A review on production of polyhydroxyalkanoate (PHA) biopolyesters by thermophilic microbes using waste feedstocks

Chavan, Shraddha; Yadav, Bhoomika; Tyagi, Rajeshwar Dayal; Drogui, Patrick

doi:10.1016/j.biortech.2021.125900

Cited by 67 publications

(31 citation statements)

References 83 publications

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“…In this regard, additives that have been used to improve PLA ductility are either noncompostable or deemed unsafe for food contact. ,, PLA could be processed with food-safe polyesters, ,, like polyhydroxyalkanoate to produce ductile and compostable films. However, large-scale production of polyhydroxyalkanoate limits their widespread use . Hence, compostable and inexpensive plasticizers ,− like glycerol, sorbitol, and vegetable oils have been widely used to increase PLA ductility; nevertheless, a significant drawback of this approach is that unbound plasticizers could migrate out of PLA over time, reducing its ductility. ,, Plasticizers could be retained within the PLA matrix using modified biopolymers as the dispersed phase.…”

Section: Introductionmentioning

confidence: 99%

“…However, large-scale production of polyhydroxyalkanoate limits their widespread use. 23 Hence, compostable and inexpensive plasticizers 16,24−27 vegetable oils have been widely used to increase PLA ductility; nevertheless, a significant drawback of this approach is that unbound plasticizers could migrate out of PLA over time, reducing its ductility. 16,21,24 Plasticizers could be retained within the PLA matrix using modified biopolymers as the dispersed phase.…”

Section: ■ Introductionmentioning

confidence: 99%

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Recent Progress on Starch Maleate/Polylactic Acid Blends for Compostable Food Packaging Applications

Goswami

Nair

Wang

et al. 2021

ACS Sustainable Chem. Eng.

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Starch maleate/polylactic acid blends could replace polyethylene terephthalate in food packaging films. These films, however, are not acceptable for commercial use due to their poor performance, which is caused by processing polylactic acid with starch maleates having a low degree of maleic anhydride substitutions (DSNMR < 0.1 or DStitration < 1). Conventionally produced starch maleates produced via dry grinding or as aqueous and nonaqueous dispersions acquire a low DS due to the presence of inactive hydroxyl and maleic anhydride groups in each of the reaction systems. Low-DS starch maleates could barely interact with polylactic acid and plasticizers during blend processing; consequently, the resultant films perform poorly in terms of ductility and compostability. The key findings of this perspective indicate that recyclable ionic liquids like 1-allyl-3-methylimidazolium chloride could disrupt H-bonds among hydroxyls of starch and catalyze in situ maleic anhydride ring openings to provide functional groups for the synthesis of high-DS starch maleates (DSNMR ≥ 0.1 or DStitration ≥ 1). Improved interfacial chain interactions between high-DS starch maleates/polylactic acid and plasticizers like epoxidized soybean oil could facilitate stress-transfer and enzymatic activities of the resultant film, potentially improving its ductility and compostable properties. Besides these promising findings, this perspective also emphasizes the need for further research into identifying a wide range of ionic liquids and compostable plasticizers for producing high-DS starch maleates/polylactic acid blends, assessing the effect of interfacial chain interactions on properties of the resultant film, and determining specific usage of the film based on the barrier properties measured using standardized techniques.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Recent Progress on Starch Maleate/Polylactic Acid Blends for Compostable Food Packaging Applications

Goswami

Nair

Wang

et al. 2021

ACS Sustainable Chem. Eng.

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“…The broadly understood medical industry (medicine, biomedicine, tissue engineering, pharmacology) seems to be the largest potential market for PHAs. Potential biomedical applications of PHAs are drug delivery systems, 3D implants for bone tissue regeneration, regeneration of articular cartilage, wound healing, blood vessel reconstruction, artificial blood vessels, artificial heart tissues, organ reconstruction, artificial organ constructs, implants, scaffolds for tissue engineering and many others (Kourmentza et al 2017 ; Mohanty et al 2018 ; Chavan et al 2021 ; Tan et al 2021 ; Rekhi et al 2022 ).…”

