A Review on <i>Bryophyllum pinnatum</i> (Lam.) Oken

Mule, Priyanka; Upadhye, Mohini; Taru, Poonam; Dhole, Shashikant

doi:10.5958/0975-4385.2020.00019.9

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bryophyllum pinnatum (B. pinnatum), also known as the air plant or leaf of life, is a succulent plant with medicinal potentials [27]. It contains various phytochemicals such as flavonoids, alkaloids, tannins, saponins, sterols, and glycosides [28,29,30].…”

Section: Bryophyllum Pinnatummentioning

confidence: 99%

Unlocking Neurodegeneration: Scaffold-Derived Blockers of MAO-B and AChE inspired by Bryophyllum pinnatum: A Structural Exploration

Olugbogi,

Omirin,

Omoseeye

et al. 2024

Preprint

View full text Add to dashboard Cite

Alzheimer's disease (AD)and Parkinson's disease (PD) are progressive neurodegenerative disorders with overlapping symptoms. Reduced acetylcholine levels in AD are addressed using Acetylcholinesterase (AChE) inhibitors. Monoamine oxidase B (MAO-B) inhibitors prevent dopamine breakdown in PD. Bryophyllum pinnatum, a medicinal plant, that has been used as traditional treatments for various disorders because of its phytochemicals. This study explores its ligands as potential medications for AD and PD by inhibition of AChE and MAO-B. Computer-aided drug design was conducted using Schrödinger Suite software and Maestro 12.8. Ligands from B. pinnatum and standard drugs were docked to the active sites of MAO-B and AChE. ADMET screening and MM/GBSA analysis were performed. Pharmacophore modeling was used to identify compounds matching the reference ligands. After application of all screenings, 4 and 6 hit compounds were found for MAO B & AChE respectively based on good docking score and MM/GBSA as well as good ADMET properties. Pinoresinol was found to be the most potent of the hit compounds. These compounds could be used as neuroprotective agent in near future. Hence, this study provides evidence for consideration of valuable ligands in Bryophyllum pinnatum as potential AChE and MAO-B inhibitors and further in vivo and in vitroinvestigation might prove their therapeutic potential.

show abstract

Section: Bryophyllum Pinnatummentioning

confidence: 99%

Unlocking Neurodegeneration: Scaffold-Derived Blockers of MAO-B and AChE inspired by Bryophyllum pinnatum: A Structural Exploration

Olugbogi,

Omirin,

Omoseeye

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…B. pinnatum grows widely and is used in folkloric medicine in Africa, America, India, China and Australia (10). It is used extensively for the treatment of ailments such as conjuctivis, edema, piles, cuts, eczema, constipation, epilepsy, cholera, asthma, chest colds, menstrual disorders, chicken pox, fever (11) and for alleviating abdominal discomforts (12). Bryophyllum pinnatum is enriched with a diverse variety of the pharmacological active chemicals (13) and therefore it necessitates carrying out further scientific research in order to confirm the justification behind its use in folk therapeutics (14).…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostic study and sedative activity of Bryophyllum pinnatum stem methanol extract and fractions

Okoye,

Anowi,

Ejiofor

et al. 2023

sciphy

View full text Add to dashboard Cite

Insomnia is known as sleep insufficiency and is considered a capital public health concern. Bryophyllum pinnatum which belongs to the family Grassulaceae is used in folkloric medicine to treat various kind of ailment. The aim of the study was to undertake a pharmacognostic study of the stem and determine the sedative/hypnotic ability of the methanol extract and fraction of the stem. The physicochemical analysis indicated moisture content (12.68%), total ash (3.75%), acid insoluble ash (2.60%), water soluble ash (2.00%), water soluble extractive (6.02%) and alcohol soluble extractive (10.80%). The organoleptic evaluation of the powdered leaves revealed an odorless, green plant with bitter taste. The microscopic analysis of the leaf revealed palisade cell, spongy cell, stoma, collenchyma, xylem tissue, phloem tissue. The transverse section of the stem revealed epidermis, endodermis, xylem and cortex. The acute toxicity result revealed that Picralima nitida had no adverse effect in Wistar mice. The result showed that ethyl acetate fraction had sedative/hypnotic ability, affected the level of liver enzymes (ALT, AST, ALP), improved kidney function, and insignificantly increased body weight of mice. This study demonstrated that B. pinnatum could be an alternative medicine in pharmacological treatment of insomnia.

show abstract

Kalanchoe pinnata (Patharchatta): A Therapeutic Boon to Mankind

Wadhwa

Boora

Soniya

et al. 2023

AIA

View full text Add to dashboard Cite

Bryophyllum pinnatum, commonly known as the “patharchatta,” belongs to the family of “Crassulaceae.” Bryophyllum pinnatum is often used to treat gallbladder stones and heal wounds. It possesses a lot of pharmacological properties, such as antioxidant, anti-cancerous, antimicrobial, antiviral, etc. It is an aromatic plant having a sweet and sour smell and is used as a herb. In different plant species, essential oils present in the leaves and other parts give them their unique smell and fragrance. Many phytochemicals have been isolated from this plant, like alkaloids, triterpenes, cardenolides, flavonoids, and bufadienolides, as well as lipids, steroids, and glycosides from various extracts. Among them, only some compounds have medicinal properties. In this review, we have analyzed the ADME properties of the phytochemicals present in the plant to identify which chemical can act as a drug candidate using the SwissADME server.

show abstract

A Review on Bryophyllum pinnatum (Lam.) Oken

Cited by 4 publications

References 0 publications

Unlocking Neurodegeneration: Scaffold-Derived Blockers of MAO-B and AChE inspired by Bryophyllum pinnatum: A Structural Exploration

Unlocking Neurodegeneration: Scaffold-Derived Blockers of MAO-B and AChE inspired by Bryophyllum pinnatum: A Structural Exploration

Pharmacognostic study and sedative activity of Bryophyllum pinnatum stem methanol extract and fractions

Kalanchoe pinnata (Patharchatta): A Therapeutic Boon to Mankind

Contact Info

Product

Resources

About