A Review on Phytomedicine and Their Mechanism of Action on PCOS

Pachiappan, Sudhakar; Ramalingam, Kothai; Balasubramanian, A.

doi:10.31782/ijcrr.2020.122322

Cited by 10 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, other research groups (Bilal Bin-Hafeez et al and Sneha J. Anarthe et al) demonstrated a dose-dependent immunomodulatory activity of methanolic extract of fenugreek (149,150). It has also been demonstrated that phytonutrients such as ashwagandha, amla, apigenin, and cinnamon bark extract furnish promising immunomodulatory effects for the management of PCOS, the details are summarized in Table 2 (171,172). Moreover, in Kuniaki Ota et al demonstrated that vitamin D has shown an immunomodulatory effect inhibiting the proliferation of Th1 cells and limit their cytokine production, such as IFN-γ, IL-2, and TNF-α.…”

Section: Polycystic Ovarian Syndromementioning

confidence: 82%

Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management

et al. 2022

View full text Add to dashboard Cite

Conveyance of pathogens between organisms causes communicable diseases. On the other hand, a non-communicable disease (NCD) was always thought to have no causative transmissible infective agents. Today, this clear distinction is increasingly getting blurred and NCDs are found to be associated with some transmissible components. The human microbiota carries a congregation of microbes, the majority and the most widely studied being bacteria in the gut. The adult human gut harbors ginormous inhabitant microbes, and the microbiome accommodates 150-fold more genes than the host genome. Microbial communities share a mutually beneficial relationship with the host, especially with respect to host physiology including digestion, immune responses, and metabolism. This review delineates the connection between environmental factors such as infections leading to gut dysbiosis and NCDs and explores the evidence regarding possible causal link between them. We also discuss the evidence regarding the value of appropriate therapeutic immunomodulatory nutritional interventions to reduce the development of such diseases. We behold such immunomodulatory effects have the potential to influence in various NCDs and restore homeostasis. We believe that the beginning of the era of microbiota-oriented personalized treatment modalities is not far away.

show abstract

Section: Polycystic Ovarian Syndromementioning

confidence: 82%

Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Hyperandrogenism is caused by the overproduction of ovarian androgens due to insulin resistance with hyperinsulinemia in PCOS females. It is believed that IGF-1 receptors on theca and stroma cells are the mechanism through which insulin regulates ovarian androgen production [ 44 ]. The growth hormone IGF-1 promotes granulosa cell aromatase production [ 45 ] and works in concert with FSH and LH, regulating the production of aromatase in these cells [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

Rani,

Chitme,

Kukreti

et al. 2023

Nutrients

View full text Add to dashboard Cite

Background: The plant Tinospora cordifolia (TC), traditionally known as guduchi or giloy, is used for a number of health conditions as a nutritional supplement and rejuvenation medicine. Its nutritional supplementary products are traditionally recommended for a wide range of health issues, including diabetes, menstruation discomfort, fever, obesity, inflammation, and more. Unfortunately, there has not been extensive research into its effectiveness in treating or managing insulin resistance, lipid and carbohydrate metabolism, hormonal imbalance, and metabolic syndrome-associated polycystic ovary syndrome (PCOS). Methods: Consequently, the present study was designed to induce insulin resistance, dyslipidemia, hormonal abnormality, hyperglycemia, and menstrual disturbance of PCOS using dehydroepiandrosterone (DHEA) in mice and study the effect of oral TC extracts on these factors by using ancient and modern technologies. During the 21-day study, 6 mg/100 g/day of DHEA was given to female mice. Levels of glucose, insulin, lipids, and hormones were estimated. In addition to being seen with the naked eye, the morphological and microscopic changes were also observed on histology slides. Results: The study outcomes show that pretreatment with TC preparations significantly improved biochemical and histological abnormalities in female mice. Diestrus phase was only observed in DHEA-treated animals, while cornified epithelial cells were present in TC-treated mice. Pretreatment with TC satva showed significant (p < 0.001) reductions in body weight compared to placebo. Fasting blood glucose, 1-h OGTT, and 2-h OGTT levels were all significantly lower in TC satva- and oil-treated animals in comparison to the disease control group (p < 0.001). Treatment with TC extracts resulted in a normalization of estradiol, progesterone, and testosterone levels (p < 0.05). Treatment with TC extract improved lipid profiles (p < 0.001), LH/FSH ratios (p < 0.01), fasting insulin levels (p < 0.001), HOMA-IR (p < 0.001), HOMA-Beta (p < 0.001), and QUICKI (p < 0.001). Both macroscopic and microscopic alterations were seen to be restored after TC extract treatment. After being treated with TC satva, oil, and hydroalcoholic extract, the severity of PCOS decreased by 54.86%. Conclusions: These findings lead us to the conclusion that TC extracts and satva as nutritional supplements are useful for treating PCOS and associated symptoms. It is recommended that additional research be conducted to determine the molecular mechanism of action of TC nutritional supplements on PCOS-related changes in metabolic profiles. We also recommend further clinical studies to explore the clinical efficacy and effectiveness of TC nutritional supplements in treating and/or managing PCOS.

show abstract

“…Its major bioactive components include polyphenols and cinnamaldehyde ( 131 ). It has been proven that the PCOS-treating properties of Cinnamomum zeylanicum include both reproductive and metabolic benefits ( 90 ). It was observed that cinnamonaldehyde had decreased the blood glucose through upregulating the expression of the GLUT4 gene.…”

Section: Methodsmentioning

confidence: 99%

“…Recent clinical trial findings show that menstrual disruption in women with PCOS may benefit from cinnamon supplementation of 1500 mg/kg for 6 months. It is thought to be due to insulin resistance that improves and reduces menstrual irregularities ( 90 ).…”

Section: Methodsmentioning

confidence: 99%

Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs

Malik,

Saeed,

Saleem

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

The most common cause of infertility and metabolic problems among women of reproductive age is polycystic ovary syndrome (PCOS), a multifaceted disorder. It is an endocrine disorder that occurs in approximately one in seven women. Among these PCOS patients, two thirds will not ovulate on a regular basis and seek treatment for ovulation induction. The symptoms vary in their severity, namely ovulation disorders, excessive androgen levels, or polycystic ovarian morphology. All these symptoms require a therapeutic approach. Many drugs are used to eradicate PCOS symptoms, like metformin, clomiphene citrate, spironolactone, and pioglitazone. Long-term treatment is required to achieve the desired outcome, which is often accompanied by significant adverse reactions. Some herbs and phytochemicals are equally effective for treating PCOS and produce minimal side effects. Recently, herbal products are gaining popularity due to their wide biological activities, safety, availability, and efficacy. The present review covers aetiology, current treatment, pathophysiology, and detailed pre-clinical and clinical studies on plants and phytochemicals that are proven to be useful for the treatment of symptoms associated with PCOS.

show abstract

A Review on Phytomedicine and Their Mechanism of Action on PCOS

Cited by 10 publications

References 0 publications

Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management

Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management

Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs

Contact Info

Product

Resources

About