A review on modeling, simulation and experiment of electrokinetic micromixers

Huo, Xuyao; Chen, Xueye

doi:10.1080/01932691.2020.1773847

Cited by 6 publications

(4 citation statements)

References 90 publications

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“…These techniques make use of different forces and phenomena to control flow and promote effective interaction between fluids. Some of the prominent micromixing techniques include pressure gradients [31][32][33], capillary effects (thermocapillary and electrocapillary) [33,34], electrokinetics [35,36], magnetohydrodynamics (magnetic field, Lorentz forces) [37,38], rotations, centrifugal forces, and acoustic streaming [39,40].…”

Section: Mixing At the Microscalementioning

confidence: 99%

Microfluidic Mixing: A Physics-Oriented Review

Saravanakumar,

Cicek

2023

Micromachines

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This comprehensive review paper focuses on the intricate physics of microfluidics and their application in micromixing techniques. Various methods for enhancing mixing in microchannels are explored, with a keen emphasis on the underlying fluid dynamics principles. Geometrical micromixers employ complex channel designs to induce fluid–fluid interface distortions, yielding efficient mixing while retaining manufacturing simplicity. These methods synergize effectively with external techniques, showcasing promising potential. Electrohydrodynamics harnesses electrokinetic phenomena like electroosmosis, electrophoresis, and electrothermal effects. These methods offer dynamic control over mixing parameters via applied voltage, frequency, and electrode positioning, although power consumption and heating can be drawbacks. Acoustofluidics leverages acoustic waves to drive microstreaming, offering localized yet far-reaching effects. Magnetohydrodynamics, though limited in applicability to certain fluids, showcases potential by utilizing magnetic fields to propel mixing. Selecting an approach hinges on trade-offs among complexity, efficiency, and compatibility with fluid properties. Understanding the physics of fluid behavior and rationalizing these techniques aids in tailoring the most suitable micromixing solution. In a rapidly advancing field, this paper provides a consolidated understanding of these techniques, facilitating the informed choice of approach for specific microfluidic mixing needs.

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Section: Mixing At the Microscalementioning

confidence: 99%

Microfluidic Mixing: A Physics-Oriented Review

Saravanakumar,

Cicek

2023

Micromachines

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“…Most of the mixing applications consider one fluidic sample having a certain uncharged biological or chemical species and another fluidic sample of a reagent having a deficiency of that species. According to this, we consider the concentration of

C={C}_{\textit{in}}

for F 1 fluidic stream and

C=0

for F 2 fluidic stream with diffusivity D [3, 15, 16].…”

Section: Mathematical Model and Governing Equationsmentioning

confidence: 99%

Dielectric polarization‐mediated efficient solute mixing: Effect of the geometrical configuration of polarizing blocks

Pandey

Mondal

2023

Electrophoresis

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We propose a novel technique, consistent with the induced charge electrokinetic (ICEK) phenomenon, for the efficient mixing of solute species at a microfluidic scale. A nonuniform bipolar electric double layer develops in the presence of an external electric field over a polarizable object is better known as the ICEK phenomenon. This ICEK is one of the most favorable techniques preferred for enhanced solute mixing in on‐chip microfluidic platforms. In the purview of the ICEK phenomenon, instead of using perfectly conducting polarizable objects, for the first time in this study, we employ polarizable dielectric objects of different sizes and shapes for efficient mixing of solute species. We show that different types of vortices developed in the flow pathway adjacent to the polarizable dielectric blocks help in yielding efficient mixing in the proposed configuration. The novelty of our work is embellished in two different perspectives, that is, first, concentrating on the influences of the physical properties of the polarizable dielectric block on the underlying mixing, and, second, focusing on their sizes, shapes, and the arrangements in tuning the underlying mixing phenomena.

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“…In general, micromixers are categorized into two types of passive and active. , To mix the samples, passive micromixers use natural fluid behavior , while active micromixers resort to the disturbance caused by external forces. − Despite the active micromixers typically having faster mixing than the passive ones, their integration into the lab-on-a-chip systems is challenging and often expensive . Moreover, the external sources, if not well-controlled, may damage the biological samples .…”

Section: Introductionmentioning

confidence: 99%

A Novel Strategy for Square-Wave Micromixers: A Survey of RBC Lysis for Further Biological Analysis

Hazeri,

Abouei Mehrizi,

Mohseni

et al. 2023

Ind. Eng. Chem. Res.

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Most biorelated applications require homogeneous mixing, necessitating innovative approaches to design high-efficiency micromixers. In this study, for the first time, we have changed the straight structure of a base square-wave micromixer to include regularpolygon-designed mixing units coupled with convergent−divergent channels. The aim was to show that the designed mixing units can enhance mixing at low Reynolds (Re) numbers. Importantly, within the optimization process, the mixing volume and mixing length of the micromixers were kept intact. In this respect, the required numerical evaluations were conducted to obtain the optimized micromixers at Re = 0.1 and 2, where the mixing index for the base micromixer increased from 0.9187 to 0.9944 and from 0.1600 to 0.4043, respectively. Finally, to prove that the optimized micromixers possess a better practical performance than the base micromixer, RBC lysis, as a vital preprocessing step of many biological experiments, was compared at Re = 0.1 and 2 for the base and optimized micromixers.

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A review on modeling, simulation and experiment of electrokinetic micromixers

Cited by 6 publications

References 90 publications

Microfluidic Mixing: A Physics-Oriented Review

Microfluidic Mixing: A Physics-Oriented Review

Dielectric polarization‐mediated efficient solute mixing: Effect of the geometrical configuration of polarizing blocks

A Novel Strategy for Square-Wave Micromixers: A Survey of RBC Lysis for Further Biological Analysis

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