A Review on Synthetic Protocols of Pyridazine and Pyridazone Analogues

Jakhmola, Vikash; Jawla, Sunil; Tangri, Prianshu; Mishra, Ravinesh

doi:10.35652/igjps.2016.03

Cited by 1 publication

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References 21 publications

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“…In recent years substituted pyridazinones have been a subject of demanding research due to their wide range of pharmacological actions 22,24 . Differently substituted pyridazinone derivatives were exhibited diverse potential pharmacological activities like an antidepressant, antihypertensive, anti-thrombotic, anticonvulsant, cardiotonic, analgesic, antiinflammatory, diuretics, antibacterial, anti-fungal, antiviral, anticancer, hypotensive, antiulcer and another biological activities 25,29 . (2H)-one (0.001 mol) in methanol (30 mL) was added formaldehyde (37-41%) (2.5 mL) and the contents were refluxed for 6 h. After completion of the reaction methanol was distilled off and the residue was poured into crushed ice to separate out the compound.…”

Section: Methodsmentioning

confidence: 99%

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The main objective presents research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives. To study the different synthesized derivatives by using different analytical parameters like IR, Mass, and NMR analysis. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wide activity spectrum on the cardiovascular system. Pyridazine derivatives, a class of compounds containing the N-N bond, exhibit a wide range of pharmacological activities such as antidepressant, antihypertensive and cardiotonic etc. Some 7-phenyl-3, 4, 8, 9-tetrahydro-2H-pyridazino [1, 6-a] [1, 3, 5] triazin-2-imine were synthesized by reacting 6-Phenyl substituted 2, 3, 4, 5-Tetrahydro pyridazin-3-one with cyclic secondary amine under Mannich reaction conditions. The total seven compounds (vj1-vj7) were synthesized under Mannich reaction conditions. All the synthesized derivatives were selected for evaluation of antihypertensive activities by a noninvasive method using Tail Cuff method. Most of the compounds showed good antihypertensive activity. Few compounds like vj4, vj5, and vj6 were found to show a highly significant reduction in mean arterial blood pressure but at a higher dose in comparison to standard drugs like proponolol and hydralazine. The substituted pyridazine derivatives discovered in this study may provide valuable therapeutic intervention for the treatment of hypertension. INTRODUCTION:In the present scenario, a large number of medications acting through different mechanisms for the treatment of hypertension are available.

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Section: Methodsmentioning

confidence: 99%

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2022

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A Review on Synthetic Protocols of Pyridazine and Pyridazone Analogues

Cited by 1 publication

References 21 publications

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