A Review on Physicochemical Properties of Polymers Used as Filaments in 3D-Printed Tablets

Doolaanea, Abd Almonem; Latif, Nur Hanis Abd; Singh, Shubham; Kumar, Mohit; Safa’at, Mohamad Faizal; Alfatama, Mulham; Edros, Raihana; Bhatia, Amit

doi:10.1208/s12249-023-02570-3

Cited by 4 publications

(4 citation statements)

References 151 publications

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“…Five pre-dried filaments with different HPC/EU ratios containing 20% ( w / w ) of theophylline with appropriate thicknesses were prepared to ensure that they could be properly loaded into the 3D printer. For successful printing, the filament should be flexible, while simultaneously being appropriately rigid and soft [ 16 , 41 ]. Brittle filaments (too rigid) are broken by the force of the 3D printer feeding gear, and too-soft filaments become wedged between the driving gears [ 40 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…These measurements help predict the 3D printability of filaments. The stiffness of the extruded filaments was calculated from the flexure load and extension values obtained from a 3-point bending test [ 16 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…There are several challenges faced during the preparation of drug-loaded filaments for HME and commercial 3D printing; for example, the original filaments, available for commercial 3D printing, are mainly composed of acrylonitrile butadiene styrene (ABS) and polylactic acid (PLA). However, recent studies are underway to determine and evaluate suitable polymers for oral solid drugs, since ABS and PLA are not appropriate pharmaceutical-grade polymers [ 15 , 16 ]. Another challenge to the preparation of filaments through HME is the filament thickness, which should be 1.75 mm to load commercial FDM 3D printers.…”

Section: Introductionmentioning

confidence: 99%

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Geometry-Driven Fabrication of Mini-Tablets via 3D Printing: Correlating Release Kinetics with Polyhedral Shapes

Kim,

Choi,

Kang

et al. 2024

Pharmaceutics

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The aim of this study was to fabricate mini-tablets of polyhedrons containing theophylline using a fused deposition modeling (FDM) 3D printer, and to evaluate the correlation between release kinetics models and their geometric shapes. The filaments containing theophylline, hydroxypropyl cellulose (HPC), and EUDRAGIT RS PO (EU) could be obtained with a consistent thickness through pre-drying before hot melt extrusion (HME). Mini-tablets of polyhedrons ranging from tetrahedron to icosahedron were 3D-printed using the same formulation of the filament, ensuring equal volumes. The release kinetics models derived from dissolution tests of the polyhedrons, along with calculations for various physical parameters (edge, SA: surface area, SA/W: surface area/weight, SA/V: surface area/volume), revealed that the correlation between the Higuchi model and the SA/V was the highest (R2 = 0.995). It was confirmed that using 3D- printing for the development of personalized or pediatric drug products allows for the adjustment of drug dosage by modifying the size or shape of the drug while maintaining or controlling the same release profile.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Geometry-Driven Fabrication of Mini-Tablets via 3D Printing: Correlating Release Kinetics with Polyhedral Shapes

Kim,

Choi,

Kang

et al. 2024

Pharmaceutics

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“…The filament is heated until it reaches its critical point, and then the item is produced by a second extruder that is coupled to the bottom plate. This produces the object in a layer-by-layer fashion through a nozzle [ 24 , 25 , 26 ]. In addition to FDM, there are some other 3D printing technologies available that have potential applications in the medicinal industry, including powder bed fusion (PBF) [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ], inkjet technology [ 12 , 34 , 35 , 36 ], and direct energy deposition (DED) [ 37 , 38 , 39 , 40 , 41 , 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering

Balasankar,

Anbazhakan,

Arul

et al. 2023

Biomimetics

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Selective laser sintering (SLS) is an additive manufacturing process that has shown promise in the production of medical devices, including hip cups, knee trays, dental crowns, and hearing aids. SLS-based 3D-printed dosage forms have the potential to revolutionise the production of personalised drugs. The ability to manipulate the porosity of printed materials is a particularly exciting aspect of SLS. Porous tablet formulations produced by SLS can disintegrate orally within seconds, which is challenging to achieve with traditional methods. SLS also enables the creation of amorphous solid dispersions in a single step, rather than the multi-step process required with conventional methods. This review provides an overview of 3D printing, describes the operating mechanism and necessary materials for SLS, and highlights recent advances in SLS for biomedical and pharmaceutical applications. Furthermore, an in-depth comparison and contrast of various 3D printing technologies for their effectiveness in tissue engineering applications is also presented in this review.

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3D printing technology in drug delivery: Polymer properties and applications

Singh,

Kumar,

Choudhary

et al. 2023

Journal of Dispersion Science and Technology

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A Review on Physicochemical Properties of Polymers Used as Filaments in 3D-Printed Tablets

Cited by 4 publications

References 151 publications

Geometry-Driven Fabrication of Mini-Tablets via 3D Printing: Correlating Release Kinetics with Polyhedral Shapes

Geometry-Driven Fabrication of Mini-Tablets via 3D Printing: Correlating Release Kinetics with Polyhedral Shapes

Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering

3D printing technology in drug delivery: Polymer properties and applications

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