A Review on Iron Oxide Nanoparticles and Their Biomedical Applications

Sangaiya, P.; Jayaprakash, R.

doi:10.1007/s10948-018-4841-2

Cited by 172 publications

(86 citation statements)

References 61 publications

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“…Although different iron oxides and also Fe 3 O 4 have been previously applied for diagnosis and in tumor therapy (Sangaiya and Jayaprakash, 2018), the biocompatibility of functionalized Fe 3 O 4 MNPs is competitive to Fe 3 O 4 nanoparticles. The enhanced cytotoxicity for HeLa cells has been previously reported for L-cysteine-conjugated ruthenium oxy-hydroxide (RuO x (OH) y ) in comparison to RuO x (OH) y (Ganguly et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

“…The iron oxide nanoparticles, i.e., ferrimagnetic maghemite (γ-Fe 2 O 3 ) with Fe 3+ vacancies and ferrimagnetic magnetite (Fe 3 O 4 ≡ FeO•Fe 2 O 3 ) with Fe 2+ and Fe 3+ vacancies, have already been applied in the field of medicine due to their biocompatibility, biodegradability, and possibility to tailor magnetic behavior (Sangaiya and Jayaprakash, 2018), where the change of nanoparticle size, morphology, agglomeration, magnetic, and electronic properties influences the biological effect (Liu et al, 2016). Although magnetic targeting iron nanoparticles serve as platforms for attaching drugs like, e.g., doxorubicin (DOX), they were also applied in a tumor therapy, which resulted in a hyperthermia and oxidative stress leading to tumor cell damage (Rangam et al, 2017; Petran et al, 2018; Sangaiya and Jayaprakash, 2018). Enhancement of antitumor effect was obtained by functionalization of nanoparticles by a conventional DOX drug (Liu et al, 2016; Rangam et al, 2017) and/or doping with rare metals (Petran et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Surface Study of Fe3O4 Nanoparticles Functionalized With Biocompatible Adsorbed Molecules

et al. 2019

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Surfaces of iron oxide of ferrimagnetic magnetite (Fe3O4) nanoparticles (MNPs) prepared by Massart's method and their functionalized form (f-MNPs) with succinic acid, L-arginine, oxalic acid, citric acid, and glutamic acid were studied by dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR-S), UV-vis, thermogravimetric analysis (TGA)/differential scanning calorimetry (DSC), X-ray photoelectron spectroscopy (XPS), and reflection electron energy loss spectroscopy (REELS). The XPS analysis of elements and their chemical states at the surface of MNPs and f-MNPs revealed differences in chemical bonding of atoms, content of carbon–oxygen groups, iron oxide forms, iron oxide magnetic properties, adsorbed molecules, surface coverage, and overlayer thickness, whereas the Auger parameters (derived from XPS and Auger spectra) and elastic and inelastic scattering probabilities of electrons on atoms and valence band electrons (derived from REELS spectra) indicated modification of surface charge redistribution, electronic, and optical properties. These modified properties of f-MNPs influenced their biological properties. The surfaces biocompatible for L929 cells showed various cytotoxicity for HeLa cells (10.8–5.3% of cell death), the highest for MNPs functionalized with oxalic acid. The samples exhibiting the largest efficiency possessed smaller surface coverage and thickness of adsorbed molecules layers, the highest content of oxygen and carbon–oxygen functionalizing groups, the highest ratio of lattice O2− and OH− to C sp2 hybridizations on MNP surface, the highest ratio of adsorbed O− and OH− to C sp2 hybridizations on adsorbed molecule layers, the closest electronic and optical properties to Fe3O4, and the lowest degree of admolecule polymerization. This high cytotoxicity was attributed to interaction of cells with a surface, where increased content of oxygen groups, adsorbed O−, and OH− may play the role of additional adsorption and catalytic sites and a large content of adsorbed molecule layers of carboxylic groups facilitating Fenton reaction kinetics leading to cell damage.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface Study of Fe3O4 Nanoparticles Functionalized With Biocompatible Adsorbed Molecules

et al. 2019

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“…Maghemite (gamma‐phase iron oxide, γ‐Fe 2 O 3 ), especially in a nanoparticle form, has attracted much attention as a soft ferrimagnetic (or superparamagnetic) material with large coercivity (~5‐80 mT) for magnetic recording device, catalysts, magnetic resonance imaging, cancer treatment, and other electronic, biomedical, and environmental applications . These maghemite nanoparticles are synthesized by physical (ball milling and oxidization, deposition, spraying, etc.)…”

