A Review on Re-Packaging of Bisphosphonates Using Biomaterials

Barik, Debyashreeta; Dash, Pratigyan; Uma, P.I; Kumari, Sunita; Dash, Mamoni

doi:10.1016/j.xphs.2021.08.028

Cited by 5 publications

(2 citation statements)

References 79 publications

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“…146–148 However, in clinical practice, BPs are administered orally to produce efficacy, which cannot avoid the disadvantages of their lower absorption rate and high toxicity. 149 The development of strategies combined with scaffolds to achieve a localized administration and sustained release of BPs has been considered as a potential way to address this dilemma. 150–152 This approach could limit the appropriate concentration and activity of BPs in the defect area without affecting healthy bone tissue.…”

Section: Classification Of Hydrogels For Bone Healingmentioning

confidence: 99%

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Zhang,

Qi,

Zhang

et al. 2024

Biomater. Sci.

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Section: Classification Of Hydrogels For Bone Healingmentioning

confidence: 99%

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Zhang,

Qi,

Zhang

et al. 2024

Biomater. Sci.

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“…A similar mechanism can make BPs anticancer and cytotoxic to cancer cells. [ 4 ] Furthermore, conventional chemotherapeutic drugs, like paclitaxel, cisplatin, doxorubicin, and methotrexate, are facing a lot of problems due to the emerging multidrug resistance of cancer cells. Exploring the role of BPs as potent anticancer agent seems to open up new and unique avenues.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanoformulation of Zoledronic Acid Rescues Osteoblasts from the Harmful Effect of its Native Form: An In Vitro Investigation of Cytotoxic Potential on Osteoblasts and Osteosarcoma Cells

Dash

Samal

Panda

et al. 2023

Macromolecular Bioscience

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Osteosarcoma (OS) is a malignant tumor, fatal for pediatric patients who do not respond to chemotherapy, alternative therapies and drugs can provide better outcomes. Zoledronic acid (Zol) belonging to the class of bisphosphonates (BPs) has a direct antitumor ability to prevent Ras GTPases modification and stimulate apoptosis. Despite advances in maintaining balance in skeletal events and direct anticancer properties, Zol causes cytotoxicity to normal healthy pre‐osteoblast cells, hampering mineralization and differentiation. The study reports the preparation and evaluation of a nanoformulation that can diminish the existing drawbacks of native Zol. The cytotoxic effect is evaluated on bone cancer cells and healthy bone cells with three different cell lines namely, K7M2 (mouse OS cell line), SaOS2 (human OS cell line), and MC3T3E1 (healthy cell counterpart). It is observed that Zol nanoformulation is uptaken more (95%) in K7M2 whereas in MC3T3E1, the percent population internalizing nanoparticles (NPs) is 45%. Zol has a sustained release of 15% after 96 h from the NP which leads to a rescuing effect on the normal pre‐osteoblast cells. In conclusion, it can be stated that Zol nanoformulation can be used as a good platform for a sustained release system with minimum side effects to normal bone cells.

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Bisphosphonates: Synthesis, structures, properties, medical and industrial applications

Popov¹,

Oshchepkov

Tkachenko

et al. 2022

Journal of Molecular Liquids

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A Review on Re-Packaging of Bisphosphonates Using Biomaterials

Cited by 5 publications

References 79 publications

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Polymeric Nanoformulation of Zoledronic Acid Rescues Osteoblasts from the Harmful Effect of its Native Form: An In Vitro Investigation of Cytotoxic Potential on Osteoblasts and Osteosarcoma Cells

Bisphosphonates: Synthesis, structures, properties, medical and industrial applications

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