A review on role of psychological factors in the etiopathogenesis of Pandu Roga with reference to iron deficiency anemia

Rai, Shalini; Kar, Anukul Chandra

doi:10.4103/ayu.ayu_186_13

Cited by 5 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the presence of urea, the exothermic peak of OBSH/urea sample changes to 135.87°C, and the exothermic heat of OBSH/urea is 169.4 J g −1 . The endothermic peak appearing before the exothermic peak of OBSH/urea is corresponding to the fusion of urea, which resulted in the decrease of the overall exothermic heat of the OBSH/urea system.…”

Section: Resultsmentioning

confidence: 99%

Urea‐activated 4,4'‐oxibis‐(benzenesulfonyl hydrazide) as foaming agent for low‐density unsaturated polyester resin manufacturing

Zhang

Wang

Pan

et al. 2015

J of Applied Polymer Sci

View full text Add to dashboard Cite

The activation of foaming agent is critical to its application. In this study, 4,4 0 -oxibis-(benzenesulfonyl hydrazide) (OBSH) activated by urea was used in the manufacture of low-density unsaturated polyester resin (LDUPR), and the results were compared with that of OBSH activated by zinc oxide and zinc stearate. The experiment results showed that the activation of OBSH by urea was better than by zinc oxide or by zinc stearate. A novel hydrogen bond activation mechanism of urea is presented in this research. Two stages, including the induction stage and the foaming stage, were proposed in the LDUPR manufacture according to the gas evolution curves of activated OBSH. The decomposition temperature and the decomposition time of OBSH activated by urea were determined to match the gelation time of UPR for the manufacture of LDUPR. The disadvantageous chemical behaviors of activated OBSH were eliminated in the induction treatment. The activated OBSH via induction treatment released gas maximally and distributed gas homogeneously in the resin glue, resulting in a better foaming effect than that of the previous foaming agents.

show abstract

Section: Resultsmentioning

confidence: 99%

Urea‐activated 4,4'‐oxibis‐(benzenesulfonyl hydrazide) as foaming agent for low‐density unsaturated polyester resin manufacturing

Zhang

Wang

Pan

et al. 2015

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…IDA is correlated with Pandurog, which is described as a Rasa Pradoshaja Vikara, wherein Alpa Rakta (decreased blood) is one of the key features along with Panduta (paleness) [ 21 ]. Abhraloha is a Rasayana formulation that supports the function of Agni (metabolism) to produce quality Aahara Rasa (nutrition) that subsequently results in enhanced formation of Rakta Dhatu (blood tissue) while maintaining the Dosha balance (functional balance of Tri-Dosha elements) in the body.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of the Efficacy, Safety, and Tolerability of Abhraloha Compared With Oral Ferrous Ascorbate on Iron Deficiency Anemia in Women: A Randomized Controlled, Parallel-Group, Assessor-Blind Clinical Trial

Gajbhiye

Koli

Harit

et al. 2021

Cureus

View full text Add to dashboard Cite

Background and objective Iron deficiency anemia (IDA) is a common condition in women for which ferrous ascorbate (FA) is often prescribed, which can lead to multiple side effects. Abhraloha is an Ayurvedic medicine that has been used for decades in India to treat IDA. In this study, we aimed to evaluate the efficacy and safety of Abhraloha with regard to change in hemoglobin (Hb) levels as compared to the standard treatment using FA in participants with IDA. Materials and methods We conducted a single-center, pragmatic, prospective, randomized, active-controlled, two-arm, parallel-group, assessor-blind study to evaluate the efficacy and safety of Abhraloha with regard to change in Hb levels as compared to the standard treatment using FA in participants suffering from IDA. The eligible participants were randomized and were advised to take either Abhraloha (two tablets twice a day) or FA (one tablet twice a day) for eight weeks; they were asked to follow up after 14 days for re-evaluation. On visit 1 and during the study period, the physician assessed the participants on the Pandurog scale and subjective variables. Descriptive statistics were used with unpaired T-test/Mann-Whitney U test for comparison between the groups. The Wilcoxon signed-rank test was used for within-group analysis, and the chi-square test/Fisher’s exact test was employed for categorical data. Results Based on our findings, Abhraloha tablets significantly increased all the variables including the Pandurog scale after eight weeks of treatment. Abhraloha reduced total iron-binding capacity (TIBC) and peripheral smear lymphocyte (PSL), which is consistent with an improvement in IDA. There was a statistically significant increase in Hb, red blood cell (RBC) count, packed cell volume (PCV), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) in the Abhraloha group as compared with the FA group at eight weeks. The Abhraloha group also exhibited a statistically significant improvement in all the subjective variables. Abhraloha was found to be safe and well-tolerated among the participants. Conclusions Abhraloha possesses hematinic activity and it improves all the blood indices. It is associated with significantly fewer adverse effects compared to oral iron therapy, which proves that it can be safely used for the treatment of IDA.

