A review on pharmacological properties of Bidens biternata: A potential nutraceutical

Zahara, Kulsoom; Bibi, Yamin; Tabassum, Shaista; Mudrikah,; Bashir, Tasneem; Haider, Shakeela; Araa, Anum; Ajmal, Maryam

doi:10.1016/s2222-1808(15)60894-5

Cited by 12 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results suggest that B. andicola possess a high quantity of flavonoids and phenolic compounds in its composition. This is clearly established when B. andicola is compared with another Bidens species like Bidens biternata, in which the flavonoid content is in the range of 0.004-0.016% at different parts of the plant [18]. Nevertheless, B. pilosa total flavonoid content in the extracts measured using a colorimetric assay developed by Zhishen et al…”

Section: Resultsmentioning

confidence: 97%

“…The pharmacological effects of quercetin, such as its antioxidant, anti-inflammatory, antiallergic, anti-aging, and anticancer activities, as well as its regulating effect on interleukin (IL)-6, IL-8, tumor necrosis factor, histamine, and tryptase release in mast cells, are well acknowledged [26]. Around the world, genus Bidens has been used in traditional medicine as anti-inflammatory, antimalarial, antiulcer, antiallergic, anticancer, antidiabetic, and antibacterial agents [18]; in this sense, it can be determined that the ethnobotanical use from which we started have been validated at the level of the isolated neutrophils anti-inflammatory model.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

ASSESMENT OF ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF FREEZE DRIED HYDROALCOHOLIC EXTRACT OF Bidens andicola ON ISOLATED NEUTROPHILS

Vinueza

Torres‐López

Acosta

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The aim of this study was to evaluate anti-inflammatory activity and cytotoxicity in vitro of hydroalcoholic extract of Bidens andicola.Methods: B. andicola hydroalcoholic extract was obtained from aerial parts of B. andicola, following a standardized methodology. Briefly, aerial parts of B. andicola were extracted with ethanol 70% v/v and defatted with n-hexane, hydroalcoholic fraction was concentrated under controlled conditions in a rotary evaporator, and finally the residue was freeze-drying to obtain the hydroalcoholic extract of B. andicola. Anti-inflammatory activity and cytotoxicity assays were carried out using in vitro isolated neutrophils model using stable water-soluble tetrazolium salts. Results and Conclusions:The in vitro anti-inflammatory assay on isolated neutrophils demonstrated that the hydroalcoholic extract showed antiinflammatory activity compared to aspirin, with inflammatory inhibition percent values of 80.138±0.729 to hydroalcoholic extract of B. andicola and 82.117±0.762 to aspirin, each tested in five replicates at the concentration of 200 ppm of hydroalcoholic extract or reference.

show abstract

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

ASSESMENT OF ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF FREEZE DRIED HYDROALCOHOLIC EXTRACT OF Bidens andicola ON ISOLATED NEUTROPHILS

Vinueza

Torres‐López

Acosta

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…En los extractos de raíz transformada se encontraron bandas que coinciden en su migración con la quercitina, flavonoide utilizado como referencia en esta prueba. Ya ha sido reportada la presencia del flavonoide quercetina y su contribución a las propiedades medicinales de la especie Bidens biternata (Zahara et al, 2015). Los flavonoides han sido asociados, entre otras cosas, con actividades antibacterial y antidiarreica (junto con los taninos), y B. odorata se emplea en México para el tratamiento de desórdenes gastrointestinales, tales como la diarrea (Zavala-Mendoza et al, 2013).…”

Section: Crecimiento En Cultivo De Las Raíces Transformadasunclassified

“…6E), en donde el reactivo de anisaldehído-H2SO4 reveló la presencia de siete bandas en raíces transformadas y nueve en raíces normales y parte aérea, esto al visualizar bajo luz visible. Estos compuestos podrían corresponder a aceites esenciales y su presencia sugiere una actividad antioxidante (Zahara et al, 2015), lo que abre la posibilidad de realizar una evaluación para su uso en enfermedades relacionadas con el género Mycobacterium (Aqil, Ahmad, & Owais, 2006). En los extractos acuosos, el reactivo de Liebermann-Burchard reveló solo una banda, misma que se presentó en los tres tipos de tejido analizados ( fig.…”

