A Review on Laser-Induced Breakdown Spectroscopy in Different Cancers Diagnosis and Classification

Abstract

Due to the new demonstrations of Laser-induced breakdown spectroscopy (LIBS) applicability in a surprisingly wide variety of applications, the use of LIBS as a medical diagnostic tool is steadily gaining momentum. Especially in different cancer diseases, LIBS has the potential to become a fast and valuable analytical tool. We addressed LIBS equipment and quantitative analytical procedures, and signal enhancement techniques for improving element detection. For detailed aspects of applications, we reviewed the recent progress of LIBS in different cancer diseases diagnoses by using different tissues and medical fluid as samples. To fulfill the high demands in the medical industry and overcome the severe tissue sample problem, it is proposed that the chemometric and signal amplification techniques for quantitative analysis should be employed, and robust and effective LIBS devices should be developed. This overview of the different cancers by LIBS is meant to summarize the research performed to date and suggest some suitable advanced chemometrics techniques and effective LIBS devices, if successfully implemented, would be significantly beneficial to the medical field in the future.

Evaluation of electrolyte element composition in human tissue by laser-induced breakdown spectroscopy (LIBS)

“…The results of the current study (Fig. 1 ) are consistent with assessments of other studies 24 , 25 , showing that the biological significance of small peaks tends to be overestimated, while that of large peaks tends to be underestimated.…”

“…The calibration curve was tested with K and Na according to internal standards. An initial approach simply using the intensities of a K and Na peak showed limited linearity, but a curved shape at higher K concentrations 24 – 27 . Figure 1 shows an overlay with low and high K concentrations and makes the effect of peak broadening visible by giving each concentration its own y-axis.…”

Laser-Induced Breakdown Spectroscopy Imaging for Material and Biomedical Applications: Recent Advances and Future Perspectives

“…Several laboratories have developed projects aimed at improving cancer diagnosis, which is the most studied human pathology with LIBS. Most of these studies are performed with LIBS in a microanalytical setting, either on fluids (blood or serum) or tissues . We believe that spatial information is an important parameter, especially for studying solid cancer diseases in which tumor heterogeneity is key.…”

Influence of distance from lens to sample surface on spectral sensitivity of femtosecond laser-induced breakdown spectroscopy with NaCl water film

“…However, this technology is mainly for solid samples and gas samples, while the analysis of liquid samples is still rarely reported. In recent years, the LIBS technology is extensively used to the rapid chemical element analysis of liquids, which has many potential application prospects, including water quality monitoring [9,10], environmental monitoring [11,12], food industry quality monitoring [13][14][15], medical monitoring [16][17][18], etc. But, the use of LBS technology to detect liquid samples faces a series of problems, for example, dissolved gas, particulate material and bubbles generated by previous laser pulse can cause the laser beam to fail to be focused; the liquid evaporation causes the loss of laser energy, which reduces the availability of plasma excitation energy; high local density in the liquid leads to rapid quenching, which prohibits time-selective detection, etc.…”