A Review on Ionic Substitutions in Hydroxyapatite Thin Films: Towards Complete Biomimetism

Graziani, Gabriela; Boi, Marco; Bianchi, Michele

doi:10.3390/coatings8080269

Cited by 100 publications

(93 citation statements)

References 82 publications

(210 reference statements)

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“…Synthetic hydroxyapatite (HA) represents a well-known biocompatible material used as implantable ceramic due to its great chemical and structural resemblance to the inorganic part of human hard tissues [15,16]. Reports from dedicated literature have demonstrated that biological-derived HA (BHA) has some important advantages over synthetic HA.…”

Section: Introductionmentioning

confidence: 99%

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

et al. 2019

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Simple and lithium-doped biological-origin hydroxyapatite layers were synthesized by Pulsed Laser Deposition technique on medical grade Ti substrates. Cytotoxic effects of lithium addition and the biocompatibility of obtained coatings were assessed using three cell lines of human origin (new initiated dermal fibroblasts, immortalized keratinocytes HaCaT, and MG-63 osteosarcoma). Antimicrobial properties of obtained coatings were assessed on two strains (i.e., Staphylococcus aureus and Candida albicans), belonging to species representative for the etiology of medical devices biofilm-associated infections. Our findings suggest that synthesized lithium-doped coatings exhibited low cytotoxicity on human osteosarcoma and skin cells and therefore, an excellent biocompatibility, correlated with a long-lasting anti-staphylococcal and -fungal biofilm activity. Along with low fabrication costs generated by sustainable resources, these biological-derived materials demonstrate their promising potential for future prospective solutions—viable alternatives to commercially available biomimetic HA implants—for the fabrication of a new generation of implant coatings.

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Section: Introductionmentioning

confidence: 99%

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

et al. 2019

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“…To the difference of wet synthesis methods, plasma-assisted techniques offer important advantages, such as: (i) a much faster process for surface deposition, (ii) industrial scaling, (iii) a stoichiometric transfer of the target composition in the synthesized structures, (iv) a better uniformity in terms of morphology and composition, (v) a lower porosity, and (vi) a decreased tendency of the deposited structures to crack or delaminate [100,101]. In the biomedical domain, for the fabrication of CaP coatings for bone implant applications, the most applied plasma-assisted techniques are radio-frequency magnetron sputtering and PLD [102].…”

Section: Methods Overviewmentioning

confidence: 99%

Current Status on Pulsed Laser Deposition of Coatings from Animal-Origin Calcium Phosphate Sources

Duta

Popescu

2019

Coatings

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The aim of this paper is to present the current status on animal-origin hydroxyapatite (HA) coatings synthesized by Pulsed Laser Deposition (PLD) technique for medical implant applications. PLD as a thin film synthesis method, although limited in terms of surface covered area, still gathers interest among researchers due to its advantages such as stoichiometric transfer, thickness control, film adherence, and relatively simple experimental set-up. While animal-origin HA synthesized by bacteria or extracted from animal bones, eggshells, and clams was tested in the form of thin films or scaffolds as a bioactive agent before, the reported results on PLD coatings from HA materials extracted from natural sources were not gathered and compared until the present study. Since natural apatite contains trace elements and new functional groups, such as CO32− and HPO42− in its complex molecules, physical-chemical results on the transfer of animal-origin HA by PLD are extremely interesting due to the stoichiometric transfer possibilities of this technique. The points of interest of this paper are the origin of HA from various sustainable resources, the extraction methods employed, the supplemental functional groups, and ions present in animal-origin HA targets and coatings as compared to synthetic HA, the coatings’ morphology function of the type of HA, and the structure and crystalline status after deposition (where properties were superior to synthetic HA), and the influence of various dopants on these properties. The most interesting studies published in the last decade in scientific literature were compared and morphological, elemental, structural, and mechanical data were compiled and interpreted. The biological response of different types of animal-origin apatites on a variety of cell types was qualitatively assessed by comparing MTS assay data of various studies, where the testing conditions were possible. Antibacterial and antifungal activity of some doped animal-origin HA coatings was also discussed.

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“…This should be remarked on, as the improvement of PEEK surface roughness and wettability is envisioned to promote adhesion, spreading, proliferation, and differentiation of bone cells [68]. In the field of bioactive coatings, biomimetic coatings resembling the composition of natural bone apatite, which is indeed a calcium-deficient, highly-substituted, and poorly crystalline hydroxyapatite [69], are strongly desired, as they are expected to better promote differentiation implant osseointegration compared to highly-crystalline stoichiometric HA or other CaP phases [70][71][72]. Aiming to fabricate highly biomimetic coatings, bone apatite-like (BAL) thin films were deposited on titanium substrate for the first time by direct ablation of a biogenic source; i.e., a deproteinized bovine bone shaft, by making use of IJD technology [73,74].…”

Section: Bioactive Coatings and Thin Films By Pedmentioning

confidence: 99%

The Pulsed Electron Deposition Technique for Biomedical Applications: A Review

et al. 2019

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The "pulsed electron deposition" (PED) technique, in which a solid target material is ablated by a fast, high-energy electron beam, was initially developed two decades ago for the deposition of thin films of metal oxides for photovoltaics, spintronics, memories, and superconductivity, and dielectric polymer layers. Recently, PED has been proposed for use in the biomedical field for the fabrication of hard and soft coatings. The first biomedical application was the deposition of low wear zirconium oxide coatings on the bearing components in total joint replacement. Since then, several works have reported the manufacturing and characterization of coatings of hydroxyapatite, calcium phosphate substituted (CaP), biogenic CaP, bioglass, and antibacterial coatings on both hard (metallic or ceramic) and soft (plastic or elastomeric) substrates. Due to the growing interest in PED, the current maturity of the technology and the low cost compared to other commonly used physical vapor deposition techniques, the purpose of this work was to review the principles of operation, the main applications, and the future perspectives of PED technology in medicine.

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A Review on Ionic Substitutions in Hydroxyapatite Thin Films: Towards Complete Biomimetism

Cited by 100 publications

References 82 publications

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

Current Status on Pulsed Laser Deposition of Coatings from Animal-Origin Calcium Phosphate Sources

The Pulsed Electron Deposition Technique for Biomedical Applications: A Review

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