show abstract

“…The National policy prescribes routine oral IS for at least 3 months during pregnancy, given the high prevalence among pregnant women in India. However, a majority of pregnant women probably do not complete the treatment due to the side effects of IS and almost 35% of them could be noncompliant 8,15,16 .…”

Section: Major Reasons For Persistence Of Anaemia As a Public Health ...mentioning

confidence: 99%

“…Udipi SA, Joshi J, Singh G, Sawarkar S, Phadke A, Prabhu A, Rastogi N and Vaidya AB: Phytoactives as chelators of iron with potential to mitigate its side effects and enhance iron absorption. Int J Pharm Sci & Res 2022; 13(8): 3078-02. doi: 10.13040/IJPSR.0975-8232.13 (8).3078-02.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

“…IDA is considered as one of the most expensive diseases due to lost productivity, and the large numbers affected; 4, 7 its effect on overall health and earning potential at family level, productivity and impact on the economy at community and country level. Since the consequences of anaemia for an individual and an entire country can be devastating, prevention and control of anaemia by 2025 is one of the global targets 6,7,8,9 . IDA results from not only Fe deficiency but also from haemorrhagic blood loss or diarrhoeas Fig.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2022

IJPSR

View full text Add to dashboard Cite

Iron deficiency anaemia afflicts a large proportion of the human population, compromising productivity and quality of life. Iron supplements are widely prescribed for treating anaemia. However, poor compliance due to side effects, particularly gastrointestinal side effects, remain a hurdle in alleviating the problem, leading to unabated high prevalence. Thus, a fresh look at novel approaches to supplementation is essential. Iron toxicity is attributed to the Fenton Reaction and generation of reactive oxygen species leading to oxidative stress. Several studies suggest that the FR and ROS caused by excess iron, results in chronic inflammation, leading to metabolic syndrome, diabetes mellitus, atherosclerosis, cancer, neurodegenerative disorders. Iron chelates have been developed as treatment modalities to reduce free radical generation, reduce GI side effects, and enhance absorption. Classical Fe chelators, developed to counteract iron overload/ toxicity, cannot be used in IDA, due to severe side effects. In Ayurveda, iron formulations are prepared using phytomolecules that chelate iron and/or reduce OS. These phytomolecules are metabolized by the gut microbiota, which plays an important role in oxidative stress, release of inflammatory cytokines and GI side effects. The antioxidant, anti-inflammatory and antimicrobial actions of bio-active phytomolecules of Ayurvedic plants highlight their potential for reducing possible oxidant damage and side effects associated with iron supplementation. The present communication summarises the role of reactive oxygen species, potential of oxidant damage in causing side effects and microbial dysbiosis due to iron. Management of ‗Pandu' an anaemia -like condition described in Ayurveda and use of selected medicinal phytoactives are reviewed.

show abstract

A review on role of psychological factors in the etiopathogenesis of Pandu Roga with reference to iron deficiency anemia

Cited by 5 publications

References 12 publications

Urea‐activated 4,4'‐oxibis‐(benzenesulfonyl hydrazide) as foaming agent for low‐density unsaturated polyester resin manufacturing

Urea‐activated 4,4'‐oxibis‐(benzenesulfonyl hydrazide) as foaming agent for low‐density unsaturated polyester resin manufacturing

An Evaluation of the Efficacy, Safety, and Tolerability of Abhraloha Compared With Oral Ferrous Ascorbate on Iron Deficiency Anemia in Women: A Randomized Controlled, Parallel-Group, Assessor-Blind Clinical Trial

Untitled

Contact Info

Product

Resources

About