Section: Introductionmentioning

confidence: 99%

Cold sintering to form bulk maghemite for characterization beyond magnetic properties

Spencer

Lee

Alsaati

et al. 2019

Int J Ceramic Engine & Sci

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Maghemite nanoparticles have been sought after for electronic, biomedical, and environment applications, for their soft ferrimagnetic properties and large coercivity. While their magnetic properties are well characterized, their nonmagnetic properties are currently not available because maghemite is prepared as nanoparticles and their bulk forms often have contaminants. In this work, thermodynamically unstable maghemite nanoparticles are cold sintered (130‐250°C) to form bulk samples with submicron‐size grains. Electrical and thermal conductivities of maghemite were evaluated for the first time: 3.5 × 10−7 S/m and 0.86‐1.30 W/(mK). The relative densities of these cold‐sintered samples are low (55.9%‐64.2%) but comparable with or slightly lower than those previously achieved with higher sintering temperature (~55% at 500°C and ~76% at 1250°C). Such porous maghemite samples with large surface areas can potentially be used as an anode of lithium‐ion batteries, while further densification will be pursued in the future by sintering process modification.

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“…Among them, magnetic nanoparticles, the first generation of nanomaterials approved for clinical use, are particularly used owing to their superparamagnetic properties, which have increased the possibilities for developing novel and efficient biomedical applications [ 52 , 53 , 54 ], such as targeted drug and gene delivery, magnetic resonance imaging, biosensors, cancer detection and treatment, diagnosis and magnetic field-assisted radiotherapy, and tissue engineering [ 55 ]. The common types of iron oxide nanoparticles, which belong to the ferrimagnetic class of magnetic nanomaterials, are magnetite (Fe 3 O 4 ), maghemite (γ-Fe 2 O 3 ), hematite (α-Fe 2 O 3 ), and mixed ferrites (MFe 2 O 4 , where M = Co, Mn, Ni or Zn) [ 52 , 53 , 56 , 57 ].…”

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Mihai

Chircov

Grumezescu

et al. 2020

IJMS

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Essential oils (EOs) have attracted considerable interest in the past few years, with increasing evidence of their antibacterial, antiviral, antifungal, and insecticidal effects. However, as they are highly volatile, the administration of EOs to achieve the desired effects is challenging. Therefore, nanotechnology-based strategies for developing nanoscaled carriers for their efficient delivery might offer potential solutions. Owing to their biocompatibility, biodegradability, low toxicity, ability to target a tissue specifically, and primary structures that allow for the attachment of various therapeutics, magnetite nanoparticles (MNPs) are an example of such nanocarriers that could be used for the efficient delivery of EOs for antimicrobial therapies. The aim of this paper is to provide an overview of the use of EOs as antibacterial agents when coupled with magnetite nanoparticles (NPs), emphasizing the synthesis, properties and functionalization of such NPs to enhance their efficiency. In this manner, systems comprising EOs and MNPs could offer potential solutions that could overcome the challenges associated with biofilm formation on prosthetic devices and antibiotic-resistant bacteria by ensuring a controlled and sustained release of the antibacterial agents.

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A Review on Iron Oxide Nanoparticles and Their Biomedical Applications

Cited by 172 publications

References 61 publications

Surface Study of Fe3O4 Nanoparticles Functionalized With Biocompatible Adsorbed Molecules

Surface Study of Fe3O4 Nanoparticles Functionalized With Biocompatible Adsorbed Molecules

Cold sintering to form bulk maghemite for characterization beyond magnetic properties

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

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