A review on nanopores based protein sensing in complex analyte

Das, Naren; Chakraborty, Bidesh; RoyChaudhuri, C.

doi:10.1016/j.talanta.2022.123368

Cited by 5 publications

(3 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are two categories of nanopores: biological nanopores and solid-state nanopores. Biological nanopores are transmembrane proteins with a nanosized pore (e.g., α-hemolysin, Mycobacterium smegmatis porin A) (77) synthetic membranes like silicon nitride, silicon oxide, graphene, and glass (78,79). Selectivity in nanopore sensors is achieved by accommodating biorecognition elements on the inner surface of the nanopore (80).…”

Section: Nanopore Sensorsmentioning

confidence: 99%

Label-Free Electrochemical Methods for Disease Detection

Rahn

Peramune

Zhang

et al. 2023

Annual Rev. Anal. Chem.

View full text Add to dashboard Cite

Label-free electrochemical biosensing leverages the advantages of label-free techniques, low cost, and fewer user steps, with the sensitivity and portability of electrochemical analysis. In this review, we identify four label-free electrochemical biosensing mechanisms: ( a) blocking the electrode surface, ( b) allowing greater access to the electrode surface, ( c) changing the intercalation or electrostatic affinity of a redox probe to a biorecognition unit, and ( d) modulating ion or electron transport properties due to conformational and surface charge changes. Each mechanism is described, recent advancements are summarized, and relative advantages and disadvantages of the techniques are discussed. Furthermore, two avenues for gaining further diagnostic information from label-free electrochemical biosensors, through multiplex analysis and incorporating machine learning, are examined. Expected final online publication date for the Annual Review of Analytical Chemistry, Volume 16 is June 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

show abstract

Section: Nanopore Sensorsmentioning

confidence: 99%

Label-Free Electrochemical Methods for Disease Detection

Rahn

Peramune

Zhang

et al. 2023

Annual Rev. Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…Ions in the electrolyte solution then form a conducting circuit via the nanopore, producing a steady ionic current (commonly referred to as open-hole current I 0 ) [4]. The analytes presenting a charge in the electrolyte solution arrive around the pore by diffusion and move from one end to the other under the interaction of two forces: electroosmotic and electrophoretic forces [14]. The diaphragm clamp's amplifier senses and amplifies the change in the current signal's amplitude caused by the blockage of the aperture currently at this point (Figure 1) [15].…”

Section: Nanopore Detection Principle Based On Resistive Pulse Techniquementioning

confidence: 99%

The signal-to-noise ratio improvement of solid-state nanopore sensors

Leng

Weng

et al. 2023

International Conference on Electronic Information Engineering and Computer Science (EIECS 2022)

View full text Add to dashboard Cite

Compared with biological nanopores, solid-state nanopores (SSN) have advantages in chemical, mechanical, and thermal stability, pore size tunability and integration, and detect a broader range of targets. However, the current problems of low signal-to-noise ratio (SNR), inefficient preparation, and poor reproducibility of solid-state nanopores remain unsolved, limiting their application to replace biological nanopores as the main sensor devices. In this paper, we address the low SNR problems of solid-state nanopores, introduce the recent research done by researchers to improve the SNR of solidstate nanopores, make a breakdown into the existing resistive pulse detection field, and give an outlook on various sensing detection methods based on nanopores.

show abstract

“…[1][2][3] Inspired by biological-ion nanochannels, tethering molecules or materials with selective recognition functionality inside the artificial solid-phase nanopore/nanochannel has become a powerful method for modulating the selectivity of ions and molecules inside the pore/channel. [4][5][6] The artificial solidstate nanopores include polyethylene terephthalate films, 7 anodized alumina oxide membranes, 8 carbon nanotubes, 9 and glass nanopipettes (GNs). 10 The GN has attracted increasing attention owing to the merits of strong plasticity, low cost, and high resolution of analysis and detection.…”

Section: Introductionmentioning

confidence: 99%