A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study

Ahda, Mustofa; Jaswir, Irwandi; Khatib, Alfi; Ahmed, Qamar Uddin; Mahfudh, Nurkhasanah; Ardini, Yunita Dewi

doi:10.1080/10942912.2023.2215475

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…Currently available synthetic anti-diabetic interventions for type 2 diabetes such as biguanides, sulfonylureas, thiazolidinediones, α-glucosidase inhibitors, glucagon-like peptide-1 (GLP-1), and dopamine-2 agonists, dipeptidyl peptidase 4 (DPP-4), and sodium-glucose cotransporter-2 (SGLT 2) have been alluded to cause side effects including cancer, hepatitis, allergy, among others following prolonged consumption [23] [24]. Medicinal products developed from naturally occurring bioactive compounds are mused to be less toxic compared to synthetic drugs thus the growing consideration for their utilization as promising interventions for the management of various disease conditions including diabetes [25].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Properties of <i>Bidens pilosa</i> and Its Polyacetylenic Compounds for Management of Diabetes: Systematic Review

Waititu,

Mugo,

Nyawira

et al. 2024

JBM

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Bidens pilosa is a member of the Asteraceae family that is widely distributed across the tropics. It has been utilized by different communities both as food and medicinal herb. This plant and its polyacetylenic compounds hold potential as a natural antidiabetic intervention that can be used to combat this global public health problem. Bioactive compounds found in this plant constitute promising interventions for combating obesity which is a major risk factor for the development of type 2 diabetes. These phytocompounds can work independently or synergistically to modulate appetite, lipase activity, adipogenesis and adipocyte apoptosis. However, the efficacy, mode of action and scope of management of diabetes by these compounds remains elusive. The current review aims to summarize data on efficacy in the management of diabetes, an antidiabetic candidate polyacetylenic compound and possible biological activities as an antidiabetic agent from the available literature. Much emphasis has been directed to cytopiloyne as a representative of polyacetylenic compounds extracted from Bidens pilosa and its activity on diabetic animal models. The majority of the studies conducted on animal models described antidiabetic mechanisms that range from hypoglycemic to secretagogue activity of cytopiloyne in a dose-dependent manner. A clinical trial pilot indicated improved glycemic control of Bidens pilosa formulation among diabetic patients in the study. Bidens pilosa and its compounds are highly potent antidiabetic agent(s) that should be graduated to an intervention for management of diabetes through pre-clinical and clinical trials to elucidate its efficacy and safety.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic Properties of <i>Bidens pilosa</i> and Its Polyacetylenic Compounds for Management of Diabetes: Systematic Review

Waititu,

Mugo,

Nyawira

et al. 2024

JBM

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“…The leaves contain flavonoids and their derivatives, including sinensetin, which exhibit disease-prevention properties 3 , 4 . According to Ahda et al 5 , this plant has various mechanisms of action to lower blood glucose levels, including boosting GLP-1 secretion and blocking α-glucosidase and α-amylase. Additionally, a nuvastatic supplement made from standardized O. stamineus extract for administration in diabetic retinopathy (DR) patients in clinical research has been registered (registration number NCT04552600).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis, antioxidant, α-glucosidase inhibitory activity, and toxicity evaluation of Orthosiphon stamineus leaf extract

Ahda,

Jaswir,

Khatib

et al. 2023

Sci Rep

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Ocimum aristatum, commonly known as O. stamineus, has been widely studied for its potential as an herbal medicine candidate. This research aims to compare the efficacy of water and 100% ethanolic extracts of O. stamineus as α-glucosidase inhibitors and antioxidants, as well as toxicity against zebrafish embryos. Based on the study findings, water extract of O. stamineus leaves exhibited superior inhibition activity against α-glucosidase, ABTS, and DPPH, with IC50 values of approximately 43.623 ± 0.039 µg/mL, 27.556 ± 0.125 µg/mL, and 95.047 ± 1.587 µg/mL, respectively. The major active compounds identified in the extract include fatty acid groups and their derivates such as linoleic acid, α-eleostearic acid, stearic acid, oleanolic acid, and corchorifatty acid F. Phenolic groups such as caffeic acid, rosmarinic acid, 3,4-Dihydroxybenzaldehyde, norfenefrine, caftaric acid, and 2-hydroxyphenylalanine and flavonoids and their derivates including 5,7-Dihydroxychromone, 5,7-Dihydroxy-2,6-dimethyl-4H-chromen-4-one, eupatorin, and others were also identified in the extract. Carboxylic acid groups and triterpenoids such as azelaic acid and asiatic acid were also present. This study found that the water extract of O. stamineus is non-toxic to zebrafish embryos and does not affect the development of zebrafish larvae at concentrations lower than 500 µg/mL. These findings highlight the potential of the water extract of O. stamineus as a valuable herbal medicine candidate, particularly for its potent α-glucosidase inhibition and antioxidant properties, and affirm its safety in zebrafish embryos at tested concentrations.

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Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara

Wang,

Yu,

Zhang

et al. 2024

J Nat Med

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A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study

Cited by 3 publications

References 42 publications

Antidiabetic Properties of <i>Bidens pilosa</i> and Its Polyacetylenic Compounds for Management of Diabetes: Systematic Review

Antidiabetic Properties of <i>Bidens pilosa</i> and Its Polyacetylenic Compounds for Management of Diabetes: Systematic Review

Phytochemical analysis, antioxidant, α-glucosidase inhibitory activity, and toxicity evaluation of Orthosiphon stamineus leaf extract

Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara

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A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study

Cited by 3 publications

References 42 publications

Antidiabetic Properties of &lt;i&gt;Bidens pilosa&lt;/i&gt; and Its Polyacetylenic Compounds for Management of Diabetes: Systematic Review

Antidiabetic Properties of &lt;i&gt;Bidens pilosa&lt;/i&gt; and Its Polyacetylenic Compounds for Management of Diabetes: Systematic Review

Phytochemical analysis, antioxidant, α-glucosidase inhibitory activity, and toxicity evaluation of Orthosiphon stamineus leaf extract

Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara

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Product

Resources

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Antidiabetic Properties of <i>Bidens pilosa</i> and Its Polyacetylenic Compounds for Management of Diabetes: Systematic Review

Antidiabetic Properties of <i>Bidens pilosa</i> and Its Polyacetylenic Compounds for Management of Diabetes: Systematic Review