A Review on Recent Trends in Green Synthesis of Gold Nanoparticles for Tuberculosis

Gupta, Arti; Pandey, Sonia; Yadav, Jitendra Singh

doi:10.34172/apb.2021.002

Cited by 22 publications

(18 citation statements)

References 239 publications

(113 reference statements)

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“…Metal nanoparticles (MNPs) have emerged as promising antimicrobial vectors against ESKAPE pathogens in the last decades due to their potent therapeutic potential, readily adjustable shape and size, manageable drug delivery and release, and less probability of microbial resistance ( Gupta et al, 2021 ). The studies about MNPs with conjugated AMPs are versatile and can be categorized into gold nanoparticles ( Zheng et al, 2019 ), silver nanoparticles ( Gao et al, 2020 ), alumina nanoparticles ( Torres et al, 2019 ), ruthenium nanoparticles ( Huang et al, 2017 ), copper nanoparticles ( Ishida et al, 2020 ), hybrid nanoparticles, etc., depending on the types and state of metal nanoparticles ( Yang et al, 2020 ).…”

Section: Inorganic Materials Nanosystems Containing Antimicrobial Peptidesmentioning

confidence: 99%

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Yang

et al. 2021

Front. Microbiol.

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The security issue of human health is faced with dispiriting threats from multidrug-resistant bacteria infections induced by the abuse and misuse of antibiotics. Over decades, the antimicrobial peptides (AMPs) hold great promise as a viable alternative to treatment with antibiotics due to their peculiar antimicrobial mechanisms of action, broad-spectrum antimicrobial activity, lower drug residue, and ease of synthesis and modification. However, they universally express a series of disadvantages that hinder their potential application in the biomedical field (e.g., low bioavailability, poor protease resistance, and high cytotoxicity) and extremely waste the abundant resources of AMP database discovered over the decades. For all these reasons, the nanostructured antimicrobial peptides (Ns-AMPs), based on a variety of nanosystem modification, have made up for the deficiencies and pushed the development of novel AMP-based antimicrobial therapies. In this review, we provide an overview of the advantages of Ns-AMPs in improving therapeutic efficacy and biological stability, reducing side effects, and gaining the effect of organic targeting and drug controlled release. Then the different material categories of Ns-AMPs are described, including inorganic material nanosystems containing AMPs, organic material nanosystems containing AMPs, and self-assembled AMPs. Additionally, this review focuses on the Ns-AMPs for the effect of biological activities, with emphasis on antimicrobial activity, biosecurity, and biological stability. The “state-of-the-art” antimicrobial modes of Ns-AMPs, including controlled release of AMPs under a specific environment or intrinsic antimicrobial properties of Ns-AMPs, are also explicated. Finally, the perspectives and conclusions of the current research in this field are also summarized.

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Section: Inorganic Materials Nanosystems Containing Antimicrobial Peptidesmentioning

confidence: 99%

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Yang

et al. 2021

Front. Microbiol.

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“…27 AuNPs were synthesized for the development of biosensors for the sensitive detection of Bacillus anthrax. 28 Additionally, gold nanostars were applied for cancer therapy 28,29 and biological labeling. 30 Nanobelt AuNPs were used as transducers and resonators, and can be applied as a nanoscale sensor for medical approaches.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

“…30 Nanobelt AuNPs were used as transducers and resonators, and can be applied as a nanoscale sensor for medical approaches. 28,31 Furthermore, nanoshells have potential for photonic crystals, uorescent diagnostics, improving photoluminescent labels, catalysis, avoiding photodegradation, research into bioconjugates, and chemical and colloidal studies. 32,33 Recently, AuNPs have been used extensively as antibacterial agents against a broad range of microorganisms.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Anti-bacterial activity of gold nanocomposites as a new nanomaterial weapon to combat photogenic agents: recent advances and challenges

2021

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“…In the biomedical field, recent studies (between 2020 and 2021) mostly exploit CS and plant extracts forming nanocomposites, directed at infection prevention or control, additionally acting against oxidative stress and inflammation overload, which are critical for instance in immunocompromised patients [ 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 ]. CS is a marine-derived cationic polysaccharide, approved by the FDA (Food and Drug Administration) for wound dressing applications and cartilage repairing formulations.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

et al. 2021

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Marine-derived chitosan (CS) is a cationic polysaccharide widely studied for its bioactivity, which is mostly attached to its primary amine groups. CS is able to neutralize reactive oxygen species (ROS) from the microenvironments in which it is integrated, consequently reducing cell-induced oxidative stress. It also acts as a bacterial peripheral layer hindering nutrient intake and interacting with negatively charged outer cellular components, which lead to an increase in the cell permeability or to its lysis. Its biocompatibility, biodegradability, ease of processability (particularly in mild conditions), and chemical versatility has fueled CS study as a valuable matrix component of bioactive small-scaled organic drug-delivery systems, with current research also showcasing CS’s potential within tridimensional sponges, hydrogels and sutures, blended films, nanofiber sheets and fabric coatings. On the other hand, renewable plant-derived extracts are here emphasized, given their potential as eco-friendly radical scavengers, microbicidal agents, or alternatives to antibiotics, considering that most of the latter have induced bacterial resistance because of excessive and/or inappropriate use. Loading them into small-scaled particles potentiates a strong and sustained bioactivity, and a controlled release, using lower doses of bioactive compounds. A pH-triggered release, dependent on CS’s protonation/deprotonation of its amine groups, has been the most explored stimulus for that control. However, the use of CS derivatives, crosslinking agents, and/or additional stabilization processes is enabling slower release rates, following extract diffusion from the particle matrix, which can find major applicability in fiber-based systems within ROS-enriched microenvironments and/or spiked with microbes. Research on this is still in its infancy. Yet, the few published studies have already revealed that the composition, along with an adequate drug release rate, has an important role in controlling an existing infection, forming new tissue, and successfully closing a wound. A bioactive finishing of textiles has also been promoting high particle infiltration, superior washing durability, and biological response.

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A Review on Recent Trends in Green Synthesis of Gold Nanoparticles for Tuberculosis

Cited by 22 publications

References 239 publications

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Anti-bacterial activity of gold nanocomposites as a new nanomaterial weapon to combat photogenic agents: recent advances and challenges

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

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