A review on phospholipids and their main applications in drug delivery systems

Li, Jing; Wang, Xuling; Zhang, Ting; Wang, Chunling; Huang, Zhenjun; Luo, Xiang; Deng, Yihui

doi:10.1016/j.ajps.2014.09.004

Cited by 792 publications

(494 citation statements)

References 96 publications

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“…The type, molar percentage and packing orientation of phospholipids determine the ultimate shape and size of the liposomes (Farge and Devaux 1992;Jing Li et al 2015). The orientation of phospholipids in liposome bilayer depends upon the length of lipid molecules and the size of head groups (Laouini et al 2012;Jing Li et al 2015). The phase transition temperature (Tc) of phospholipids is also an important criterion to choose phospholipid for the preparation of liposomes (Laouini et al 2012;Bozzuto and Molinari 2015;Jing Li et al 2015).…”

Section: Phospholipidsmentioning

confidence: 99%

“…The natural phospholipids such as egg, or soyabean phospholipids contain substantial levels of polyunsaturated fatty acids making them less stable than the synthetic equivalents (Jing Li et al 2015). The molar percentage of phospholipids varies from 55 to 100% of total liposomal components (Bozzuto and Molinari 2015;Jing Li et al 2015).…”

Section: Phospholipidsmentioning

confidence: 99%

“…The orientation of phospholipids in liposome bilayer depends upon the length of lipid molecules and the size of head groups (Laouini et al 2012;Jing Li et al 2015). The phase transition temperature (Tc) of phospholipids is also an important criterion to choose phospholipid for the preparation of liposomes (Laouini et al 2012;Bozzuto and Molinari 2015;Jing Li et al 2015). The phase transition temperature is defined as the temperature at which the lipid physical state converts from an ordered gel phase to a disordered liquid crystalline phase.…”

Section: Phospholipidsmentioning

confidence: 99%

“…The head portion can be modified by attaching a functional group. The 1,2-distearoylsn-glycero-3-phosphoethanolamine (DSPE) is an example of a functional phospholipid used to conjugate other polymers like polyethylene glycol (PEG) (Laouini et al 2012;MarquesGallego and de Kroon 2014;Jing Li et al 2015) ( Figure 2B). The type, molar percentage and packing orientation of phospholipids determine the ultimate shape and size of the liposomes (Farge and Devaux 1992;Jing Li et al 2015).…”

Section: Phospholipidsmentioning

confidence: 99%

“…The 1,2-distearoylsn-glycero-3-phosphoethanolamine (DSPE) is an example of a functional phospholipid used to conjugate other polymers like polyethylene glycol (PEG) (Laouini et al 2012;MarquesGallego and de Kroon 2014;Jing Li et al 2015) ( Figure 2B). The type, molar percentage and packing orientation of phospholipids determine the ultimate shape and size of the liposomes (Farge and Devaux 1992;Jing Li et al 2015). The orientation of phospholipids in liposome bilayer depends upon the length of lipid molecules and the size of head groups (Laouini et al 2012;Jing Li et al 2015).…”

Section: Phospholipidsmentioning

confidence: 99%

See 4 more Smart Citations

Liposome and Their Applications in Cancer Therapy

Pandey

Rani

Agarwal

2016

Braz. arch. biol. technol.

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Section: Phospholipidsmentioning

confidence: 99%

Section: Phospholipidsmentioning

confidence: 99%

Section: Phospholipidsmentioning

confidence: 99%

Section: Phospholipidsmentioning

confidence: 99%

Section: Phospholipidsmentioning

confidence: 99%

See 3 more Smart Citations

Liposome and Their Applications in Cancer Therapy

Pandey

Rani

Agarwal

2016

Braz. arch. biol. technol.

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Polar Lipids: Phospholipids and Glycolipids

Ahmad¹,

Ali²,

Ahmad³

et al. 2020

Bailey's Industrial Oil and Fat Products

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Nature was remarkably inventive in creating the variety of polar lipids that form the matrix of biological membranes. Both phospholipids and glycolipids are polar lipids and are important constituents of natural membranes. Typically found on the outer surface of cellular membranes, glycolipids maintain the stability of the membrane, facilitate cellular regulation, and enable cell‐to‐cell communication. Phospholipids are the major lipid constituent in cell membrane, thus maintaining the structural integrity between the cell and its environment and providing boundaries between compartments within the cell. Phospholipids have many functions in biological systems, including as fuels, as membrane structural elements, as signaling agents, and as surfactants. As main components of the cellular membrane, phospholipids have excellent biocompatibility and amphiphilicity. These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients, and they have a very wide range of applications in drug delivery systems. In addition, phospholipids are widely used in food, feed, agriculture, cosmetics, and chemical industries. This article focuses on the basic chemistry, sources, synthesis, physical and analytical chemistry, and applications of phospholipids and glycolipids.

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Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs)

Nicklisch

Hamdoun

2020

FEBS Letters

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Small molecule transporters (SMTs) in the ABC and SLC families are important players in disposition of diverse endo-and xenobiotics. Interactions of environmental chemicals with these transporters were first postulated in the 1990s, and since validated in numerous in vitro and in vivo scenarios. Recent results on the co-crystal structure of ABCB1 with the flame-retardant BDE-100 demonstrate that a diverse range of man-made and natural toxic molecules, hereafter termed transporter-interfering chemicals (TICs), can directly bind to SMTs and interfere with their function. TIC-binding modes mimic those of substrates, inhibitors, modulators, inducers, and possibly stimulants through direct and allosteric mechanisms. Similarly, the effects could directly or indirectly agonize, antagonize or perhaps even prime the SMT system to alter transport function. Importantly, TICs are distinguished from drugs and pharmaceuticals that interact with transporters in that exposure is unintended and inherently variant. Here, we review the molecular mechanisms of environmental chemical interaction with SMTs, the methodological considerations for their evaluation, and the future directions for TIC discovery.

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A review on phospholipids and their main applications in drug delivery systems

Cited by 792 publications

References 96 publications

Liposome and Their Applications in Cancer Therapy

Liposome and Their Applications in Cancer Therapy

Polar Lipids: Phospholipids and Glycolipids

Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs)

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