Section: Figunclassified

“…Estos compuestos poseen actividad antimicobacterial (Bisht et al, 2006). En el género Bidens ya se han identificado esteroides, además de diterpenos (Zahara et al, 2015). Por otro lado, las saponinas son fitoquímicos glucosilados a los cuales se les han encontrado propiedades como expectorantes y antiinflamatorios (monodesmósidos), y en el tratamiento de tumores (bidesmósidos).…”

Section: Figunclassified

See 1 more Smart Citation

OBTENTION OF TRANSFORMED ROOTS CULTURES OF THE MEDICINAL PLANT Bidens odorata Cav (COMPOSITAE) AND PRELIMINARY PHYTOCHEMICAL ANALYSIS

et al. 2018

View full text Add to dashboard Cite

RESUMEN: Se desarrolló un protocolo de propagación in vitro para Bidens odorataCav. mediante el cultivo de segmentos nodales en medio de Murashige y Skoog adicionado con citocininas. Los mejores resultados fueron 5.5 ± 0.4 brotes por explante con benciladenina y 4.9 ± 0.3 con N6-(2-isopentenil)-adenina. También se evaluó su susceptibilidad a la transformación genética con tres cepas de Agrobacterium rhizogenes. La mejor cepa fue la A4/pESC4, a una densidad bacteriana de 10 7 UFC mL -1 , que generó cultivos de raíces transformadas estables y de crecimiento activo, con una acumulación de biomasa de 4.8 veces el inóculo inicial a la tercera semana de cultivo. La verificación de la transformación se hizo histoquímicamente mediante la prueba de GUS, siendo positiva desde un 7 hasta un 82% de las raíces evaluadas; así como molecularmente, mediante la amplificación de los fragmentos correspondientes a los genes rolB, gus y nptII. El escrutinio fitoquímico realizado mediante cromatografía en capa fina reveló la capacidad que tienen las raíces transformadas para sintetizar compuestos de diversos tipos, sugiriendo la presencia de alcaloides, derivados de antraceno, aceites esenciales, flavonoides, saponinas, esteroides y triterpenos. Estos metabolitos secundarios están presentes en la parte aérea o en raíces de plantas de B. odorata, por lo que los resultados demostraron que las raíces transformadas pueden ser una opción viable para la obtención de los compuestos de interés farmacológico propios de esta especie.ABSTRACT: An in vitro propagation protocol for Bidens odorata Cav. was developed by culturing nodal stem segments on Murashige and Skoog medium added with cytokinins. The best results were 5.5 ± 0.4 shoots per explant with benzyladenine, and 4.9 ± 0.3 with N6-(2-isopentenyl)-adenine. Their susceptibility to genetic transformation with three strains of Agrobacterium rhizogenes was also evaluated. The best was the A4/pESC4 strain, at a bacterial density of 10 7 CFU mL -1 , which generated stable and active growth transformed roots cultures with a biomass accumulation of 4.8 times the initial inoculum at the third week of culture. The 243 verification of the transformation was made histochemically by the GUS test, being positive from 7 to 82% of the evaluated roots; As well as molecularly, by amplifying the fragments corresponding to the rolB, gus and nptII genes. Phytochemical screening performed by thin layer chromatography revealed the ability of transformed roots to synthesize compounds of various types, suggesting the presence of alkaloids, anthracene derivatives, essential oils, flavonoids, saponins, steroids and triterpenes. These are present in the aerial part or roots of B. odorata, so that these results showed that the transformed roots may be a viable option for obtaining the compounds of pharmacological interest of this species.

show abstract

Bidens biternata (Lour.) Merr. & Sherff Asteraceae

Khaniya¹,

Kunwar²,

Bussmann³

et al. 2020

Ethnobotany of the Himalayas

View full text Add to dashboard Cite

A review on pharmacological properties of Bidens biternata: A potential nutraceutical

Cited by 12 publications

References 17 publications

ASSESMENT OF ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF FREEZE DRIED HYDROALCOHOLIC EXTRACT OF Bidens andicola ON ISOLATED NEUTROPHILS

ASSESMENT OF ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF FREEZE DRIED HYDROALCOHOLIC EXTRACT OF Bidens andicola ON ISOLATED NEUTROPHILS

OBTENTION OF TRANSFORMED ROOTS CULTURES OF THE MEDICINAL PLANT Bidens odorata Cav (COMPOSITAE) AND PRELIMINARY PHYTOCHEMICAL ANALYSIS

Bidens biternata (Lour.) Merr. & Sherff Asteraceae

Contact Info

Product

Resources

About