A Review on Olefin Metathesis Reactions as a Green Method for the Synthesis of Organic Compounds

Abstract

Olefin metathesis is a metal-mediated C-C bond exchange by which the two fragments within the olefin precursor are redistributed as a result of breaking the double bond to obtain a new product. Currently, most of the synthetic organic compounds, polymers, drugs, plastics, and other synthetic materials are synthesized via the application of olefin metathesis reactions. In this review, different types of olefin metathesis reactions with their plausible mechanisms and their application in synthetic organic chemistry have been discussed.

Crystal structure of [1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]dichlorido(2-{[(2-methoxyethyl)(methyl)amino]methyl}benzylidene)ruthenium

“…Over the past decades, significant progress has been made in the conceptualization of methodology of organometallic catalytic systems for olefin metathesis (for selected reviews and books on the topic, see : Grela, 2014;Ogba et al, 2018;Mukherjee et al 2018;Tsedalu, 2021;Cope ´ret et al, 2021). This has made it possible to successfully overcome some of the limitations that initially prevented the integration of ruthenium catalysts in both laboratory practice and industry.…”

Palladium-Catalyzed Difunctionalization of Norbornenes via Arylation and Alkynylation

“…Norbornene is a three-dimensional cyclic olefin, which contains a cyclohexene ring with bridging methylene in the para -position . Due to the versatile character of bridged olefins, norbornene was usually used as a monomer for the synthesis of polynorbornene materials via ring opening metathesis polymerization. − In recent years, norbornenes had been widely applied to synthetic methodology. − One typical application is that norbornenes were employed as an additive in Catellani reactions to realize the site-selective difunctionalization of arenes. , Furthermore, norbornenes were also used as an additive in the C–H bond activation to realize the remote functionalization of arenes . In addition to being usually employed as an additive for realizing the functionalization of arenes, norbornenes have also been successfully applied as reaction substrates for achieving difunctionalization of the alkene bonds, such as iron-catalyzed addition of terminal alkynes to norbornenes, palladium-catalyzed addition of aryl anhydrides to norbornenes, palladium-catalyzed addition of thioesters to norbornenes, and nickel-catalyzed addition of amides to norbornenes (Figure ).…”

Synthesis of trans-Tetrafluoro(trifluoromethyl)-λ6-sulfanyl (CF3SF4)-Containing Olefins via Cross Metathesis

“…Olefin cross metathesis has found many applications in synthesis. − Grubbs’ transformative discoveries of novel catalysts , facilitated many new synthetic strategies. Recently, there has been interest in reactions of perfluorinated olefins or partially fluorinated olefins as these olefins have shown promise in pharmaceutical agents and agrochemicals, having been introduced to steroids, antiprogestines, fulvestrants, and O -allylcyclodextrins among other agents.…”