A review on pharmacology and toxicology ofElephantopus scaberLinn.

Abstract

Elephantopus scaber Linn., family Asteraceae, is a small herb found in the Neotropics, Europe, Asia, Africa and Australia. The parts of this plant have been used traditionally for the treatment of number of diseases in many countries. The plant has been extensively screened for anticancer activity. Sesquiterpene lactones such as deoxyelephantopin, isodeoxyelephantopin, scabertopin and isoscabertopin. have been found to be prominent anticancer constituents. Many other biological activities such as antimicrobial, hepatoprotective, antioxidant, antidiabetic, anti-inflammatory, analgesic, antiasthamatic, antiplatelet and wound healing ability have been reported in various research articles. This review has been envisaged with an intention to provide the scientific information about the pharmacological and toxicological profile of E. scaber.

Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from Phania matricarioides (Spreng.) Griseb.

“…P. matricarioides is included in a very large and widespread family of flowering plants that grow for ornamental purposes [8], but the family also represents a certain economic importance due to the provision of products such as cooking oils, lettuce, sunflower seeds, artichokes, sweetening agents, coffee substitutes and herbal teas [9]. In addition, many species possess medicinal properties, including antioxidant [10], antiparasitic [11], anticancer [12] and hepatoprotective [13]. In particular, the antidiarrheal, analgesic, anti-inflammatory and anti-oxidant effects of extracts have been demonstrated and correlated with some active common phytochemicals such as phenolic compounds, tannins, flavonoids, lactonic compounds, triterpenes or steroids, terpenes and organic acids [6,14,15].…”

Deoxyelephantopin induces apoptosis via oxidative stress and enhances gemcitabine sensitivity in vitro and in vivo through targeting the NF-κB signaling pathway in pancreatic cancer

“…Natural phytochemicals, promising antitumor agents, have attracted researchers' attention. Sesquiterpene lactones, natural bioactive compounds, have been shown to possess antitumor and anti-inflammatory potential [31,32]. Elephantopus scaber, a Chinese herbal medicine, is widely applied to treat a variety of diseases, such as diabetes, hepatitis, rheumatism, and infection [32,33].…”

<p>Huaier Restrains Cholangiocarcinoma Progression in vitro and in vivo Through Modulating lncRNA TP73-AS1 and Inducing Oxidative Stress</p>

“…Among them, more and more traditional Chinese medicine (TCM) which have anti-tumor properties have been discovered and investigated. [9][10][11][12] Huaier, the fruiting body of Trametes robiniophila Murr, is a kind of light-tawny mushroom parasitic on the boles of locust trees. 13 According to the records of TCM, Huaier is usually used as an anti-inflammatory.…”