systems

Rizatriptan Benzoate Loaded Natural Polysaccharide Based Microspheres for Nasal Drug Delivery System

High-permeability functionalized silicone magnetic microspheres with low autofluorescence for biomedical applications

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