Section: Properties and Applications Of Phasmentioning

confidence: 99%

“…In the third pathway for PHA synthesis, various carbon sources can be used: sugars, oils and fatty acids (Anjum et al 2016 ). The main factors influencing the synthesis of PHAs are: the type of microorganisms, the type of carbon source(s), the total carbon load, the nutrient concentration, the C/N and C/P ratios, the pH, the mode of fermentation and the fermenter operating parameters (Chavan et al 2021 ; Rekhi et al 2022 ). The concentration of trace metals (Fe, B, Cu, Mn, Mo, Zn) and the salinity of the culture medium also affect the efficiency of PHA synthesis (Rodriguez-Perez et al 2018 ).…”

Section: Phas Synthesis/factors Influencing Phas Synthesismentioning

confidence: 99%

Reprocessing of side-streams towards obtaining valuable bacterial metabolites

Piwowarek

Lipińska

Kieliszek

2023

Appl Microbiol Biotechnol

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Every year, all over the world, the industry generates huge amounts of residues. Side-streams are most often used as feed, landfilled, incinerated, or discharged into sewage. These disposal methods are far from perfect. Taking into account the composition of the side-streams, it seems that they should be used as raw materials for further processing, in accordance with the zero-waste policy and sustainable development. The article describes the latest achievements in biotechnology in the context of bacterial reprocessing of residues with the simultaneous acquisition of their metabolites. The article focuses on four metabolites — bacterial cellulose, propionic acid, vitamin B12 and PHAs. Taking into account global trends (e.g. food, packaging, medicine), it seems that in the near future there will be a sharp increase in demand for this type of compounds. In order for their production to be profitable and commercialised, cheap methods of its obtaining must be developed. The article, in addition to obtaining these bacterial metabolites from side-streams, also discusses e.g. factors affecting their production, metabolic pathways and potential and current applications. The presented chapters provide a complete overview of the current knowledge on above metabolites, which can be helpful for the academic and scientific communities and the several industries. Key points • The industry generates millions of tons of organic side-streams each year. • Generated residues burden the natural environment. • A good and cost-effective method of side-streams management seems to be biotechnology – reprocessing with the use of bacteria. • Biotechnological disposal of side-streams gives the opportunity to obtain valuable compounds in cheaper ways: BC, PA, vitmain B12, PHAs.

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“…PHAs possess similar mechanical, thermal, and barrier properties to petroleum-based plastics such as polyethylene and polypropylene [ 2 , 3 ]. PHAs have been used in several fields including agriculture, medicine, packaging, and pharmacy [ 1 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Improvement of the Polyhydroxyalkanoates Recovery from Mixed Microbial Cultures Using Sodium Hypochlorite Pre-Treatment Coupled with Solvent Extraction

et al. 2022

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The use of mixed microbial cultures (MMC) and organic wastes and wastewaters as feed sources is considered an appealing approach to reduce the current polyhydroxyalkanoates (PHAs) production costs. However, this method entails an additional hurdle to the PHAs downstream processing (recovery and purification). In the current work, the effect of a sodium hypochlorite (NaClO) pre-treatment coupled with dimethyl carbonate (DMC) or chloroform (CF) as extraction solvents on the PHAs recovery efficiency (RE) from MMC was evaluated. MMC were harvested from a sequencing batch reactor (SBR) fed with a synthetic prefermented olive mill wastewaster. Two different carbon-sources (acetic acid and acetic/propionic acids) were employed during the batch accumulation of polyhydroxybutyrate (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from MMC. Obtained PHAs were characterized by 1H and 13C nuclear magnetic resonance, gel-permeation chromatography, differential scanning calorimetry, and thermal gravimetric analysis. The results showed that when a NaClO pre-treatment is not added, the use of DMC allows to obtain higher RE of both biopolymers (PHB and PHBV), in comparison with CF. In contrast, the use of CF as extraction solvent required a pre-treatment step to improve the PHB and PHBV recovery. In all cases, RE values were higher for PHBV than for PHB.

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A review on production of polyhydroxyalkanoate (PHA) biopolyesters by thermophilic microbes using waste feedstocks

Cited by 67 publications

References 83 publications

Recent Progress on Starch Maleate/Polylactic Acid Blends for Compostable Food Packaging Applications

Recent Progress on Starch Maleate/Polylactic Acid Blends for Compostable Food Packaging Applications

Reprocessing of side-streams towards obtaining valuable bacterial metabolites

Improvement of the Polyhydroxyalkanoates Recovery from Mixed Microbial Cultures Using Sodium Hypochlorite Pre-Treatment Coupled with Solvent Extraction

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