A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders

Thapliyal, Surabhi; Singh, Tanveer; Handu, Shailendra; Bisht, Manisha; Kumari, Puja; Arya, Priyanka; Srivastava, Pallavi; Ravi, Gandham

doi:10.1007/s11064-021-03257-6

Cited by 43 publications

(37 citation statements)

References 189 publications

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“…Recently, FA has attracted wide attention for its nutritional and pharmacological effects, such as its antidiabetic, antihypertensive, and antitumor effects [4]. FA is also believed to have a variety of antiatherosclerotic activities, including lipid-lowering, antioxidant, and anti-inflammatory activities [5]. Although FA has a variety of promising antiatherosclerotic effects, little research has been done on cellular VSMCs.…”

Section: Introductionmentioning

confidence: 99%

Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway

Zhou

et al. 2022

J. of Cardiovasc. Trans. Res.

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The benefits and risks of inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) remain a subject of debate. In this study, we investigated the effect of ferulic acid (FA) on the proliferation and migration of VSMCs induced by platelet-derived growth factor (PDGF) and the associated mechanism and used ApoE-/- mice to study whether the effect of FA on VSMC proliferation and migration is beneficial in alleviating AS plaques. It was found that FA not only reduced blood lipid levels but also promoted the production of nitric oxide (NO) by MOVAS cells through the endothelial nitric oxide synthase (eNOS) pathway, inhibited the migration and proliferation of VSMCs induced by PDGF, promoted the expression of p21 in VSMCs, and exerted a therapeutic effect against AS.

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Section: Introductionmentioning

confidence: 99%

Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway

Zhou

et al. 2022

J. of Cardiovasc. Trans. Res.

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“…Ferulic acid (FA), an antioxidant present in plant cell walls, has been suggested to have inhibitory effects on Aβ aggregation [ 47 ]. FA was shown to protect against Aβ 42 -induced oxidative stress and neurotoxicity in rat primary cortical neurons [ 48 ].…”

Section: Small Molecules With Protective Activity Against Aβo Neurotoxicitymentioning

confidence: 99%

Protection against Amyloid-β Oligomer Neurotoxicity by Small Molecules with Antioxidative Properties: Potential for the Prevention of Alzheimer’s Disease Dementia

Araki

Kametani

2022

Antioxidants

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Soluble oligomeric assemblies of amyloid β-protein (Aβ), called Aβ oligomers (AβOs), have been recognized as primary pathogenetic factors in the molecular pathology of Alzheimer’s disease (AD). AβOs exert neurotoxicity and synaptotoxicity and play a critical role in the pathological progression of AD by aggravating oxidative and synaptic disturbances and tau abnormalities. As such, they are important therapeutic targets. From a therapeutic standpoint, it is not only important to clear AβOs or prevent their formation, it is also beneficial to reduce their neurotoxicity. In this regard, recent studies have reported that small molecules, most with antioxidative properties, show promise as therapeutic agents for reducing the neurotoxicity of AβOs. In this mini-review, we briefly review the significance of AβOs and oxidative stress in AD and summarize studies on small molecules with AβO-neurotoxicity-reducing effects. We also discuss mechanisms underlying the effects of these compounds against AβO neurotoxicity as well as their potential as drug candidates for the prevention and treatment of AD.

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“…[10][11][12] Ferulic acid, a kind of natural phenolic acid, was isolated from fruits and vegetables. 13 It has been reported that ferulic acid and its derivatives have various biological activities, including antiviral, 14 antibacterial 15 and herbicidal activities. 16 In our previous work, ferulic acid composition with a quinoline or chalcone moiety showed excellent anti-TMV activity.…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, an increasing number of antiplant virus agents are being discovered and developed from natural products 10–12 . Ferulic acid, a kind of natural phenolic acid, was isolated from fruits and vegetables 13 . It has been reported that ferulic acid and its derivatives have various biological activities, including antiviral, 14 antibacterial 15 and herbicidal activities 16 .…”

Section: Introductionmentioning

confidence: 99%

Ferulic acid derivatives with piperazine moiety as potential antiviral agents

Yuan

Wang

Liú

et al. 2022

Pest Management Science

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Background Plant virus diseases are difficult to control and severely threaten the productivity of crops, which leads to huge financial losses. To discover the new antiviral drugs, 34 novel ferulic acid derivatives with piperazine moiety were synthesized, and the antiviral activities were systematically screened as well. Results Bioassay results indicated that most of the target compounds had outstanding antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) in vivo. In particular, compound E2 exhibited remarkable curative activities to TMV and CMV with EC50 values of 189.0 and 401.7 μg/mL compared to those for ningnanmycin (387.0, 519.3 μg/mL) and ribavirin (542.1, 721.5 μg/mL). And then the mechanisms of compound E2 were studied by chlorophyll content, differentially expressed proteins and genes tests. Conclusion The excellent antiviral activity of compound E2 was closely associated with the increase in host photosynthesis, which was confirmed by chlorophyll content, differentially expressed proteins and genes assays. Compound E2 can be considered as a lead structure for the discovery of new antiviral agents. © 2022 Society of Chemical Industry.

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A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders

Cited by 43 publications

References 189 publications

Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway

Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway

Protection against Amyloid-β Oligomer Neurotoxicity by Small Molecules with Antioxidative Properties: Potential for the Prevention of Alzheimer’s Disease Dementia

Ferulic acid derivatives with piperazine moiety as potential antiviral agents

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