A Review on Severe Acute Respiratory Syndrome 2 (SARS COV-2)

Rasheed, Arsalan; Usman, Τahir; Niaz, Sadaf; Khattak, Irfan; Gul, Saira; Ali, Niaz; Khan, Noor; Ali, Hazrat; Sarwar, Mian Saeed

doi:10.17582/journal.pjz/20210107160135

Cited by 2 publications

(4 citation statements)

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“…Because of SARS-CoV-2, 162,628,327 people got infected, and 3,373,813 people died fighting against it 5 . So, there is a need to search for an effective and efficient cure for COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Drugs being tested against covid-19 to slow down its spread and find effective treatment: A systematic review.

Rasheed

Νοοr

Usman

et al. 2022

Int. j. endorsing health sci. res.

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Background: The SARS-COV-2's spread from continent to the continent has resulted in an increased number of mutations in the viral gene encoding proteins. As a result, mutations in target proteins provide a significant challenge in creating antiviral drugs and vaccines. The present review discussed the COVID-19 epidemiology and the effects of drugs being tested against COVID-19/SARS-COV-2. Dosage of these drugs along with associated challenges was also discussed. Methodology: Systematic review was conducted after a thorough search in the "PubMed, NIH, Elsevier, Scopus, Web of Science, Science Direct, and Google Scholar database. 45 studies on drugs associated with COVID-19 fulfilled the inclusion criteria and were selected for this review. Results: The FDA only accepted the Remdesivir drug against SARS-COV-2, as the hospitalized patients recovered very quickly by taking it. Antiviral EIDD-2801 has been found to make the SARS-COV-2 unable to infect cells by causing genetic modifications in the virus RNA. Similarly, Nitazoxanide appeared beneficial against SARS-COV-2 in a primary intervention and severe conditions (including pregnancy) without undesirable effects on the newborns. Children with mild cases can be handled solely by proper caring. Conclusion: Although Remdesivir and Dexamethasone are recommended in severe cases, clinical trials are ongoing to investigate other possible therapies like MAb and Convalescent Plasma antibodies for COVID-19. Older drugs (usually used to treat other conditions) are also under-tested by researchers to see if they are effective for COVID-19. Further tests are essential to validate whether any of the mentioned above possible therapies would be helpful for COVID-19 treatment.

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“…Because of SARS-CoV-2, 162,628,327 people got infected, and 3,373,813 people died fighting against it 5 . So, there is a need to search for an effective and efficient cure for COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Drugs being tested against covid-19 to slow down its spread and find effective treatment: A systematic review.

Rasheed

Νοοr

Usman

et al. 2022

Int. j. endorsing health sci. res.

Self Cite

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“…Each year for saving millions of lives from communicable diseases, vaccination remains one of the most reliable and highly cost-effective public health interventions. [1,7]. The development of COVID-19 vaccines was aided by the knowledge about coronavirus causing SARS Vaccines are widely recognized by health authorities and the medical community as a major tool for achieving public health successes, such as the eradication of smallpox [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…COVID-19 was discovered in Wuhan, China, in December 2019 [ 1 ]. COVID-19 has had a great impact on developing countries surrounding China, including Pakistan, India, Iran, Afghanistan, and Bangladesh [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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An Insight Into the Acceptance and Hesitancy of COVID-19 Vaccines in Pakistan: A Cross-Sectional Survey

Rasheed¹,

Idrees²,

Khan³

et al. 2022

Cureus

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Background: COVID-19 vaccines are found to be effective interventions to tackle COVID-19. However, the hesitancy towards its acceptance has been rising in Pakistan. This study highlights the opinion of the general population in Pakistan regarding the acceptance and hesitancy of COVID-19 vaccination.Methods: A descriptive cross-sectional survey study was conducted among Pakistanis from December 2021 to January 2022. Adult respondents that have and have not received COVID-19 vaccinations were included in this study. Data collection was obtained through questionnaires that assessed acceptance and hesitancy toward COVID-19 vaccines. Statistical analysis was performed using IBM SPSS software version 25 for Windows.Results: We obtained 367 respondents with 333 respondents completing the questionnaire. There were 259 respondents who have been vaccinated. A total of 67.9% of responses agreed that vaccines could control the COVID-19 pandemic. The reasons for not getting vaccination were afraid of adverse effects (48.6%) and COVID-19 vaccines not being tested thoroughly (30.9%). The main reason for vaccine acceptance was awareness about vaccines (23.1%), a belief that vaccines can stop severe COVID-19 disease (16.8%), and self-protection (14.7%).Conclusion: Most Pakistanis agreed that vaccines could manage the pandemic. Vaccine acceptance was contributed by the awareness and belief regarding the protective effects of vaccines while vaccine hesitancy was due to the public's doubt about the vaccines' side effects and testing. The Pakistan government should focus on emphasizing knowledge about vaccines, educating the vaccines' adverse effects, and utilizing social media in doing so.

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A Review on Severe Acute Respiratory Syndrome 2 (SARS COV-2)

Abstract: Authors' Contribution AR, SN, SG, HA, MSS and NUK collected and analysed the data, drafted and co-wrote the manuscript. TU, NA and IK designed the work, co-wrote the manuscript, revised the manuscript and gave final approval of the version to be published.

Cited by 2 publications

References 21 publications

Drugs being tested against covid-19 to slow down its spread and find effective treatment: A systematic review.

Drugs being tested against covid-19 to slow down its spread and find effective treatment: A systematic review.

An Insight Into the Acceptance and Hesitancy of COVID-19 Vaccines in Pakistan: A Cross-Sectional Survey

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