A Review on Medicinal Plants as a Source of Anti-inflammatory Agents

Shah, B. N.; Seth, A. K.; Maheshwari, K. M.

doi:10.3923/rjmp.2011.101.115

Cited by 67 publications

(65 citation statements)

References 20 publications

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“…Extensive investigations within the last two decades revealed that most chronic illnesses including cancer, neurological, autoimmune, diabetes, and cardiovascular diseases are mediated through inflammation. Thus, suppressing inflammation has the potential to delay, prevent, and treat these diseases (Shah et al, 2006). Therefore, inhibition of inflammatory biomarkers could be a target to treat inflammatory disorders.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect ofCareya arboreaon inflammatory biomarkers in carrageenan-induced inflammation

Begum

Sharma

Pillai

et al. 2014

Pharmaceutical Biology

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Context: Careya arborea Roxb. (Lecythidaceae) has multiple applications in traditional medicine; it exhibits analgesic, antibacterial, anti-inflammatory, antiulcer, and protective effects. However, the effect of C. arborea on biochemical and immmunological inflammatory mediators has not been explored. Objective: The present study investigates the anti-inflammatory potential of the methanol extract of C. arborea stem bark and further assesses its possible mechanism on the modulation of inflammatory biomarkers. Materials and methods: Anti-inflammatory activity of C. arborea methanol extract (CAME) was evaluated (100 and 200 mg/kg, p.o) using indomethacin (10 mg/kg, p.o) as the standard drug in Wistar albino rats. Inflammation was induced by injecting 0.1 ml carrageenan (1% w/v) into the left hind paw. The anti-inflammatory mechanism was studied by measuring malondialdehyde (MDA), C-reactive protein (CRP), nitric oxide (NO), myeloperoxidase (MPO), TNF-a, and IL-1b levels in both control and treated groups. A protocol has also been established to quantify quercetin and betulinic acid content in CAME using HPTLC fingerprint. Results: Careya arborea significantly (p50.001) decreased carrageenan-induced paw edema, showed a reduction of 48.87 and 65.53% at doses of 100 and 200 mg/kg, respectively. Moreover, CAME significantly decreased the MDA, CRP, NO, and MPO levels, elevated by carrageenan induced inflammation. CAME also markedly down-regulated serum TNF-a and IL-1b levels. These findings were further supported by the histological study. The content of quercetin and betulinic acid in CAME was found to be 0.177 and 3.14%, respectively. Conclusion: Several mechanisms, including the inhibition of pro-inflammatory cytokines, enzymes and mediators release, appear to account for the anti-inflammatory potential of C. arborea.

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect ofCareya arboreaon inflammatory biomarkers in carrageenan-induced inflammation

Begum

Sharma

Pillai

et al. 2014

Pharmaceutical Biology

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“…NO is a toxic free radical that can cause substantial tissue damage in high concentration. In stroke, large amount of NO is released from nerve cells and causes extensive damage to surrounding tissues including neurones and myocytes (Shah et al, 2011) The NO is biochemically generated via oxidation of the terminal guanidine nitrogen atom from L-arginine by NOS. NO is one of the cellular mediators of physiological and pathological process (Moncada et al, 1991;Nathan, 1992;Mollace et al, 2005).…”

Section: Inhibition Of Nitric Oxide Synthetase (Nos)mentioning

confidence: 99%

Anti-inflammatory medicinal plants and the molecular mechanisms underlying their activities

Nworu¹,

Akah²

2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Medicinal plant and plant products have shown tremendous potentials and are used beneficially in the treatment of inflammation and in the management of diseases with significant inflammatory components. Many medicinal plants employed as anti-inflammatory and antiphlogistic remedies lack the gastro-erosive side effects of non-steroidal anti-inflammatory drugs (NSAID) or the plethora of unwanted side effects associated with steroidal anti-inflammatory drugs. In order to harness and optimise the applications of these herbs in inflammatory diseases, there is a need to understand how these herbs produce their anti-inflammatory actions. Materials and Methods: This paper is a review of some anti-inflammatory herbs and their molecular mechanisms of action. A literature search and analysis of published manuscript was employed to x-ray research findings that show how medicinal plants produce anti-inflammatory activities. Results: Many studies have shown that anti-inflammatory activities of herbal extracts and herb-derived compounds are mainly due to their inhibition of arachidonic acid (AA) metabolism, cyclo-oxygenase (COX), lipo-oxygenase (LOX), pro-inflammatory cytokines, inducible nitric oxide, and transcription activation factor (NF-κB). Some anti-inflammatory medicinal herbs are reported to stabilize lysosomal membrane and some cause the uncoupling of oxidative phosphorylation of intracellular signalling molecules. Many have also been shown to possess strong oxygen radical scavenging activities. Conclusion: Most of the mechanisms by which anti-inflammatory medicinal plants act are related and many herbal products have been shown to act through a combination of these molecular pathways.

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“…For severe or chronic malignant pain opioids analgesics are drugs of choice [8]. However, prolonged use of these NSAIDs only provides asymptomatic relief and the greatest drawback lies in their toxicity to liver, kidney and gastrointestinal linings [9]. In this regard, herbal medicines from medicinal plants have been employed in complementary and alternative medicine (CAM) for treatment of pain as well as diseases related to these conditions [10].…”

Section: Introductionmentioning

confidence: 99%

Analgesic Activity of Dichloromethanolic Root Extract of Clutia abyssinica in Swiss Albino Mice

Sc¹,

Ro²,

Nm³

et al. 2017

Nat Prod Chem Res

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Pain as a sensory modality, represent a symptom for diagnosing various diseases and its associated conditions. Although it acts as a sensory modality in drawing attention to tissue injury, it is associated with poor quality of life and socioeconomic burden to the victim. Conventional synthetic drugs that are used to manage pain are not readily available and are associated with adverse effects. Thus, the use of herbal medicine from medicinal plants is an age old practice used by many communities to cure diseases. These medicinal plants are known to contain phytochemical compounds capable of relieving pain and healing diseases. C. abyssinica has been used traditionally by the Kallenjin community to alleviate various diseases. However, an extensive search of the literature reveals that no data has been documented about the medicinal use of the plant in suppressing pain. The present study thus, evaluated on analgesic potential of dichloromethanolic root extract of C. abyssinica in animal models. Thirty Swiss albino mice were grouped into six groups of five animal each; normal control, negative control, positive control and three experimental groups. The experimental animals were administered with the extract intraperitoneally at dose level of 50, 100 and 150 mg/ kg body weight. Acetic acid-induced pain was used to determine the analgesic activity of the extract. Diclofenac was used as a reference drug. The dichloromethanolic root extract reduced the number of abdominal writhing's between 33.95% and 49.77% while the reference drug reduced the number of abdominal writhing's by 46.51%. A number of phytochemical compounds associated with analgesic activity were observed to be present. The study therefore scientifically confirmed the traditional use of the medicinal plant in management of pain.

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A Review on Medicinal Plants as a Source of Anti-inflammatory Agents

Cited by 67 publications

References 20 publications

Inhibitory effect ofCareya arboreaon inflammatory biomarkers in carrageenan-induced inflammation

Inhibitory effect ofCareya arboreaon inflammatory biomarkers in carrageenan-induced inflammation

Anti-inflammatory medicinal plants and the molecular mechanisms underlying their activities

Analgesic Activity of Dichloromethanolic Root Extract of Clutia abyssinica in Swiss Albino Mice

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