A Review on Synthesis and Pharmacological Activities of Piracetam and its Derivatives

Abstract

Piracetam is generally utilized as a nootropic drug, which is normally used in the treatment of CNS disorders. Piracetam is a cyclic compound and a derivative of γ-aminobutyric acid and improves learning, memory, brain metabolism, and ability. This drug belongs to the racetams group with the chemical name 2-oxo-1-pyrrolidine acetamide. The emphasis of this review article is to highlight different biological activities associated with piracetam and also some of its synthetic methodologies. Promising effects have been achieved in the management and treatment of several diseases for example alcoholism, Raynaud’s phenomenon, deep vein thrombosis and brain injury.

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“…Nootropics are the compounds used to enhance the capacity of work and performance of the brain the drugs. The researchers revealed the anti-epileptic activity of the nootropics compounds belonging to γ-aminobutyric acid (GABA) derivative, piracetam analog like rolziracetam, oxiracetam, etiracetam and nefiracetam 2 . Anticonvulsant activity of carbazole and its derivatives was dertermined 3 .…”