A review on scope of immuno-modulatory drugs in Ayurveda for prevention and treatment of Covid-19

Niraj, Srivastava; Saxena, Varsha

doi:10.14719/pst.2020.7.3.831

Cited by 24 publications

(17 citation statements)

References 37 publications

(38 reference statements)

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“…Withania somnifera , a key plant of Ayurveda, contains compounds inhibiting M pro and S protein, ( Chikhale et al, 2020 ; Tripathi et al, 2020 ) and the extract of the plant provides anti-viral immunity by increasing interferon gamma responses and anti-inflammatory activities by decreasing the quantity of interleukin-1, interleukin-6 and Tumor necrosis factor related to COVID-19 ( Niraj and Varsha, 2020 ).…”

Section: Drug Search Strategies In Phytomedicinementioning

confidence: 99%

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In Search of Herbal Anti-SARS-Cov2 Compounds

2020

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On March 11, 2020, the World Health Organization (WHO) announced that the spread of the new coronavirus had reached the stage of a pandemic. To date (23.10.2020), there are more than 40 million confirmed cases of the disease in the world, at the same time there is still no effective treatment for the disease. For management and treatment of SARS-Cov2, the development of an antiviral drug is needed. Since the representatives of all human cultures have used medicinal plants to treat viral diseases throughout their history, plants can be considered as sources of new antiviral drug compounds against emerging viruses. The huge metabolic potential of plants allows us to expect discovery of plant compounds for the prevention and treatment of coronavirus infection. This idea is supported by number of papers on the anti-SARS-Cov2 activity of plant extracts and specific compounds in the experiments in silico , in vitro , and in vivo . Here, we summarize information on methods and approaches aimed to search for anti-SARS-Cov2 compounds including cheminformatics, bioinformatics, genetic engineering of viral targets, interacting with drugs, biochemical approaches etc. Our mini-review may be useful for better planning future experiments (including rapid methods for screening compounds for antiviral activity, the initial assessment of the antiviral potential of various plant species in relation to certain pathogens, etc.) and giving a hand to those who are making first steps in this field.

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Section: Drug Search Strategies In Phytomedicinementioning

confidence: 99%

“…Tinosponone from Tinospora cordifolia inhibits M pro ( Krupanidhi et al, 2020 ), and the aqueous extracts of the plant affects the cytokine production and activation of immune effector cells ( Niraj and Varsha, 2020 ).…”

Section: Drug Search Strategies In Phytomedicinementioning

confidence: 99%

In Search of Herbal Anti-SARS-Cov2 Compounds

2020

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“…Later the structures of phytochemicals were converted into PDB format with the help of graphic user interface “Open Babel GUI” (http://openbabel.org/wiki/Main_Page) [36] . We have performed molecular docking with Aristololactum, Fargesin, I-Asarinin, Lignans Machilin F, Piperundecalidine and Pluviatilol.…”

Section: Methodsmentioning

confidence: 99%

In silico investigation of phytoconstituents of medicinal herb ‘Piper Longum’ against SARS-CoV-2 by molecular docking and molecular dynamics analysis

Lakhera

Devlal

Ghosh

et al. 2021

Results in Chemistry

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“…As a result, the frame that individuals use to understand and address COVID-19 shifts according to the cultural reasoning style and associated medical model. To illustrate, while also supporting vaccinations, Ayurvedic doctors and researchers have examined COVID-19 in terms of how the disease functions within the larger weakened system, proposing that treatment should focus on ensuring that global bodily functions are supported while strengthening immune and respiratory systems to prevent infection, and to ease the course of the disease should one contract the virus (Niraj and Varsha, 2020 ; Rajkumar, 2020 ; Rastogi et al, 2020 ).…”

Section: Cross-societal Differences: Cultural Values and Relational Mobilitymentioning

confidence: 99%

The Social Lives of Infectious Diseases: Why Culture Matters to COVID-19

2021

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Over the course of the year 2020, the global scientific community dedicated considerable effort to understanding COVID-19. In this review, we discuss some of the findings accumulated between the onset of the pandemic and the end of 2020, and argue that although COVID-19 is clearly a biological disease tied to a specific virus, the culture–mind relation at the heart of cultural psychology is nonetheless essential to understanding the pandemic. Striking differences have been observed in terms of relative mortality, transmission rates, behavioral responses, official policies, compliance with authorities, and even the extent to which beliefs about COVID-19 have been politicized across different societies and groups. Moreover, many minority groups have very different experiences of the pandemic relative to dominant groups, notably through existing health inequities as well as discrimination and marginalization, which we believe calls for a better integration of political and socioeconomic factors into cultural psychology and into the narrative of health and illness in psychological science more broadly. Finally, individual differences in, for example, intolerance of uncertainty, optimism, conspiratorial thinking, or collectivist orientation are influenced by cultural context, with implications for behaviors that are relevant to the spread and impact of COVID-19, such as mask-wearing and social distancing. The interplay between cultural context and the experience and expression of mental disorders continues to be documented by cultural-clinical psychology; the current work extends this thinking to infectious disease, with special attention to diseases spread by social contact and fought at least in part through social interventions. We will discuss cultural influences on the transmission, course, and outcome of COVID-19 at three levels: (1) cross-society differences; (2) within-society communities and intergroup relations; and (3) individual differences shaped by cultural context. We conclude by considering potential theoretical implications of this perspective on infectious disease for cultural psychology and related disciplines, as well as practical implications of this perspective on science communication and public health interventions.

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A review on scope of immuno-modulatory drugs in Ayurveda for prevention and treatment of Covid-19

Cited by 24 publications

References 37 publications

In Search of Herbal Anti-SARS-Cov2 Compounds

In Search of Herbal Anti-SARS-Cov2 Compounds

In silico investigation of phytoconstituents of medicinal herb ‘Piper Longum’ against SARS-CoV-2 by molecular docking and molecular dynamics analysis

The Social Lives of Infectious Diseases: Why Culture Matters to COVID-19

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