A review on structural genomics approach applied for drug discovery against three vector-borne viral diseases: Dengue, Chikungunya and Zika

Sundar, Shobana; Shanmughavel, P.; Natarajan, Jeyakumar

doi:10.1007/s11262-022-01898-5

Cited by 6 publications

(1 citation statement)

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“…Dengue virus belongs to the genus flavivirus of the Flaviviridae family (Murugesan and Manoharan, 2020). The genome encodes three structural proteins which are the capsid (C), envelope (E) and membrane (M) proteins and seven non-structural proteins which are NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 by the host proteases (Furin and signalase) and the two-component viral NS2B-NS3 protease (Sundar et al, 2022). The DENV NS2B-NS3 pro (serine protease), which belongs to the trypsin superfamily, contains a catalytic triad in its active site formed by His51, Asp75 and Ser135 residues (Li et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Comparative screening of anti-dengue activity in aqueous and ethanol extracts of mangrove plants from Sabah

Misrah, M. F.,

Yusof, N. A.,

Amin, Z.

et al. 2023

MJM

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Aims: Dengue virus is a global pathogen that lacks an effective vaccine or therapy. Screening medicinal plants for antidengue properties provides a promising avenue to identify potent compounds. Mangroves, known for their resilience in harsh conditions, produce a diverse range of natural products with unique biochemical profiles, which hold potential for anti-dengue treatments. This study aims to evaluate the anti-dengue activity of selected mangrove plant species from Sabah against DENV2 NS2B-NS3pro, utilizing an enzymatic protease assay. Methodology and results: Six mangrove species (Avicennia marina, Bruguiera gymnorrhiza, Ceriops tagal, Rhizophora apiculata, Rhizophora mucronata and Xylocarpus granatum) were investigated, with various plant parts subjected to aqueous and ethanol extraction. The results demonstrated significant anti-dengue activity in both aqueous and ethanolic extracts of the mangroves against DENV2 NS2B-NS3pro, with IC50 values ranging from 0.95 µg/mL to 6.24 µg/mL. Notably, the ethanolic extract of R. apiculata leaves exhibited the highest inhibition, with an IC50 value of 0.95 µg/mL. Conclusion, significance and impact of study: These findings suggest that the ethanolic extracts from R. apiculata leaves hold promise as potential candidates for dengue treatment. This study underscores the importance of natural products as valuable sources for the development of novel anti-dengue treatments, highlighting the need to explore mangroves in the quest for effective therapeutic options.

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Section: Introductionmentioning

confidence: 99%