A review on methods for predicting miRNA–mRNA regulatory modules

Madhumita, Madhumita; Paul, Sushmita

doi:10.1515/jib-2020-0048

Cited by 11 publications

(9 citation statements)

References 72 publications

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“…However, miRNAs may not contribute to SCI recovery through a single pathway. Many studies are now highlighting the role of complex regulatory networks among various noncoding RNAs in human diseases [48][49][50]. miRNA regulation through a single pathway may only be part of a large network, which may point the way to future research on non-coding RNAs.…”

Section: Characterization Of Mirna Expression After Spinal Cord Injur...mentioning

confidence: 99%

Research Progress of MicroRNAs in Spinal Cord Injury

Deng¹,

Chen²

2023

J. Integr. Neurosci.

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Spinal cord injury is a serious and devastating condition. Recently, research into microRNAs (miRNAs) has become increasingly exhaustive and it has been determined that they are closely related to the pathophysiological processes of spinal cord injury. They participate in the regulation of the inflammatory response of spinal cord injury, the death of neuronal cells, and the repair of neural functions, which are related to the recovery of spinal cord injury. This review focuses on the relationship between miRNA and spinal cord injury, lists miRNA-324-5p, miRNA-221 and miRNA-124, which are helpful for the repair of spinal cord injury, and finally summarizes the current research progress of miRNA-based therapies, so as to provide a foundational reference for clinical and scientific researchers.

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Section: Characterization Of Mirna Expression After Spinal Cord Injur...mentioning

confidence: 99%

Research Progress of MicroRNAs in Spinal Cord Injury

Deng¹,

Chen²

2023

J. Integr. Neurosci.

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“…7 Mounting evidence has demonstrated that the interplay between miRNA and mRNA, formed a complex network of interactions in gene-targeted regulation. 8 MiR-620 regulated FOXM1 and HER2 expression by inhibiting aerobic glycolysis, thus affecting ESCC development and metastasis. 9 Previous research indicated that miR-196a-5p could possess either tumor suppressive or oncogenic properties, with aberrant expression observed in multiple cancers such as cervical cancer and endometrial cancer.…”

Section: Introductionmentioning

confidence: 99%

“…MiRNA typically binds to the 3′‐untranslated region (3′‐UTR) of its target messenger RNA (mRNA), resulting in a reduction in mRNA translation or degradation of mRNA transcripts 7 . Mounting evidence has demonstrated that the interplay between miRNA and mRNA, formed a complex network of interactions in gene‐targeted regulation 8 . MiR‐620 regulated FOXM1 and HER2 expression by inhibiting aerobic glycolysis, thus affecting ESCC development and metastasis 9 .…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐196a‐5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma

Xian,

Yang,

Liu

et al. 2024

Pathology International

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Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy affecting the digestive tract, with an increasing incidence rate worldwide. Recently, numerous studies revealed that microRNAs were associated with gene expression regulation, particularly their involvement in the regulation of tumor cells, garnering widespread attention. Here, we discovered that miR‐196a‐5p was significantly upregulated in both ESCC tissues and cells, which was correlated with an unfavorable prognosis. Series functional in vitro investigations have confirmed that silencing miR‐196a‐5p obviously restrained the ESCC cells malignant phenotypes and promoted apoptosis. Bioinformatics analysis and rescue experiments revealed that miR‐196a‐5p directly targeted ITM2B, exerting influence on the development of ESCC cells through negative regulation of ITM2B expression. Xenograft mouse models were established for conducting in vivo experiments, providing further confirmation of the regulatory mechanism and biological significance of the miR‐196a‐5p/ITM2B axis in ESCC. Our research demonstrated miR‐196a‐5p promoted ESCC malignant progression by interacting with ITM2B, thereby providing novel clues and potential targets for the new diagnosis and thereby of ESCC.

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“…MiRNAs are involved in several mechanisms of tumor development and progression, acting as both oncogenes and tumor suppressors, depending on the type of cell and tissue [ 4 , 5 ]. In addition, a given miRNA can regulate multiple targets, and a single target can be regulated by multiple miRNAs, showing the intricate and complex interaction between miRNA and mRNA pairings [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

MiRNAs Action and Impact on Mitochondria Function, Metabolic Reprogramming and Chemoresistance of Cancer Cells: A Systematic Review

Rosolen¹,

Nunes-Souza²,

Marchi³

et al. 2023

Biomedicines

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MicroRNAs (miRNAs) are involved in the regulation of mitochondrial function and homeostasis, and in the modulation of cell metabolism, by targeting known oncogenes and tumor suppressor genes of metabolic-related signaling pathways involved in the hallmarks of cancer. This systematic review focuses on articles describing the role, association, and/or involvement of miRNAs in regulating the mitochondrial function and metabolic reprogramming of cancer cells. Following the PRISMA guidelines, the articles reviewed were published from January 2010 to September 2022, with the search terms “mitochondrial microRNA” and its synonyms (mitochondrial microRNA, mitochondrial miRNA, mito microRNA, or mitomiR), “reprogramming metabolism,” and “cancer” in the title or abstract). Thirty-six original research articles were selected, revealing 51 miRNAs with altered expression in 12 cancers: bladder, breast, cervical, colon, colorectal, liver, lung, melanoma, osteosarcoma, pancreatic, prostate, and tongue. The actions of miRNAs and their corresponding target genes have been reported mainly in cell metabolic processes, mitochondrial dynamics, mitophagy, apoptosis, redox signaling, and resistance to chemotherapeutic agents. Altogether, these studies support the role of miRNAs in the metabolic reprogramming hallmark of cancer cells and highlight their potential as predictive molecular markers of treatment response and/or targets that can be used for therapeutic intervention.

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A review on methods for predicting miRNA–mRNA regulatory modules

Cited by 11 publications

References 72 publications

Research Progress of MicroRNAs in Spinal Cord Injury

Research Progress of MicroRNAs in Spinal Cord Injury

MicroRNA‐196a‐5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma

MiRNAs Action and Impact on Mitochondria Function, Metabolic Reprogramming and Chemoresistance of Cancer Cells: A Systematic Review

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